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Gene: TBX3 |
Gene summary for TBX3 |
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Gene information | Species | Human | Gene symbol | TBX3 | Gene ID | 6926 |
Gene name | T-box transcription factor 3 | |
Gene Alias | TBX3-ISO | |
Cytomap | 12q24.21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024RBQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6926 | TBX3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.20e-04 | 4.17e-01 | -0.059 |
6926 | TBX3 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.09e-08 | 3.59e-01 | 0.096 |
6926 | TBX3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.06e-09 | 3.39e-01 | 0.0674 |
6926 | TBX3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.04e-29 | 6.06e-01 | 0.294 |
6926 | TBX3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.00e-05 | 2.27e-01 | 0.3859 |
6926 | TBX3 | A002-C-010 | Human | Colorectum | FAP | 3.54e-06 | 4.34e-01 | 0.242 |
6926 | TBX3 | A001-C-207 | Human | Colorectum | FAP | 9.07e-08 | 5.93e-01 | 0.1278 |
6926 | TBX3 | A015-C-203 | Human | Colorectum | FAP | 3.08e-15 | 6.13e-01 | -0.1294 |
6926 | TBX3 | A002-C-201 | Human | Colorectum | FAP | 9.26e-06 | 4.85e-01 | 0.0324 |
6926 | TBX3 | A002-C-203 | Human | Colorectum | FAP | 1.43e-09 | 4.66e-01 | 0.2786 |
6926 | TBX3 | A001-C-108 | Human | Colorectum | FAP | 8.11e-08 | 4.46e-01 | -0.0272 |
6926 | TBX3 | A002-C-021 | Human | Colorectum | FAP | 2.61e-25 | 6.14e-01 | 0.1171 |
6926 | TBX3 | A001-C-104 | Human | Colorectum | FAP | 9.17e-17 | 5.19e-01 | 0.0184 |
6926 | TBX3 | A015-C-106 | Human | Colorectum | FAP | 1.81e-11 | 5.69e-01 | -0.0511 |
6926 | TBX3 | A015-C-104 | Human | Colorectum | FAP | 7.09e-10 | 4.87e-01 | -0.1899 |
6926 | TBX3 | A001-C-014 | Human | Colorectum | FAP | 2.29e-08 | 4.95e-01 | 0.0135 |
6926 | TBX3 | A014-C-008 | Human | Colorectum | FAP | 1.16e-04 | 5.31e-01 | -0.191 |
6926 | TBX3 | A018-E-020 | Human | Colorectum | FAP | 4.02e-02 | 3.79e-01 | -0.2034 |
6926 | TBX3 | F072B | Human | Colorectum | FAP | 1.06e-02 | 3.11e-01 | 0.257 |
6926 | TBX3 | AEH-subject1 | Human | Endometrium | AEH | 1.22e-10 | -4.04e-01 | -0.3059 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0061180 | Colorectum | AD | mammary gland epithelium development | 28/3918 | 67/18723 | 8.74e-05 | 1.35e-03 | 28 |
GO:0022612 | Colorectum | AD | gland morphogenesis | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0060443 | Colorectum | AD | mammary gland morphogenesis | 18/3918 | 43/18723 | 1.51e-03 | 1.27e-02 | 18 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:0048736 | Colorectum | AD | appendage development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0060173 | Colorectum | AD | limb development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0001763 | Colorectum | AD | morphogenesis of a branching structure | 56/3918 | 196/18723 | 6.60e-03 | 4.09e-02 | 56 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00611802 | Colorectum | MSS | mammary gland epithelium development | 28/3467 | 67/18723 | 8.47e-06 | 2.11e-04 | 28 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBX3 | insertion | Frame_Shift_Ins | novel | c.438dupA | p.Ala147SerfsTer13 | p.A147Sfs*13 | O15119 | protein_coding | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | ||
TBX3 | deletion | Frame_Shift_Del | c.246delG | p.Gln84ArgfsTer4 | p.Q84Rfs*4 | O15119 | protein_coding | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
TBX3 | deletion | Frame_Shift_Del | novel | c.2141_2142delNN | p.Lys714ArgfsTer15 | p.K714Rfs*15 | O15119 | protein_coding | TCGA-DM-A28G-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TBX3 | insertion | Frame_Shift_Ins | novel | c.438_439insA | p.Ala147SerfsTer13 | p.A147Sfs*13 | O15119 | protein_coding | TCGA-DM-A28G-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TBX3 | insertion | Frame_Shift_Ins | novel | c.583_584insG | p.Glu195GlyfsTer32 | p.E195Gfs*32 | O15119 | protein_coding | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TBX3 | deletion | Frame_Shift_Del | c.643_646delGACA | p.Asp215AsnfsTer27 | p.D215Nfs*27 | O15119 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TBX3 | insertion | Frame_Shift_Ins | novel | c.1325_1326insAGCCCCGCCACCAT | p.Ser443AlafsTer194 | p.S443Afs*194 | O15119 | protein_coding | TCGA-G4-6306-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TBX3 | SNV | Missense_Mutation | novel | c.541N>T | p.Pro181Ser | p.P181S | O15119 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBX3 | SNV | Missense_Mutation | novel | c.541C>T | p.Pro181Ser | p.P181S | O15119 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBX3 | SNV | Missense_Mutation | novel | c.1958G>T | p.Ser653Ile | p.S653I | O15119 | protein_coding | deleterious(0.01) | benign(0.229) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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