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Gene: TBC1D9 |
Gene summary for TBC1D9 |
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Gene information | Species | Human | Gene symbol | TBC1D9 | Gene ID | 23158 |
Gene name | TBC1 domain family member 9 | |
Gene Alias | GRAMD9 | |
Cytomap | 4q31.21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6ZT07 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23158 | TBC1D9 | GSM4909282 | Human | Breast | IDC | 2.82e-02 | -2.13e-01 | -0.0288 |
23158 | TBC1D9 | GSM4909285 | Human | Breast | IDC | 2.91e-07 | -2.43e-01 | 0.21 |
23158 | TBC1D9 | GSM4909291 | Human | Breast | IDC | 6.41e-15 | 6.05e-01 | 0.1753 |
23158 | TBC1D9 | GSM4909293 | Human | Breast | IDC | 1.26e-06 | 2.41e-01 | 0.1581 |
23158 | TBC1D9 | GSM4909297 | Human | Breast | IDC | 8.69e-03 | 1.79e-01 | 0.1517 |
23158 | TBC1D9 | GSM4909298 | Human | Breast | IDC | 4.97e-26 | 5.64e-01 | 0.1551 |
23158 | TBC1D9 | GSM4909301 | Human | Breast | IDC | 1.15e-17 | 6.00e-01 | 0.1577 |
23158 | TBC1D9 | GSM4909302 | Human | Breast | IDC | 8.76e-17 | 5.82e-01 | 0.1545 |
23158 | TBC1D9 | GSM4909303 | Human | Breast | IDC | 1.90e-02 | 4.27e-01 | 0.0438 |
23158 | TBC1D9 | GSM4909304 | Human | Breast | IDC | 6.53e-15 | 4.25e-01 | 0.1636 |
23158 | TBC1D9 | GSM4909306 | Human | Breast | IDC | 1.48e-42 | 8.22e-01 | 0.1564 |
23158 | TBC1D9 | GSM4909307 | Human | Breast | IDC | 4.13e-03 | 2.71e-01 | 0.1569 |
23158 | TBC1D9 | GSM4909308 | Human | Breast | IDC | 1.48e-07 | 3.15e-01 | 0.158 |
23158 | TBC1D9 | GSM4909311 | Human | Breast | IDC | 2.18e-07 | -3.90e-02 | 0.1534 |
23158 | TBC1D9 | GSM4909313 | Human | Breast | IDC | 2.51e-02 | 2.69e-01 | 0.0391 |
23158 | TBC1D9 | GSM4909319 | Human | Breast | IDC | 9.11e-15 | 2.87e-03 | 0.1563 |
23158 | TBC1D9 | GSM4909321 | Human | Breast | IDC | 4.49e-03 | 1.71e-01 | 0.1559 |
23158 | TBC1D9 | brca1 | Human | Breast | Precancer | 2.09e-04 | -2.32e-01 | -0.0338 |
23158 | TBC1D9 | M1 | Human | Breast | IDC | 1.99e-21 | 6.94e-01 | 0.1577 |
23158 | TBC1D9 | M5 | Human | Breast | IDC | 1.87e-07 | 7.70e-01 | 0.1598 |
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Tissue | Expression Dynamics | Abbreviation |
Breast | ![]() | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ | ||
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:004308710 | Oral cavity | OSCC | regulation of GTPase activity | 165/7305 | 348/18723 | 7.94e-04 | 4.27e-03 | 165 |
GO:004308713 | Prostate | Tumor | regulation of GTPase activity | 88/3246 | 348/18723 | 1.04e-04 | 1.00e-03 | 88 |
GO:004354713 | Prostate | Tumor | positive regulation of GTPase activity | 60/3246 | 255/18723 | 6.87e-03 | 3.11e-02 | 60 |
GO:004308718 | Thyroid | PTC | regulation of GTPase activity | 148/5968 | 348/18723 | 1.63e-05 | 1.71e-04 | 148 |
GO:004354714 | Thyroid | PTC | positive regulation of GTPase activity | 103/5968 | 255/18723 | 2.38e-03 | 1.25e-02 | 103 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
GO:004354715 | Thyroid | ATC | positive regulation of GTPase activity | 106/6293 | 255/18723 | 4.58e-03 | 1.89e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D9 | SNV | Missense_Mutation | rs370619288 | c.2353N>T | p.Arg785Trp | p.R785W | Q6ZT07 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D9 | SNV | Missense_Mutation | rs376048979 | c.524N>A | p.Arg175His | p.R175H | Q6ZT07 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D9 | SNV | Missense_Mutation | novel | c.3541N>A | p.Glu1181Lys | p.E1181K | Q6ZT07 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.713) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D9 | SNV | Missense_Mutation | novel | c.2785N>A | p.Leu929Ile | p.L929I | Q6ZT07 | protein_coding | deleterious(0.02) | benign(0.078) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D9 | SNV | Missense_Mutation | c.1369N>A | p.Pro457Thr | p.P457T | Q6ZT07 | protein_coding | tolerated(0.21) | benign(0.041) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | |
TBC1D9 | SNV | Missense_Mutation | rs753790959 | c.2594N>A | p.Arg865His | p.R865H | Q6ZT07 | protein_coding | tolerated(0.05) | benign(0.348) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D9 | SNV | Missense_Mutation | novel | c.1592N>T | p.Ala531Val | p.A531V | Q6ZT07 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TBC1D9 | SNV | Missense_Mutation | c.1817N>C | p.Val606Ala | p.V606A | Q6ZT07 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
TBC1D9 | SNV | Missense_Mutation | rs748992099 | c.1124N>A | p.Arg375Gln | p.R375Q | Q6ZT07 | protein_coding | deleterious(0.03) | benign(0.135) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
TBC1D9 | SNV | Missense_Mutation | novel | c.2231A>C | p.Lys744Thr | p.K744T | Q6ZT07 | protein_coding | deleterious(0.01) | benign(0.297) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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