![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TBC1D14 |
Gene summary for TBC1D14 |
![]() |
Gene information | Species | Human | Gene symbol | TBC1D14 | Gene ID | 57533 |
Gene name | TBC1 domain family member 14 | |
Gene Alias | TBC1D14 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9P2M4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57533 | TBC1D14 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.63e-12 | -4.86e-01 | 0.0155 |
57533 | TBC1D14 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.07e-04 | -1.63e-01 | -0.0811 |
57533 | TBC1D14 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.22e-03 | -3.47e-01 | -0.1088 |
57533 | TBC1D14 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.22e-06 | -4.22e-01 | 0.096 |
57533 | TBC1D14 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.87e-08 | -4.48e-01 | 0.294 |
57533 | TBC1D14 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.01e-08 | -4.13e-01 | 0.3005 |
57533 | TBC1D14 | F007 | Human | Colorectum | FAP | 3.03e-02 | -3.09e-01 | 0.1176 |
57533 | TBC1D14 | A002-C-010 | Human | Colorectum | FAP | 4.64e-02 | -1.60e-01 | 0.242 |
57533 | TBC1D14 | A001-C-207 | Human | Colorectum | FAP | 3.70e-03 | -2.99e-01 | 0.1278 |
57533 | TBC1D14 | A015-C-203 | Human | Colorectum | FAP | 2.78e-23 | -3.21e-01 | -0.1294 |
57533 | TBC1D14 | A015-C-204 | Human | Colorectum | FAP | 3.05e-04 | -2.06e-01 | -0.0228 |
57533 | TBC1D14 | A014-C-040 | Human | Colorectum | FAP | 9.69e-05 | -5.15e-01 | -0.1184 |
57533 | TBC1D14 | A002-C-201 | Human | Colorectum | FAP | 1.13e-09 | -2.47e-01 | 0.0324 |
57533 | TBC1D14 | A001-C-119 | Human | Colorectum | FAP | 7.04e-07 | -3.27e-01 | -0.1557 |
57533 | TBC1D14 | A001-C-108 | Human | Colorectum | FAP | 8.74e-10 | -2.03e-01 | -0.0272 |
57533 | TBC1D14 | A002-C-205 | Human | Colorectum | FAP | 1.87e-19 | -3.73e-01 | -0.1236 |
57533 | TBC1D14 | A015-C-005 | Human | Colorectum | FAP | 2.94e-05 | -3.17e-01 | -0.0336 |
57533 | TBC1D14 | A015-C-006 | Human | Colorectum | FAP | 7.80e-12 | -4.25e-01 | -0.0994 |
57533 | TBC1D14 | A015-C-106 | Human | Colorectum | FAP | 1.59e-09 | -2.06e-01 | -0.0511 |
57533 | TBC1D14 | A002-C-114 | Human | Colorectum | FAP | 1.75e-15 | -3.63e-01 | -0.1561 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0042147 | Colorectum | AD | retrograde transport, endosome to Golgi | 37/3918 | 91/18723 | 1.46e-05 | 3.14e-04 | 37 |
GO:0010507 | Colorectum | AD | negative regulation of autophagy | 31/3918 | 85/18723 | 6.91e-04 | 7.05e-03 | 31 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:00313302 | Colorectum | MSS | negative regulation of cellular catabolic process | 96/3467 | 262/18723 | 2.67e-12 | 4.63e-10 | 96 |
GO:00098952 | Colorectum | MSS | negative regulation of catabolic process | 110/3467 | 320/18723 | 7.88e-12 | 1.20e-09 | 110 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00164822 | Colorectum | MSS | cytosolic transport | 59/3467 | 168/18723 | 2.29e-07 | 9.79e-06 | 59 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D14 | SNV | Missense_Mutation | novel | c.244A>T | p.Ser82Cys | p.S82C | Q9P2M4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.533) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TBC1D14 | SNV | Missense_Mutation | rs570309392 | c.256G>A | p.Val86Met | p.V86M | Q9P2M4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.379) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TBC1D14 | SNV | Missense_Mutation | c.843N>T | p.Lys281Asn | p.K281N | Q9P2M4 | protein_coding | deleterious(0.02) | benign(0.218) | TCGA-64-5779-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | |
TBC1D14 | SNV | Missense_Mutation | c.1175G>C | p.Arg392Thr | p.R392T | Q9P2M4 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-69-7980-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D14 | SNV | Missense_Mutation | c.247N>T | p.Ala83Ser | p.A83S | Q9P2M4 | protein_coding | tolerated_low_confidence(0.38) | benign(0.018) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TBC1D14 | SNV | Missense_Mutation | c.827C>T | p.Ser276Leu | p.S276L | Q9P2M4 | protein_coding | deleterious(0.02) | benign(0.06) | TCGA-86-8278-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | etoposide | SD | |
TBC1D14 | SNV | Missense_Mutation | novel | c.314N>T | p.Cys105Phe | p.C105F | Q9P2M4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.202) | TCGA-95-7562-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
TBC1D14 | SNV | Missense_Mutation | c.264G>T | p.Arg88Ser | p.R88S | Q9P2M4 | protein_coding | tolerated_low_confidence(0.05) | benign(0.115) | TCGA-J2-8192-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
TBC1D14 | SNV | Missense_Mutation | novel | c.1620G>A | p.Met540Ile | p.M540I | Q9P2M4 | protein_coding | deleterious(0.02) | benign(0.18) | TCGA-MP-A4T8-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | navelbine | SD |
TBC1D14 | SNV | Missense_Mutation | novel | c.1621G>T | p.Ala541Ser | p.A541S | Q9P2M4 | protein_coding | tolerated(0.12) | benign(0.349) | TCGA-MP-A4T8-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | navelbine | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |