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Gene: TAX1BP1 |
Gene summary for TAX1BP1 |
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Gene information | Species | Human | Gene symbol | TAX1BP1 | Gene ID | 8887 |
Gene name | Tax1 binding protein 1 | |
Gene Alias | CALCOCO3 | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86VP1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8887 | TAX1BP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.31e-07 | -3.63e-01 | 0.0155 |
8887 | TAX1BP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.37e-04 | 5.51e-01 | -0.0811 |
8887 | TAX1BP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.88e-04 | 5.52e-01 | -0.1088 |
8887 | TAX1BP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.00e-18 | 7.02e-01 | -0.1954 |
8887 | TAX1BP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-02 | 7.45e-01 | -0.2602 |
8887 | TAX1BP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.73e-06 | -3.96e-01 | 0.3005 |
8887 | TAX1BP1 | A002-C-010 | Human | Colorectum | FAP | 1.82e-04 | -9.05e-02 | 0.242 |
8887 | TAX1BP1 | A001-C-207 | Human | Colorectum | FAP | 2.26e-03 | -5.34e-02 | 0.1278 |
8887 | TAX1BP1 | A015-C-203 | Human | Colorectum | FAP | 1.51e-28 | -2.59e-01 | -0.1294 |
8887 | TAX1BP1 | A015-C-204 | Human | Colorectum | FAP | 1.34e-06 | -2.11e-01 | -0.0228 |
8887 | TAX1BP1 | A014-C-040 | Human | Colorectum | FAP | 2.99e-06 | -2.40e-01 | -0.1184 |
8887 | TAX1BP1 | A002-C-201 | Human | Colorectum | FAP | 3.41e-16 | -2.93e-01 | 0.0324 |
8887 | TAX1BP1 | A001-C-119 | Human | Colorectum | FAP | 7.75e-08 | -5.96e-02 | -0.1557 |
8887 | TAX1BP1 | A001-C-108 | Human | Colorectum | FAP | 1.23e-14 | -7.33e-03 | -0.0272 |
8887 | TAX1BP1 | A002-C-205 | Human | Colorectum | FAP | 7.85e-27 | 4.50e-02 | -0.1236 |
8887 | TAX1BP1 | A015-C-005 | Human | Colorectum | FAP | 1.87e-03 | -7.47e-02 | -0.0336 |
8887 | TAX1BP1 | A015-C-006 | Human | Colorectum | FAP | 2.85e-17 | -3.84e-01 | -0.0994 |
8887 | TAX1BP1 | A015-C-106 | Human | Colorectum | FAP | 1.27e-12 | -2.59e-01 | -0.0511 |
8887 | TAX1BP1 | A002-C-114 | Human | Colorectum | FAP | 1.07e-19 | -2.33e-01 | -0.1561 |
8887 | TAX1BP1 | A015-C-104 | Human | Colorectum | FAP | 1.76e-29 | -2.55e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051090 | Colorectum | MSS | regulation of DNA-binding transcription factor activity | 106/3467 | 440/18723 | 1.88e-03 | 1.65e-02 | 106 |
GO:00510901 | Colorectum | FAP | regulation of DNA-binding transcription factor activity | 80/2622 | 440/18723 | 7.90e-03 | 4.67e-02 | 80 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:00434332 | Esophagus | ESCC | negative regulation of DNA-binding transcription factor activity | 103/8552 | 185/18723 | 3.86e-03 | 1.57e-02 | 103 |
GO:00320882 | Esophagus | ESCC | negative regulation of NF-kappaB transcription factor activity | 54/8552 | 93/18723 | 1.08e-02 | 3.67e-02 | 54 |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
GO:00510903 | Lung | IAC | regulation of DNA-binding transcription factor activity | 76/2061 | 440/18723 | 4.44e-05 | 1.05e-03 | 76 |
GO:005109011 | Lung | AIS | regulation of DNA-binding transcription factor activity | 64/1849 | 440/18723 | 1.04e-03 | 1.36e-02 | 64 |
GO:00510907 | Oral cavity | OSCC | regulation of DNA-binding transcription factor activity | 221/7305 | 440/18723 | 9.06e-07 | 1.23e-05 | 221 |
GO:0032088 | Oral cavity | OSCC | negative regulation of NF-kappaB transcription factor activity | 47/7305 | 93/18723 | 1.55e-02 | 4.99e-02 | 47 |
GO:005109015 | Oral cavity | LP | regulation of DNA-binding transcription factor activity | 147/4623 | 440/18723 | 2.00e-05 | 3.35e-04 | 147 |
GO:0043433 | Oral cavity | LP | negative regulation of DNA-binding transcription factor activity | 61/4623 | 185/18723 | 6.68e-03 | 3.89e-02 | 61 |
GO:005109021 | Oral cavity | EOLP | regulation of DNA-binding transcription factor activity | 80/2218 | 440/18723 | 5.77e-05 | 7.31e-04 | 80 |
GO:00320881 | Oral cavity | EOLP | negative regulation of NF-kappaB transcription factor activity | 22/2218 | 93/18723 | 1.05e-03 | 7.77e-03 | 22 |
GO:00434331 | Oral cavity | EOLP | negative regulation of DNA-binding transcription factor activity | 36/2218 | 185/18723 | 1.79e-03 | 1.17e-02 | 36 |
GO:005109031 | Oral cavity | NEOLP | regulation of DNA-binding transcription factor activity | 72/2005 | 440/18723 | 1.66e-04 | 1.84e-03 | 72 |
GO:00510906 | Prostate | BPH | regulation of DNA-binding transcription factor activity | 100/3107 | 440/18723 | 4.71e-04 | 3.37e-03 | 100 |
GO:005109014 | Prostate | Tumor | regulation of DNA-binding transcription factor activity | 105/3246 | 440/18723 | 2.69e-04 | 2.23e-03 | 105 |
GO:00510909 | Skin | AK | regulation of DNA-binding transcription factor activity | 66/1910 | 440/18723 | 8.99e-04 | 7.40e-03 | 66 |
GO:005109016 | Thyroid | PTC | regulation of DNA-binding transcription factor activity | 178/5968 | 440/18723 | 7.63e-05 | 6.54e-04 | 178 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04137 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041371 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041372 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041373 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041378 | Colorectum | FAP | Mitophagy - animal | 20/1404 | 72/8465 | 1.14e-02 | 3.92e-02 | 2.38e-02 | 20 |
hsa041379 | Colorectum | FAP | Mitophagy - animal | 20/1404 | 72/8465 | 1.14e-02 | 3.92e-02 | 2.38e-02 | 20 |
hsa0413710 | Colorectum | CRC | Mitophagy - animal | 17/1091 | 72/8465 | 8.74e-03 | 4.00e-02 | 2.71e-02 | 17 |
hsa0413711 | Colorectum | CRC | Mitophagy - animal | 17/1091 | 72/8465 | 8.74e-03 | 4.00e-02 | 2.71e-02 | 17 |
hsa0413730 | Esophagus | HGIN | Mitophagy - animal | 23/1383 | 72/8465 | 7.69e-04 | 7.59e-03 | 6.03e-03 | 23 |
hsa04137113 | Esophagus | HGIN | Mitophagy - animal | 23/1383 | 72/8465 | 7.69e-04 | 7.59e-03 | 6.03e-03 | 23 |
hsa04137210 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413738 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413712 | Liver | NAFLD | Mitophagy - animal | 18/1043 | 72/8465 | 2.27e-03 | 2.46e-02 | 1.99e-02 | 18 |
hsa0413713 | Liver | NAFLD | Mitophagy - animal | 18/1043 | 72/8465 | 2.27e-03 | 2.46e-02 | 1.99e-02 | 18 |
hsa0413721 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413731 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413714 | Lung | IAC | Mitophagy - animal | 19/1053 | 72/8465 | 9.72e-04 | 7.32e-03 | 4.86e-03 | 19 |
hsa0413715 | Lung | IAC | Mitophagy - animal | 19/1053 | 72/8465 | 9.72e-04 | 7.32e-03 | 4.86e-03 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAX1BP1 | SNV | Missense_Mutation | novel | c.1009N>G | p.Arg337Gly | p.R337G | Q86VP1 | protein_coding | deleterious(0) | possibly_damaging(0.676) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAX1BP1 | SNV | Missense_Mutation | rs534603306 | c.1322N>A | p.Arg441His | p.R441H | Q86VP1 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TAX1BP1 | SNV | Missense_Mutation | novel | c.1590N>C | p.Glu530Asp | p.E530D | Q86VP1 | protein_coding | tolerated(0.15) | benign(0.418) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TAX1BP1 | SNV | Missense_Mutation | novel | c.749C>A | p.Thr250Asn | p.T250N | Q86VP1 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAX1BP1 | insertion | Frame_Shift_Ins | novel | c.2362_2363insCAATTTTACAATTAGA | p.Phe788SerfsTer7 | p.F788Sfs*7 | Q86VP1 | protein_coding | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TAX1BP1 | SNV | Missense_Mutation | rs550822476 | c.947N>G | p.Thr316Ser | p.T316S | Q86VP1 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
TAX1BP1 | SNV | Missense_Mutation | novel | c.1774N>G | p.Arg592Gly | p.R592G | Q86VP1 | protein_coding | tolerated(0.1) | benign(0) | TCGA-44-7659-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TAX1BP1 | SNV | Missense_Mutation | c.1367G>C | p.Cys456Ser | p.C456S | Q86VP1 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TAX1BP1 | SNV | Missense_Mutation | c.1141N>C | p.Val381Leu | p.V381L | Q86VP1 | protein_coding | tolerated(0.09) | possibly_damaging(0.867) | TCGA-MP-A4TA-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TAX1BP1 | SNV | Missense_Mutation | novel | c.784N>A | p.Ala262Thr | p.A262T | Q86VP1 | protein_coding | tolerated(0.08) | benign(0.102) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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