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Gene: TANC2 |
Gene summary for TANC2 |
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Gene information | Species | Human | Gene symbol | TANC2 | Gene ID | 26115 |
Gene name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | |
Gene Alias | IDDALDS | |
Cytomap | 17q23.2-q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9HCD6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26115 | TANC2 | CCI_1 | Human | Cervix | CC | 3.47e-13 | 7.35e-01 | 0.528 |
26115 | TANC2 | CCI_2 | Human | Cervix | CC | 3.17e-07 | 1.00e+00 | 0.5249 |
26115 | TANC2 | CCI_3 | Human | Cervix | CC | 3.98e-21 | 1.05e+00 | 0.516 |
26115 | TANC2 | CCII_1 | Human | Cervix | CC | 3.17e-18 | 6.93e-01 | 0.3249 |
26115 | TANC2 | LZE4T | Human | Esophagus | ESCC | 5.81e-07 | 1.90e-01 | 0.0811 |
26115 | TANC2 | LZE24T | Human | Esophagus | ESCC | 1.33e-13 | 3.54e-01 | 0.0596 |
26115 | TANC2 | P1T-E | Human | Esophagus | ESCC | 2.58e-12 | 1.00e+00 | 0.0875 |
26115 | TANC2 | P2T-E | Human | Esophagus | ESCC | 7.13e-03 | 4.44e-02 | 0.1177 |
26115 | TANC2 | P5T-E | Human | Esophagus | ESCC | 5.66e-11 | 1.11e-01 | 0.1327 |
26115 | TANC2 | P8T-E | Human | Esophagus | ESCC | 3.21e-27 | 4.76e-01 | 0.0889 |
26115 | TANC2 | P9T-E | Human | Esophagus | ESCC | 1.79e-06 | 1.60e-01 | 0.1131 |
26115 | TANC2 | P10T-E | Human | Esophagus | ESCC | 8.18e-07 | 1.14e-01 | 0.116 |
26115 | TANC2 | P11T-E | Human | Esophagus | ESCC | 4.71e-07 | 4.17e-01 | 0.1426 |
26115 | TANC2 | P12T-E | Human | Esophagus | ESCC | 1.55e-08 | 1.48e-01 | 0.1122 |
26115 | TANC2 | P15T-E | Human | Esophagus | ESCC | 1.38e-09 | 1.80e-01 | 0.1149 |
26115 | TANC2 | P16T-E | Human | Esophagus | ESCC | 2.53e-11 | 1.44e-01 | 0.1153 |
26115 | TANC2 | P17T-E | Human | Esophagus | ESCC | 9.87e-03 | 2.83e-01 | 0.1278 |
26115 | TANC2 | P21T-E | Human | Esophagus | ESCC | 1.43e-06 | 1.12e-01 | 0.1617 |
26115 | TANC2 | P22T-E | Human | Esophagus | ESCC | 1.11e-07 | 1.17e-01 | 0.1236 |
26115 | TANC2 | P23T-E | Human | Esophagus | ESCC | 1.03e-11 | 3.33e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:00609984 | Cervix | CC | regulation of dendritic spine development | 18/2311 | 61/18723 | 2.84e-04 | 3.07e-03 | 18 |
GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
GO:00488135 | Cervix | CC | dendrite morphogenesis | 30/2311 | 146/18723 | 3.27e-03 | 2.13e-02 | 30 |
GO:01060277 | Cervix | CC | neuron projection organization | 21/2311 | 93/18723 | 4.10e-03 | 2.54e-02 | 21 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:00610014 | Cervix | CC | regulation of dendritic spine morphogenesis | 12/2311 | 47/18723 | 1.01e-02 | 4.91e-02 | 12 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00995185 | Esophagus | ESCC | vesicle cytoskeletal trafficking | 50/8552 | 73/18723 | 6.75e-05 | 5.12e-04 | 50 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TANC2 | SNV | Missense_Mutation | rs368122235 | c.3226C>T | p.Arg1076Cys | p.R1076C | Q9HCD6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TANC2 | SNV | Missense_Mutation | rs767165738 | c.1513N>T | p.Arg505Cys | p.R505C | Q9HCD6 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TANC2 | SNV | Missense_Mutation | rs372803024 | c.3859C>T | p.Arg1287Trp | p.R1287W | Q9HCD6 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TANC2 | SNV | Missense_Mutation | novel | c.3358N>T | p.Leu1120Phe | p.L1120F | Q9HCD6 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TANC2 | SNV | Missense_Mutation | c.794N>A | p.Arg265Gln | p.R265Q | Q9HCD6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TANC2 | SNV | Missense_Mutation | c.5767N>T | p.His1923Tyr | p.H1923Y | Q9HCD6 | protein_coding | tolerated_low_confidence(0.19) | benign(0.099) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TANC2 | SNV | Missense_Mutation | c.881N>A | p.Ser294Tyr | p.S294Y | Q9HCD6 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TANC2 | SNV | Missense_Mutation | c.1326G>T | p.Glu442Asp | p.E442D | Q9HCD6 | protein_coding | tolerated(0.18) | benign(0.103) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TANC2 | SNV | Missense_Mutation | c.2915N>G | p.Gln972Arg | p.Q972R | Q9HCD6 | protein_coding | tolerated(0.31) | benign(0.038) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TANC2 | SNV | Missense_Mutation | c.5008G>A | p.Asp1670Asn | p.D1670N | Q9HCD6 | protein_coding | tolerated_low_confidence(0.09) | probably_damaging(0.971) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26115 | TANC2 | NA | calcium channel blockers | 24192120 |
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