![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SYMPK |
Gene summary for SYMPK |
![]() |
Gene information | Species | Human | Gene symbol | SYMPK | Gene ID | 8189 |
Gene name | symplekin scaffold protein | |
Gene Alias | Pta1 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0R6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8189 | SYMPK | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.06e-06 | 5.74e-01 | -0.059 |
8189 | SYMPK | HTA11_866_3004761011 | Human | Colorectum | AD | 6.92e-04 | 4.00e-01 | 0.096 |
8189 | SYMPK | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.07e-04 | 5.63e-01 | 0.0338 |
8189 | SYMPK | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.23e-21 | 8.54e-01 | 0.0674 |
8189 | SYMPK | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.75e-03 | 6.38e-01 | 0.0112 |
8189 | SYMPK | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.21e-06 | 6.11e-01 | 0.0588 |
8189 | SYMPK | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.09e-06 | 6.30e-01 | 0.3859 |
8189 | SYMPK | A015-C-203 | Human | Colorectum | FAP | 2.85e-20 | 2.24e-01 | -0.1294 |
8189 | SYMPK | A002-C-201 | Human | Colorectum | FAP | 1.50e-09 | 3.12e-01 | 0.0324 |
8189 | SYMPK | A001-C-108 | Human | Colorectum | FAP | 2.62e-07 | 5.96e-02 | -0.0272 |
8189 | SYMPK | A002-C-205 | Human | Colorectum | FAP | 1.43e-11 | 7.15e-03 | -0.1236 |
8189 | SYMPK | A015-C-006 | Human | Colorectum | FAP | 1.10e-06 | 6.44e-02 | -0.0994 |
8189 | SYMPK | A015-C-106 | Human | Colorectum | FAP | 5.41e-06 | 1.96e-01 | -0.0511 |
8189 | SYMPK | A002-C-114 | Human | Colorectum | FAP | 7.22e-08 | 3.03e-02 | -0.1561 |
8189 | SYMPK | A015-C-104 | Human | Colorectum | FAP | 1.26e-18 | 6.89e-02 | -0.1899 |
8189 | SYMPK | A001-C-014 | Human | Colorectum | FAP | 5.33e-04 | -5.48e-02 | 0.0135 |
8189 | SYMPK | A002-C-016 | Human | Colorectum | FAP | 1.09e-07 | -7.77e-02 | 0.0521 |
8189 | SYMPK | A015-C-002 | Human | Colorectum | FAP | 2.33e-04 | 2.81e-02 | -0.0763 |
8189 | SYMPK | A001-C-203 | Human | Colorectum | FAP | 3.58e-02 | -3.70e-04 | -0.0481 |
8189 | SYMPK | A002-C-116 | Human | Colorectum | FAP | 6.12e-18 | -1.76e-01 | -0.0452 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0035303 | Colorectum | AD | regulation of dephosphorylation | 46/3918 | 128/18723 | 6.20e-05 | 1.04e-03 | 46 |
GO:0035304 | Colorectum | AD | regulation of protein dephosphorylation | 33/3918 | 90/18723 | 4.23e-04 | 4.77e-03 | 33 |
GO:0051100 | Colorectum | AD | negative regulation of binding | 50/3918 | 162/18723 | 1.84e-03 | 1.51e-02 | 50 |
GO:0035306 | Colorectum | AD | positive regulation of dephosphorylation | 22/3918 | 59/18723 | 2.86e-03 | 2.14e-02 | 22 |
GO:0032091 | Colorectum | AD | negative regulation of protein binding | 30/3918 | 94/18723 | 8.26e-03 | 4.85e-02 | 30 |
GO:00510982 | Colorectum | MSS | regulation of binding | 113/3467 | 363/18723 | 3.55e-09 | 2.41e-07 | 113 |
GO:00433932 | Colorectum | MSS | regulation of protein binding | 62/3467 | 196/18723 | 6.44e-06 | 1.69e-04 | 62 |
GO:00353032 | Colorectum | MSS | regulation of dephosphorylation | 41/3467 | 128/18723 | 1.64e-04 | 2.33e-03 | 41 |
GO:00353042 | Colorectum | MSS | regulation of protein dephosphorylation | 30/3467 | 90/18723 | 5.58e-04 | 6.19e-03 | 30 |
GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
GO:00511002 | Colorectum | MSS | negative regulation of binding | 44/3467 | 162/18723 | 4.26e-03 | 3.04e-02 | 44 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
GO:00064704 | Colorectum | FAP | protein dephosphorylation | 69/2622 | 281/18723 | 1.47e-06 | 6.39e-05 | 69 |
GO:00510984 | Colorectum | FAP | regulation of binding | 81/2622 | 363/18723 | 1.04e-05 | 2.97e-04 | 81 |
GO:00353034 | Colorectum | FAP | regulation of dephosphorylation | 36/2622 | 128/18723 | 2.22e-05 | 5.28e-04 | 36 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa045308 | Colorectum | FAP | Tight junction | 60/1404 | 169/8465 | 1.40e-09 | 9.33e-08 | 5.67e-08 | 60 |
hsa030152 | Colorectum | FAP | mRNA surveillance pathway | 26/1404 | 97/8465 | 7.11e-03 | 2.64e-02 | 1.60e-02 | 26 |
hsa045309 | Colorectum | FAP | Tight junction | 60/1404 | 169/8465 | 1.40e-09 | 9.33e-08 | 5.67e-08 | 60 |
hsa030153 | Colorectum | FAP | mRNA surveillance pathway | 26/1404 | 97/8465 | 7.11e-03 | 2.64e-02 | 1.60e-02 | 26 |
hsa0453010 | Colorectum | CRC | Tight junction | 44/1091 | 169/8465 | 2.51e-06 | 7.61e-05 | 5.16e-05 | 44 |
hsa0453011 | Colorectum | CRC | Tight junction | 44/1091 | 169/8465 | 2.51e-06 | 7.61e-05 | 5.16e-05 | 44 |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa04530310 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa0453042 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0301521 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa0453052 | Liver | HCC | Tight junction | 110/4020 | 169/8465 | 2.45e-06 | 2.28e-05 | 1.27e-05 | 110 |
hsa0301531 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa030158 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0453030 | Oral cavity | OSCC | Tight junction | 102/3704 | 169/8465 | 8.68e-06 | 3.93e-05 | 2.00e-05 | 102 |
hsa0301513 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa04530114 | Oral cavity | OSCC | Tight junction | 102/3704 | 169/8465 | 8.68e-06 | 3.93e-05 | 2.00e-05 | 102 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYMPK | SNV | Missense_Mutation | rs781582819 | c.2071N>T | p.Arg691Cys | p.R691C | Q92797 | protein_coding | tolerated(0.08) | possibly_damaging(0.485) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SYMPK | SNV | Missense_Mutation | c.1880N>G | p.Tyr627Cys | p.Y627C | Q92797 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SYMPK | SNV | Missense_Mutation | novel | c.2146G>A | p.Val716Ile | p.V716I | Q92797 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SYMPK | SNV | Missense_Mutation | c.2461N>T | p.Arg821Trp | p.R821W | Q92797 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SYMPK | SNV | Missense_Mutation | novel | c.350T>G | p.Leu117Arg | p.L117R | Q92797 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SYMPK | SNV | Missense_Mutation | c.2508N>T | p.Met836Ile | p.M836I | Q92797 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SYMPK | SNV | Missense_Mutation | novel | c.571N>G | p.Ile191Val | p.I191V | Q92797 | protein_coding | tolerated(0.56) | benign(0.03) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SYMPK | SNV | Missense_Mutation | novel | c.86N>A | p.Gly29Asp | p.G29D | Q92797 | protein_coding | tolerated(0.58) | benign(0.001) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SYMPK | SNV | Missense_Mutation | novel | c.1471C>T | p.Arg491Trp | p.R491W | Q92797 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SYMPK | SNV | Missense_Mutation | novel | c.892N>T | p.Arg298Cys | p.R298C | Q92797 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |