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Gene: SRP68 |
Gene summary for SRP68 |
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Gene information | Species | Human | Gene symbol | SRP68 | Gene ID | 6730 |
Gene name | signal recognition particle 68 | |
Gene Alias | SRP68 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q9UHB9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6730 | SRP68 | LZE2T | Human | Esophagus | ESCC | 3.57e-04 | 3.81e-01 | 0.082 |
6730 | SRP68 | LZE4T | Human | Esophagus | ESCC | 6.85e-13 | 2.34e-01 | 0.0811 |
6730 | SRP68 | LZE7T | Human | Esophagus | ESCC | 4.06e-02 | 2.34e-01 | 0.0667 |
6730 | SRP68 | LZE20T | Human | Esophagus | ESCC | 3.94e-06 | 1.21e-01 | 0.0662 |
6730 | SRP68 | LZE24T | Human | Esophagus | ESCC | 3.20e-10 | 4.22e-01 | 0.0596 |
6730 | SRP68 | P2T-E | Human | Esophagus | ESCC | 9.84e-34 | 5.17e-01 | 0.1177 |
6730 | SRP68 | P4T-E | Human | Esophagus | ESCC | 3.92e-17 | 3.53e-01 | 0.1323 |
6730 | SRP68 | P5T-E | Human | Esophagus | ESCC | 7.76e-12 | 8.93e-02 | 0.1327 |
6730 | SRP68 | P8T-E | Human | Esophagus | ESCC | 2.36e-18 | 3.61e-01 | 0.0889 |
6730 | SRP68 | P9T-E | Human | Esophagus | ESCC | 5.50e-13 | 3.46e-01 | 0.1131 |
6730 | SRP68 | P10T-E | Human | Esophagus | ESCC | 3.42e-21 | 3.59e-01 | 0.116 |
6730 | SRP68 | P11T-E | Human | Esophagus | ESCC | 5.11e-19 | 1.00e+00 | 0.1426 |
6730 | SRP68 | P12T-E | Human | Esophagus | ESCC | 9.04e-33 | 7.38e-01 | 0.1122 |
6730 | SRP68 | P15T-E | Human | Esophagus | ESCC | 2.31e-27 | 6.99e-01 | 0.1149 |
6730 | SRP68 | P16T-E | Human | Esophagus | ESCC | 5.29e-32 | 5.69e-01 | 0.1153 |
6730 | SRP68 | P17T-E | Human | Esophagus | ESCC | 8.63e-11 | 5.34e-01 | 0.1278 |
6730 | SRP68 | P19T-E | Human | Esophagus | ESCC | 7.48e-08 | 6.54e-01 | 0.1662 |
6730 | SRP68 | P20T-E | Human | Esophagus | ESCC | 6.34e-46 | 1.24e+00 | 0.1124 |
6730 | SRP68 | P21T-E | Human | Esophagus | ESCC | 1.06e-26 | 4.90e-01 | 0.1617 |
6730 | SRP68 | P22T-E | Human | Esophagus | ESCC | 5.09e-25 | 5.12e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:007097218 | Esophagus | ESCC | protein localization to endoplasmic reticulum | 52/8552 | 74/18723 | 1.58e-05 | 1.42e-04 | 52 |
GO:00066124 | Esophagus | ESCC | protein targeting to membrane | 83/8552 | 131/18723 | 3.31e-05 | 2.73e-04 | 83 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:007259915 | Esophagus | ESCC | establishment of protein localization to endoplasmic reticulum | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:004504715 | Esophagus | ESCC | protein targeting to ER | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:007097212 | Liver | HCC | protein localization to endoplasmic reticulum | 54/7958 | 74/18723 | 1.01e-07 | 1.98e-06 | 54 |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
GO:007259911 | Liver | HCC | establishment of protein localization to endoplasmic reticulum | 34/7958 | 46/18723 | 1.53e-05 | 1.67e-04 | 34 |
GO:004504711 | Liver | HCC | protein targeting to ER | 30/7958 | 42/18723 | 1.40e-04 | 1.13e-03 | 30 |
GO:00066121 | Liver | HCC | protein targeting to membrane | 75/7958 | 131/18723 | 4.58e-04 | 3.04e-03 | 75 |
GO:00066131 | Liver | HCC | cotranslational protein targeting to membrane | 20/7958 | 31/18723 | 1.11e-02 | 4.09e-02 | 20 |
GO:007259418 | Oral cavity | OSCC | establishment of protein localization to organelle | 284/7305 | 422/18723 | 1.50e-32 | 1.35e-29 | 284 |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:009015018 | Oral cavity | OSCC | establishment of protein localization to membrane | 163/7305 | 260/18723 | 7.13e-15 | 4.47e-13 | 163 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0306026 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa0306036 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa0306021 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306031 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306018 | Oral cavity | OSCC | Protein export | 21/3704 | 23/8465 | 2.42e-06 | 1.27e-05 | 6.45e-06 | 21 |
hsa0306019 | Oral cavity | OSCC | Protein export | 21/3704 | 23/8465 | 2.42e-06 | 1.27e-05 | 6.45e-06 | 21 |
hsa0306025 | Oral cavity | LP | Protein export | 21/2418 | 23/8465 | 4.72e-10 | 8.28e-09 | 5.34e-09 | 21 |
hsa0306035 | Oral cavity | LP | Protein export | 21/2418 | 23/8465 | 4.72e-10 | 8.28e-09 | 5.34e-09 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRP68 | SNV | Missense_Mutation | c.710N>C | p.Val237Ala | p.V237A | Q9UHB9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
SRP68 | SNV | Missense_Mutation | c.1741T>C | p.Phe581Leu | p.F581L | Q9UHB9 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SRP68 | SNV | Missense_Mutation | c.479G>A | p.Arg160His | p.R160H | Q9UHB9 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SRP68 | SNV | Missense_Mutation | rs781574834 | c.1588N>A | p.Ala530Thr | p.A530T | Q9UHB9 | protein_coding | tolerated(0.39) | benign(0.32) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
SRP68 | SNV | Missense_Mutation | novel | c.1271N>C | p.Leu424Pro | p.L424P | Q9UHB9 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SRP68 | SNV | Missense_Mutation | novel | c.53G>C | p.Gly18Ala | p.G18A | Q9UHB9 | protein_coding | tolerated_low_confidence(0.15) | benign(0.013) | TCGA-VQ-A8PU-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
SRP68 | SNV | Missense_Mutation | novel | c.1055G>T | p.Arg352Leu | p.R352L | Q9UHB9 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-BJ-A191-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRP68 | SNV | Missense_Mutation | novel | c.581N>T | p.Ser194Leu | p.S194L | Q9UHB9 | protein_coding | tolerated(0.3) | benign(0.053) | TCGA-EL-A3ZO-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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