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Gene: SPATA6 |
Gene summary for SPATA6 |
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Gene information | Species | Human | Gene symbol | SPATA6 | Gene ID | 54558 |
Gene name | spermatogenesis associated 6 | |
Gene Alias | HASH | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NWH7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54558 | SPATA6 | LZE24T | Human | Esophagus | ESCC | 7.61e-04 | 2.06e-01 | 0.0596 |
54558 | SPATA6 | P1T-E | Human | Esophagus | ESCC | 3.97e-06 | 2.07e-01 | 0.0875 |
54558 | SPATA6 | P2T-E | Human | Esophagus | ESCC | 3.24e-37 | 5.57e-01 | 0.1177 |
54558 | SPATA6 | P8T-E | Human | Esophagus | ESCC | 1.36e-05 | 8.15e-02 | 0.0889 |
54558 | SPATA6 | P10T-E | Human | Esophagus | ESCC | 9.05e-09 | 1.44e-01 | 0.116 |
54558 | SPATA6 | P11T-E | Human | Esophagus | ESCC | 5.38e-14 | 3.42e-01 | 0.1426 |
54558 | SPATA6 | P16T-E | Human | Esophagus | ESCC | 3.60e-10 | 1.86e-01 | 0.1153 |
54558 | SPATA6 | P19T-E | Human | Esophagus | ESCC | 3.36e-03 | 3.12e-01 | 0.1662 |
54558 | SPATA6 | P20T-E | Human | Esophagus | ESCC | 5.86e-09 | 1.44e-01 | 0.1124 |
54558 | SPATA6 | P21T-E | Human | Esophagus | ESCC | 3.46e-06 | 1.15e-01 | 0.1617 |
54558 | SPATA6 | P22T-E | Human | Esophagus | ESCC | 1.35e-04 | 7.30e-02 | 0.1236 |
54558 | SPATA6 | P24T-E | Human | Esophagus | ESCC | 7.48e-05 | 1.39e-01 | 0.1287 |
54558 | SPATA6 | P26T-E | Human | Esophagus | ESCC | 1.61e-06 | 1.18e-01 | 0.1276 |
54558 | SPATA6 | P27T-E | Human | Esophagus | ESCC | 2.41e-03 | 6.67e-02 | 0.1055 |
54558 | SPATA6 | P30T-E | Human | Esophagus | ESCC | 1.85e-04 | 9.96e-02 | 0.137 |
54558 | SPATA6 | P32T-E | Human | Esophagus | ESCC | 1.91e-05 | 1.43e-01 | 0.1666 |
54558 | SPATA6 | P36T-E | Human | Esophagus | ESCC | 6.25e-04 | 9.47e-02 | 0.1187 |
54558 | SPATA6 | P39T-E | Human | Esophagus | ESCC | 3.69e-06 | 7.77e-02 | 0.0894 |
54558 | SPATA6 | P42T-E | Human | Esophagus | ESCC | 9.10e-03 | 1.27e-01 | 0.1175 |
54558 | SPATA6 | P44T-E | Human | Esophagus | ESCC | 4.20e-06 | 1.31e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA6 | SNV | Missense_Mutation | novel | c.410N>G | p.Asn137Ser | p.N137S | Q9NWH7 | protein_coding | deleterious(0) | benign(0) | TCGA-HD-7832-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | rs148746931 | c.1144N>T | p.Arg382Trp | p.R382W | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
SPATA6 | SNV | Missense_Mutation | rs187921034 | c.703N>T | p.Arg235Trp | p.R235W | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-4371-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | c.1189N>G | p.Leu397Val | p.L397V | Q9NWH7 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
SPATA6 | SNV | Missense_Mutation | rs748102929 | c.673N>T | p.Arg225Cys | p.R225C | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SPATA6 | SNV | Missense_Mutation | novel | c.400N>A | p.Leu134Ile | p.L134I | Q9NWH7 | protein_coding | tolerated(0.06) | possibly_damaging(0.887) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SPATA6 | SNV | Missense_Mutation | novel | c.581C>T | p.Pro194Leu | p.P194L | Q9NWH7 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
SPATA6 | insertion | Frame_Shift_Ins | novel | c.614_615insA | p.Asn205LysfsTer24 | p.N205Kfs*24 | Q9NWH7 | protein_coding | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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