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Gene: SLC7A2 |
Gene summary for SLC7A2 |
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Gene information | Species | Human | Gene symbol | SLC7A2 | Gene ID | 6542 |
Gene name | solute carrier family 7 member 2 | |
Gene Alias | ATRC2 | |
Cytomap | 8p22 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P52569 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6542 | SLC7A2 | GSM4909282 | Human | Breast | IDC | 1.20e-02 | -1.66e-01 | -0.0288 |
6542 | SLC7A2 | GSM4909285 | Human | Breast | IDC | 4.45e-03 | -1.73e-01 | 0.21 |
6542 | SLC7A2 | GSM4909286 | Human | Breast | IDC | 7.79e-05 | -1.80e-01 | 0.1081 |
6542 | SLC7A2 | GSM4909287 | Human | Breast | IDC | 7.40e-03 | -1.76e-01 | 0.2057 |
6542 | SLC7A2 | GSM4909290 | Human | Breast | IDC | 8.79e-03 | -1.80e-01 | 0.2096 |
6542 | SLC7A2 | GSM4909293 | Human | Breast | IDC | 3.66e-05 | -1.64e-01 | 0.1581 |
6542 | SLC7A2 | GSM4909298 | Human | Breast | IDC | 1.65e-04 | -1.80e-01 | 0.1551 |
6542 | SLC7A2 | GSM4909301 | Human | Breast | IDC | 1.27e-36 | 8.28e-01 | 0.1577 |
6542 | SLC7A2 | GSM4909302 | Human | Breast | IDC | 9.88e-40 | 8.96e-01 | 0.1545 |
6542 | SLC7A2 | GSM4909304 | Human | Breast | IDC | 2.11e-02 | 1.77e-01 | 0.1636 |
6542 | SLC7A2 | GSM4909307 | Human | Breast | IDC | 5.89e-07 | 3.48e-01 | 0.1569 |
6542 | SLC7A2 | GSM4909308 | Human | Breast | IDC | 5.66e-11 | 4.06e-01 | 0.158 |
6542 | SLC7A2 | GSM4909311 | Human | Breast | IDC | 3.66e-05 | -1.80e-01 | 0.1534 |
6542 | SLC7A2 | GSM4909312 | Human | Breast | IDC | 7.79e-05 | -1.80e-01 | 0.1552 |
6542 | SLC7A2 | GSM4909319 | Human | Breast | IDC | 7.79e-05 | -1.80e-01 | 0.1563 |
6542 | SLC7A2 | brca1 | Human | Breast | Precancer | 8.07e-06 | -1.74e-01 | -0.0338 |
6542 | SLC7A2 | M1 | Human | Breast | IDC | 2.71e-15 | 5.67e-01 | 0.1577 |
6542 | SLC7A2 | NCCBC11 | Human | Breast | DCIS | 4.53e-08 | 6.97e-01 | 0.1232 |
6542 | SLC7A2 | NCCBC14 | Human | Breast | DCIS | 4.80e-02 | -1.24e-01 | 0.2021 |
6542 | SLC7A2 | P1 | Human | Breast | IDC | 4.39e-04 | 2.53e-01 | 0.1527 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00030182 | Liver | NAFLD | vascular process in circulatory system | 46/1882 | 263/18723 | 1.36e-04 | 2.58e-03 | 46 |
GO:01501043 | Liver | NAFLD | transport across blood-brain barrier | 17/1882 | 87/18723 | 5.46e-03 | 4.20e-02 | 17 |
GO:00102322 | Liver | NAFLD | vascular transport | 17/1882 | 88/18723 | 6.15e-03 | 4.61e-02 | 17 |
GO:015010411 | Liver | HCC | transport across blood-brain barrier | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:001023211 | Liver | HCC | vascular transport | 50/7958 | 88/18723 | 4.69e-03 | 2.02e-02 | 50 |
GO:00030183 | Prostate | Tumor | vascular process in circulatory system | 61/3246 | 263/18723 | 8.88e-03 | 3.84e-02 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A2 | SNV | Missense_Mutation | rs774560294 | c.407N>T | p.Thr136Met | p.T136M | P52569 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SLC7A2 | SNV | Missense_Mutation | novel | c.1839N>G | p.Ile613Met | p.I613M | P52569 | protein_coding | deleterious(0.01) | possibly_damaging(0.476) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC7A2 | SNV | Missense_Mutation | c.1330C>A | p.Leu444Met | p.L444M | P52569 | protein_coding | deleterious(0.02) | probably_damaging(0.975) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
SLC7A2 | SNV | Missense_Mutation | rs774331805 | c.1579N>G | p.Thr527Ala | p.T527A | P52569 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC7A2 | SNV | Missense_Mutation | rs756005989 | c.964N>T | p.Arg322Trp | p.R322W | P52569 | protein_coding | deleterious(0) | possibly_damaging(0.827) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC7A2 | SNV | Missense_Mutation | rs751863526 | c.269C>T | p.Ala90Val | p.A90V | P52569 | protein_coding | tolerated(0.06) | possibly_damaging(0.873) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC7A2 | SNV | Missense_Mutation | rs369646330 | c.1600G>A | p.Val534Met | p.V534M | P52569 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EO-A3KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
SLC7A2 | SNV | Missense_Mutation | rs777770011 | c.485C>T | p.Ser162Leu | p.S162L | P52569 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC7A2 | deletion | Frame_Shift_Del | c.618delN | p.Phe208LeufsTer9 | p.F208Lfs*9 | P52569 | protein_coding | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SLC7A2 | SNV | Missense_Mutation | c.361N>C | p.Met121Leu | p.M121L | P52569 | protein_coding | tolerated(1) | benign(0.007) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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