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Gene: SLC38A4 |
Gene summary for SLC38A4 |
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Gene information | Species | Human | Gene symbol | SLC38A4 | Gene ID | 55089 |
Gene name | solute carrier family 38 member 4 | |
Gene Alias | ATA3 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | A0A024R0X7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55089 | SLC38A4 | NAFLD1 | Human | Liver | NAFLD | 3.88e-12 | 9.39e-01 | -0.04 |
55089 | SLC38A4 | S41 | Human | Liver | Cirrhotic | 6.72e-06 | 8.65e-01 | -0.0343 |
55089 | SLC38A4 | S43 | Human | Liver | Cirrhotic | 1.11e-04 | -2.39e-01 | -0.0187 |
55089 | SLC38A4 | HCC1_Meng | Human | Liver | HCC | 1.25e-96 | 2.81e-02 | 0.0246 |
55089 | SLC38A4 | HCC2_Meng | Human | Liver | HCC | 2.09e-11 | -3.68e-01 | 0.0107 |
55089 | SLC38A4 | cirrhotic1 | Human | Liver | Cirrhotic | 1.48e-09 | -3.62e-01 | 0.0202 |
55089 | SLC38A4 | cirrhotic2 | Human | Liver | Cirrhotic | 6.08e-06 | -3.20e-01 | 0.0201 |
55089 | SLC38A4 | HCC2 | Human | Liver | HCC | 2.09e-15 | 3.34e+00 | 0.5341 |
55089 | SLC38A4 | Pt13.a | Human | Liver | HCC | 1.64e-04 | -2.91e-01 | 0.021 |
55089 | SLC38A4 | Pt13.b | Human | Liver | HCC | 5.88e-06 | -2.45e-01 | 0.0251 |
55089 | SLC38A4 | Pt14.b | Human | Liver | HCC | 1.39e-02 | -2.28e-02 | 0.018 |
55089 | SLC38A4 | Pt14.d | Human | Liver | HCC | 3.37e-05 | -2.97e-01 | 0.0143 |
55089 | SLC38A4 | HTA12-25-1 | Human | Pancreas | PDAC | 3.77e-05 | 5.13e-01 | 0.313 |
55089 | SLC38A4 | HTA12-26-1 | Human | Pancreas | PDAC | 1.48e-12 | 6.53e-01 | 0.3728 |
55089 | SLC38A4 | HTA12-29-1 | Human | Pancreas | PDAC | 1.33e-15 | 4.20e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC38A4 | SNV | Missense_Mutation | novel | c.352N>G | p.Leu118Val | p.L118V | Q969I6 | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SLC38A4 | SNV | Missense_Mutation | novel | c.1520N>G | p.Phe507Cys | p.F507C | Q969I6 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC38A4 | SNV | Missense_Mutation | novel | c.998C>T | p.Ala333Val | p.A333V | Q969I6 | protein_coding | tolerated(0.52) | benign(0.085) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC38A4 | SNV | Missense_Mutation | c.916C>T | p.Leu306Phe | p.L306F | Q969I6 | protein_coding | tolerated(0.42) | benign(0.012) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC38A4 | SNV | Missense_Mutation | novel | c.200C>A | p.Ala67Asp | p.A67D | Q969I6 | protein_coding | tolerated(0.52) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC38A4 | SNV | Missense_Mutation | c.686N>A | p.Ser229Tyr | p.S229Y | Q969I6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC38A4 | insertion | Nonsense_Mutation | novel | c.725_726insGTG | p.Tyr242delinsTer | p.Y242delins* | Q969I6 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC38A4 | insertion | Nonsense_Mutation | novel | c.724_725insGGCATTCATGAT | p.Ile241_Tyr242insTrpHisSerTer | p.I241_Y242insWHS* | Q969I6 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC38A4 | insertion | In_Frame_Ins | novel | c.1104_1105insGTT | p.Ser368_Asn369insVal | p.S368_N369insV | Q969I6 | protein_coding | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC38A4 | SNV | Missense_Mutation | novel | c.100N>A | p.Glu34Lys | p.E34K | Q969I6 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55089 | SLC38A4 | TRANSPORTER | 178101263 | |||
55089 | SLC38A4 | TRANSPORTER | 178100907 | |||
55089 | SLC38A4 | TRANSPORTER | 178101353 | |||
55089 | SLC38A4 | TRANSPORTER | 178101264 |
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