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Gene: SLC22A15 |
Gene summary for SLC22A15 |
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Gene information | Species | Human | Gene symbol | SLC22A15 | Gene ID | 55356 |
Gene name | solute carrier family 22 member 15 | |
Gene Alias | FLIPT1 | |
Cytomap | 1p13.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8IZD6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55356 | SLC22A15 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.26e-12 | 6.50e-01 | -0.2116 |
55356 | SLC22A15 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 5.42e-07 | 6.59e-01 | -0.1941 |
55356 | SLC22A15 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.45e-05 | 5.72e-01 | -0.2107 |
55356 | SLC22A15 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.98e-08 | 5.11e-01 | -0.2119 |
55356 | SLC22A15 | HTA12-23-1 | Human | Pancreas | PDAC | 2.25e-04 | 5.03e-01 | 0.3405 |
55356 | SLC22A15 | HTA12-25-1 | Human | Pancreas | PDAC | 3.68e-04 | 4.26e-01 | 0.313 |
55356 | SLC22A15 | HTA12-26-1 | Human | Pancreas | PDAC | 7.38e-20 | 7.68e-01 | 0.3728 |
55356 | SLC22A15 | HTA12-29-1 | Human | Pancreas | PDAC | 5.31e-31 | 7.00e-01 | 0.3722 |
55356 | SLC22A15 | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 6.91e-01 | 0.3624 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A15 | SNV | Missense_Mutation | novel | c.373N>A | p.Gly125Arg | p.G125R | Q8IZD6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC22A15 | SNV | Missense_Mutation | novel | c.1342A>T | p.Ile448Phe | p.I448F | Q8IZD6 | protein_coding | deleterious(0.01) | benign(0.424) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC22A15 | SNV | Missense_Mutation | c.602C>T | p.Ser201Leu | p.S201L | Q8IZD6 | protein_coding | deleterious(0) | benign(0.251) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
SLC22A15 | SNV | Missense_Mutation | novel | c.682G>A | p.Ala228Thr | p.A228T | Q8IZD6 | protein_coding | tolerated(0.1) | benign(0.086) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
SLC22A15 | deletion | Frame_Shift_Del | novel | c.472delN | p.Ser159ProfsTer9 | p.S159Pfs*9 | Q8IZD6 | protein_coding | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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