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Gene: SLC17A4 |
Gene summary for SLC17A4 |
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Gene information | Species | Human | Gene symbol | SLC17A4 | Gene ID | 10050 |
Gene name | solute carrier family 17 member 4 | |
Gene Alias | KAIA2138 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q9Y2C5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10050 | SLC17A4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.22e-07 | 3.78e-01 | -0.1808 |
10050 | SLC17A4 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.34e-02 | 1.93e-01 | -0.1088 |
10050 | SLC17A4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.78e-16 | 5.64e-01 | -0.1954 |
10050 | SLC17A4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.57e-04 | 5.25e-01 | -0.2196 |
10050 | SLC17A4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.48e-02 | 3.56e-01 | -0.2061 |
10050 | SLC17A4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.76e-11 | 3.81e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC17A4 | insertion | Nonsense_Mutation | novel | c.1096_1097insGATGAGACGTCGGC | p.Ile366ArgfsTer2 | p.I366Rfs*2 | Q9Y2C5 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | insertion | Frame_Shift_Ins | novel | c.890_891insACAAC | p.Leu298GlnfsTer3 | p.L298Qfs*3 | Q9Y2C5 | protein_coding | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | insertion | Frame_Shift_Ins | novel | c.1198_1199insACAGACTGTCCACA | p.Val400AspfsTer44 | p.V400Dfs*44 | Q9Y2C5 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
SLC17A4 | insertion | In_Frame_Ins | novel | c.881_882insTGA | p.Leu294_Trp295insAsp | p.L294_W295insD | Q9Y2C5 | protein_coding | TCGA-BG-A0MS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
SLC17A4 | insertion | Frame_Shift_Ins | novel | c.883_884insTT | p.Trp295PhefsTer5 | p.W295Ffs*5 | Q9Y2C5 | protein_coding | TCGA-BG-A0MS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
SLC17A4 | insertion | In_Frame_Ins | novel | c.1198_1199insACAGAC | p.Val400delinsAspArgLeu | p.V400delinsDRL | Q9Y2C5 | protein_coding | TCGA-BG-A0YU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | insertion | Frame_Shift_Ins | novel | c.881_882insTGACTTTGGC | p.Trp295AspfsTer13 | p.W295Dfs*13 | Q9Y2C5 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | insertion | Nonsense_Mutation | novel | c.41_42insCTAAGTGCCTGTGGGGATGAAGGATGAAGCC | p.Ser15Ter | p.S15* | Q9Y2C5 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | insertion | Frame_Shift_Ins | novel | c.1205_1206insCACAT | p.Ser403ThrfsTer38 | p.S403Tfs*38 | Q9Y2C5 | protein_coding | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | SNV | Missense_Mutation | novel | c.1031N>T | p.Cys344Phe | p.C344F | Q9Y2C5 | protein_coding | tolerated(0.52) | benign(0.01) | TCGA-2Y-A9GX-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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