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Gene: SHOC2 |
Gene summary for SHOC2 |
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Gene information | Species | Human | Gene symbol | SHOC2 | Gene ID | 8036 |
Gene name | SHOC2 leucine rich repeat scaffold protein | |
Gene Alias | NSLH1 | |
Cytomap | 10q25.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9UQ13 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8036 | SHOC2 | LZE4T | Human | Esophagus | ESCC | 2.16e-15 | 4.32e-01 | 0.0811 |
8036 | SHOC2 | LZE5T | Human | Esophagus | ESCC | 2.08e-08 | 3.33e-01 | 0.0514 |
8036 | SHOC2 | LZE7T | Human | Esophagus | ESCC | 5.02e-05 | 1.67e-01 | 0.0667 |
8036 | SHOC2 | LZE8T | Human | Esophagus | ESCC | 3.19e-08 | 1.72e-01 | 0.067 |
8036 | SHOC2 | LZE20T | Human | Esophagus | ESCC | 2.14e-03 | 1.68e-01 | 0.0662 |
8036 | SHOC2 | LZE22T | Human | Esophagus | ESCC | 5.31e-04 | 2.26e-01 | 0.068 |
8036 | SHOC2 | LZE24T | Human | Esophagus | ESCC | 4.54e-16 | 4.35e-01 | 0.0596 |
8036 | SHOC2 | LZE21T | Human | Esophagus | ESCC | 2.87e-04 | 1.95e-01 | 0.0655 |
8036 | SHOC2 | LZE6T | Human | Esophagus | ESCC | 1.66e-02 | 1.38e-01 | 0.0845 |
8036 | SHOC2 | P1T-E | Human | Esophagus | ESCC | 6.42e-08 | 4.58e-01 | 0.0875 |
8036 | SHOC2 | P2T-E | Human | Esophagus | ESCC | 6.12e-17 | 2.27e-01 | 0.1177 |
8036 | SHOC2 | P4T-E | Human | Esophagus | ESCC | 1.38e-23 | 4.15e-01 | 0.1323 |
8036 | SHOC2 | P5T-E | Human | Esophagus | ESCC | 5.97e-25 | 4.33e-01 | 0.1327 |
8036 | SHOC2 | P8T-E | Human | Esophagus | ESCC | 6.86e-29 | 4.86e-01 | 0.0889 |
8036 | SHOC2 | P9T-E | Human | Esophagus | ESCC | 1.76e-13 | 3.08e-01 | 0.1131 |
8036 | SHOC2 | P10T-E | Human | Esophagus | ESCC | 6.06e-10 | 1.37e-01 | 0.116 |
8036 | SHOC2 | P11T-E | Human | Esophagus | ESCC | 2.06e-20 | 5.70e-01 | 0.1426 |
8036 | SHOC2 | P12T-E | Human | Esophagus | ESCC | 1.23e-26 | 4.54e-01 | 0.1122 |
8036 | SHOC2 | P15T-E | Human | Esophagus | ESCC | 1.03e-14 | 2.59e-01 | 0.1149 |
8036 | SHOC2 | P16T-E | Human | Esophagus | ESCC | 6.24e-19 | 2.56e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:000726511 | Liver | Cirrhotic | Ras protein signal transduction | 119/4634 | 337/18723 | 8.16e-06 | 1.22e-04 | 119 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:00465788 | Oral cavity | OSCC | regulation of Ras protein signal transduction | 90/7305 | 189/18723 | 9.58e-03 | 3.40e-02 | 90 |
GO:000726522 | Oral cavity | EOLP | Ras protein signal transduction | 74/2218 | 337/18723 | 8.76e-08 | 3.09e-06 | 74 |
GO:00510569 | Oral cavity | EOLP | regulation of small GTPase mediated signal transduction | 51/2218 | 302/18723 | 5.67e-03 | 2.92e-02 | 51 |
GO:000726531 | Oral cavity | NEOLP | Ras protein signal transduction | 71/2005 | 337/18723 | 1.60e-08 | 7.27e-07 | 71 |
GO:004657815 | Oral cavity | NEOLP | regulation of Ras protein signal transduction | 36/2005 | 189/18723 | 4.30e-04 | 3.92e-03 | 36 |
GO:005105614 | Oral cavity | NEOLP | regulation of small GTPase mediated signal transduction | 49/2005 | 302/18723 | 2.04e-03 | 1.36e-02 | 49 |
GO:000726523 | Skin | cSCC | Ras protein signal transduction | 132/4864 | 337/18723 | 6.17e-08 | 1.57e-06 | 132 |
GO:000726519 | Thyroid | PTC | Ras protein signal transduction | 162/5968 | 337/18723 | 3.16e-10 | 1.02e-08 | 162 |
GO:005105617 | Thyroid | PTC | regulation of small GTPase mediated signal transduction | 132/5968 | 302/18723 | 9.26e-06 | 1.04e-04 | 132 |
GO:004657817 | Thyroid | PTC | regulation of Ras protein signal transduction | 88/5968 | 189/18723 | 1.62e-05 | 1.70e-04 | 88 |
GO:000726524 | Thyroid | ATC | Ras protein signal transduction | 172/6293 | 337/18723 | 2.25e-11 | 7.96e-10 | 172 |
GO:005105618 | Thyroid | ATC | regulation of small GTPase mediated signal transduction | 141/6293 | 302/18723 | 1.43e-06 | 1.77e-05 | 141 |
GO:004657818 | Thyroid | ATC | regulation of Ras protein signal transduction | 94/6293 | 189/18723 | 3.12e-06 | 3.55e-05 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SHOC2 | SNV | Missense_Mutation | c.262G>A | p.Ala88Thr | p.A88T | Q9UQ13 | protein_coding | tolerated(0.62) | benign(0.035) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SHOC2 | SNV | Missense_Mutation | rs864309599 | c.806A>G | p.Gln269Arg | p.Q269R | Q9UQ13 | protein_coding | tolerated(0.08) | probably_damaging(0.993) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SHOC2 | SNV | Missense_Mutation | c.1441N>G | p.Asn481Asp | p.N481D | Q9UQ13 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SHOC2 | SNV | Missense_Mutation | novel | c.148G>A | p.Ala50Thr | p.A50T | Q9UQ13 | protein_coding | tolerated(0.57) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SHOC2 | SNV | Missense_Mutation | novel | c.730N>A | p.Asp244Asn | p.D244N | Q9UQ13 | protein_coding | tolerated(0.1) | possibly_damaging(0.814) | TCGA-VQ-A922-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
SHOC2 | SNV | Missense_Mutation | novel | c.731N>T | p.Asp244Val | p.D244V | Q9UQ13 | protein_coding | tolerated(0.08) | probably_damaging(0.983) | TCGA-VQ-A922-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
SHOC2 | insertion | In_Frame_Ins | novel | c.321_322insGGTTCTTTT | p.Leu107_Ser108insGlySerPhe | p.L107_S108insGSF | Q9UQ13 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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