![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SERBP1 |
Gene summary for SERBP1 |
![]() |
Gene information | Species | Human | Gene symbol | SERBP1 | Gene ID | 26135 |
Gene name | SERPINE1 mRNA binding protein 1 | |
Gene Alias | CGI-55 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NC51 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26135 | SERBP1 | CA_HPV_1 | Human | Cervix | CC | 1.81e-06 | -6.72e-02 | 0.0264 |
26135 | SERBP1 | CA_HPV_3 | Human | Cervix | CC | 1.80e-03 | 1.39e-01 | 0.0414 |
26135 | SERBP1 | N_HPV_2 | Human | Cervix | N_HPV | 1.29e-02 | 1.18e-01 | -0.0131 |
26135 | SERBP1 | CCII_1 | Human | Cervix | CC | 4.19e-29 | -9.19e-01 | 0.3249 |
26135 | SERBP1 | sample1 | Human | Cervix | CC | 4.52e-06 | -4.62e-01 | 0.0959 |
26135 | SERBP1 | sample3 | Human | Cervix | CC | 5.59e-05 | -2.17e-02 | 0.1387 |
26135 | SERBP1 | L1 | Human | Cervix | CC | 2.57e-07 | -6.48e-02 | 0.0802 |
26135 | SERBP1 | T1 | Human | Cervix | CC | 7.57e-20 | -5.51e-01 | 0.0918 |
26135 | SERBP1 | T3 | Human | Cervix | CC | 1.03e-03 | -1.22e-02 | 0.1389 |
26135 | SERBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.90e-07 | 6.91e-01 | -0.0811 |
26135 | SERBP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.61e-08 | 6.90e-01 | -0.1088 |
26135 | SERBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.40e-22 | 9.97e-01 | -0.1954 |
26135 | SERBP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.40e-04 | 6.10e-01 | -0.1526 |
26135 | SERBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-10 | 6.40e-01 | -0.1464 |
26135 | SERBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.04e-05 | 4.79e-01 | -0.1001 |
26135 | SERBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.08e-12 | 9.71e-01 | -0.059 |
26135 | SERBP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.15e-04 | 5.89e-01 | -0.0842 |
26135 | SERBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.49e-09 | 6.62e-01 | 0.096 |
26135 | SERBP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.19e-05 | 8.94e-01 | 0.0131 |
26135 | SERBP1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.85e-03 | 6.59e-01 | -0.0177 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064029 | Cervix | CC | mRNA catabolic process | 56/2311 | 232/18723 | 4.81e-07 | 1.83e-05 | 56 |
GO:19033119 | Cervix | CC | regulation of mRNA metabolic process | 64/2311 | 288/18723 | 1.71e-06 | 5.64e-05 | 64 |
GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
GO:00610139 | Cervix | CC | regulation of mRNA catabolic process | 38/2311 | 166/18723 | 1.07e-04 | 1.36e-03 | 38 |
GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
GO:00346559 | Cervix | CC | nucleobase-containing compound catabolic process | 74/2311 | 407/18723 | 3.77e-04 | 3.88e-03 | 74 |
GO:00434889 | Cervix | CC | regulation of mRNA stability | 35/2311 | 158/18723 | 3.80e-04 | 3.89e-03 | 35 |
GO:00434879 | Cervix | CC | regulation of RNA stability | 36/2311 | 170/18723 | 7.72e-04 | 6.86e-03 | 36 |
GO:00442709 | Cervix | CC | cellular nitrogen compound catabolic process | 79/2311 | 451/18723 | 7.80e-04 | 6.91e-03 | 79 |
GO:00194398 | Cervix | CC | aromatic compound catabolic process | 79/2311 | 467/18723 | 2.14e-03 | 1.54e-02 | 79 |
GO:19013618 | Cervix | CC | organic cyclic compound catabolic process | 80/2311 | 495/18723 | 6.77e-03 | 3.72e-02 | 80 |
GO:000640214 | Cervix | N_HPV | mRNA catabolic process | 17/534 | 232/18723 | 3.76e-04 | 5.43e-03 | 17 |
GO:190331114 | Cervix | N_HPV | regulation of mRNA metabolic process | 18/534 | 288/18723 | 1.63e-03 | 1.68e-02 | 18 |
GO:000640114 | Cervix | N_HPV | RNA catabolic process | 17/534 | 278/18723 | 2.72e-03 | 2.39e-02 | 17 |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0006402 | Colorectum | AD | mRNA catabolic process | 87/3918 | 232/18723 | 4.40e-09 | 2.84e-07 | 87 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERBP1 | SNV | Missense_Mutation | novel | c.700T>C | p.Ser234Pro | p.S234P | Q8NC51 | protein_coding | tolerated_low_confidence(0.23) | benign(0.151) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SERBP1 | SNV | Missense_Mutation | rs763463886 | c.1068N>T | p.Glu356Asp | p.E356D | Q8NC51 | protein_coding | tolerated(0.19) | benign(0.061) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |