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Gene: SCN11A |
Gene summary for SCN11A |
Gene summary. |
Gene information | Species | Human | Gene symbol | SCN11A | Gene ID | 11280 |
Gene name | sodium voltage-gated channel alpha subunit 11 | |
Gene Alias | FEPS3 | |
Cytomap | 3p22.2 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | Q9UI33 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11280 | SCN11A | HCC1 | Human | Liver | HCC | 3.08e-17 | 1.59e+00 | 0.5336 |
11280 | SCN11A | HCC2 | Human | Liver | HCC | 7.99e-32 | 2.19e+00 | 0.5341 |
11280 | SCN11A | HCC5 | Human | Liver | HCC | 1.97e-27 | 1.88e+00 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCN11A | SNV | Missense_Mutation | rs564668486 | c.4978N>A | p.Ala1660Thr | p.A1660T | Q9UI33 | protein_coding | deleterious(0) | benign(0.34) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SCN11A | SNV | Missense_Mutation | c.4184N>C | p.Lys1395Thr | p.K1395T | Q9UI33 | protein_coding | tolerated(0.95) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SCN11A | SNV | Missense_Mutation | rs748885752 | c.5062G>A | p.Ala1688Thr | p.A1688T | Q9UI33 | protein_coding | deleterious(0) | possibly_damaging(0.554) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SCN11A | SNV | Missense_Mutation | rs748885752 | c.5062N>A | p.Ala1688Thr | p.A1688T | Q9UI33 | protein_coding | deleterious(0) | possibly_damaging(0.554) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
SCN11A | SNV | Missense_Mutation | rs201421435 | c.1696G>A | p.Val566Ile | p.V566I | Q9UI33 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A01Z-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SCN11A | SNV | Missense_Mutation | c.50N>A | p.Arg17His | p.R17H | Q9UI33 | protein_coding | tolerated(0.06) | benign(0.019) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCN11A | SNV | Missense_Mutation | c.856N>T | p.Arg286Trp | p.R286W | Q9UI33 | protein_coding | tolerated(0.24) | benign(0.312) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SCN11A | SNV | Missense_Mutation | rs745559210 | c.3587N>A | p.Gly1196Glu | p.G1196E | Q9UI33 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SCN11A | SNV | Missense_Mutation | rs374311646 | c.4478N>T | p.Ser1493Leu | p.S1493L | Q9UI33 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SCN11A | SNV | Missense_Mutation | novel | c.4072N>A | p.Leu1358Ile | p.L1358I | Q9UI33 | protein_coding | tolerated(0.11) | benign(0.076) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL3545209 | NKTR-171 | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL918 | PHENACEMIDE | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL1200341 | INDECAINIDE HYDROCHLORIDE | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL1201754 | RUFINAMIDE | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | Tolperisone | TOLPERISONE | ||
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL1201022 | PHENAZOPYRIDINE HYDROCHLORIDE | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL1194 | PRILOCAINE | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL919 | FOSPHENYTOIN SODIUM | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | blocker | CHEMBL1200440 | MEPIVACAINE HYDROCHLORIDE | |
11280 | SCN11A | DRUGGABLE GENOME, ION CHANNEL, KINASE | Lidocaine | LIDOCAINE |
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