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Gene: RPRD2 |
Gene summary for RPRD2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RPRD2 | Gene ID | 23248 |
| Gene name | regulation of nuclear pre-mRNA domain containing 2 | |
| Gene Alias | HSPC099 | |
| Cytomap | 1q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5VT52 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23248 | RPRD2 | CCI_1 | Human | Cervix | CC | 1.53e-14 | 1.39e+00 | 0.528 |
| 23248 | RPRD2 | CCI_2 | Human | Cervix | CC | 2.78e-09 | 9.94e-01 | 0.5249 |
| 23248 | RPRD2 | CCI_3 | Human | Cervix | CC | 4.42e-14 | 9.58e-01 | 0.516 |
| 23248 | RPRD2 | A001-C-207 | Human | Colorectum | FAP | 5.75e-03 | -2.10e-01 | 0.1278 |
| 23248 | RPRD2 | A015-C-203 | Human | Colorectum | FAP | 4.35e-26 | -3.97e-01 | -0.1294 |
| 23248 | RPRD2 | A015-C-204 | Human | Colorectum | FAP | 6.27e-06 | -2.87e-01 | -0.0228 |
| 23248 | RPRD2 | A014-C-040 | Human | Colorectum | FAP | 5.82e-04 | -3.79e-01 | -0.1184 |
| 23248 | RPRD2 | A002-C-201 | Human | Colorectum | FAP | 1.32e-13 | -3.92e-01 | 0.0324 |
| 23248 | RPRD2 | A002-C-203 | Human | Colorectum | FAP | 9.63e-03 | -1.40e-01 | 0.2786 |
| 23248 | RPRD2 | A001-C-108 | Human | Colorectum | FAP | 2.38e-14 | -2.78e-01 | -0.0272 |
| 23248 | RPRD2 | A002-C-205 | Human | Colorectum | FAP | 7.55e-21 | -4.56e-01 | -0.1236 |
| 23248 | RPRD2 | A001-C-104 | Human | Colorectum | FAP | 2.01e-03 | -2.25e-01 | 0.0184 |
| 23248 | RPRD2 | A015-C-005 | Human | Colorectum | FAP | 4.51e-03 | -2.10e-01 | -0.0336 |
| 23248 | RPRD2 | A015-C-006 | Human | Colorectum | FAP | 1.28e-14 | -5.44e-01 | -0.0994 |
| 23248 | RPRD2 | A015-C-106 | Human | Colorectum | FAP | 7.32e-09 | -2.84e-01 | -0.0511 |
| 23248 | RPRD2 | A002-C-114 | Human | Colorectum | FAP | 8.48e-16 | -3.61e-01 | -0.1561 |
| 23248 | RPRD2 | A015-C-104 | Human | Colorectum | FAP | 3.17e-28 | -4.61e-01 | -0.1899 |
| 23248 | RPRD2 | A001-C-014 | Human | Colorectum | FAP | 3.29e-17 | -3.80e-01 | 0.0135 |
| 23248 | RPRD2 | A002-C-016 | Human | Colorectum | FAP | 4.91e-23 | -3.43e-01 | 0.0521 |
| 23248 | RPRD2 | A015-C-002 | Human | Colorectum | FAP | 1.26e-12 | -4.98e-01 | -0.0763 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:003112412 | Esophagus | ESCC | mRNA 3'-end processing | 47/8552 | 62/18723 | 1.29e-06 | 1.58e-05 | 47 |
| GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
| GO:00311241 | Liver | HCC | mRNA 3'-end processing | 50/7958 | 62/18723 | 8.44e-10 | 2.60e-08 | 50 |
| GO:00311231 | Liver | HCC | RNA 3'-end processing | 81/7958 | 116/18723 | 2.27e-09 | 6.32e-08 | 81 |
| GO:00311242 | Oral cavity | OSCC | mRNA 3'-end processing | 49/7305 | 62/18723 | 1.40e-10 | 4.14e-09 | 49 |
| GO:00311232 | Oral cavity | OSCC | RNA 3'-end processing | 75/7305 | 116/18723 | 1.93e-08 | 3.79e-07 | 75 |
| GO:00311235 | Thyroid | PTC | RNA 3'-end processing | 65/5968 | 116/18723 | 6.24e-08 | 1.30e-06 | 65 |
| GO:00311245 | Thyroid | PTC | mRNA 3'-end processing | 40/5968 | 62/18723 | 1.28e-07 | 2.48e-06 | 40 |
| GO:003112312 | Thyroid | ATC | RNA 3'-end processing | 65/6293 | 116/18723 | 5.58e-07 | 7.93e-06 | 65 |
| GO:003112413 | Thyroid | ATC | mRNA 3'-end processing | 40/6293 | 62/18723 | 6.25e-07 | 8.65e-06 | 40 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| RPRD2 | SNV | Missense_Mutation | novel | c.3940N>A | p.Glu1314Lys | p.E1314K | Q5VT52 | protein_coding | deleterious_low_confidence(0.01) | benign(0.062) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| RPRD2 | SNV | Missense_Mutation | c.367A>C | p.Ile123Leu | p.I123L | Q5VT52 | protein_coding | tolerated_low_confidence(0.08) | probably_damaging(0.956) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
| RPRD2 | SNV | Missense_Mutation | c.1942A>T | p.Ile648Phe | p.I648F | Q5VT52 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| RPRD2 | SNV | Missense_Mutation | c.3808C>T | p.Pro1270Ser | p.P1270S | Q5VT52 | protein_coding | deleterious_low_confidence(0.01) | benign(0.243) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| RPRD2 | SNV | Missense_Mutation | c.4076G>T | p.Gly1359Val | p.G1359V | Q5VT52 | protein_coding | deleterious_low_confidence(0) | benign(0.015) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| RPRD2 | SNV | Missense_Mutation | novel | c.115G>A | p.Glu39Lys | p.E39K | Q5VT52 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.76) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RPRD2 | SNV | Missense_Mutation | novel | c.2137N>G | p.Thr713Ala | p.T713A | Q5VT52 | protein_coding | tolerated_low_confidence(0.07) | benign(0.003) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
| RPRD2 | SNV | Missense_Mutation | novel | c.1959N>T | p.Glu653Asp | p.E653D | Q5VT52 | protein_coding | tolerated_low_confidence(0.07) | benign(0.003) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| RPRD2 | SNV | Missense_Mutation | rs764057013 | c.3544N>T | p.Arg1182Cys | p.R1182C | Q5VT52 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.985) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| RPRD2 | SNV | Missense_Mutation | c.344N>A | p.Ser115Tyr | p.S115Y | Q5VT52 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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