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Gene: RIOK2 |
Gene summary for RIOK2 |
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Gene information | Species | Human | Gene symbol | RIOK2 | Gene ID | 55781 |
Gene name | RIO kinase 2 | |
Gene Alias | RIO2 | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0000054 | UniProtAcc | Q9BVS4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55781 | RIOK2 | LZE4T | Human | Esophagus | ESCC | 3.71e-06 | 1.76e-01 | 0.0811 |
55781 | RIOK2 | LZE24T | Human | Esophagus | ESCC | 1.20e-07 | 1.90e-01 | 0.0596 |
55781 | RIOK2 | P2T-E | Human | Esophagus | ESCC | 1.89e-11 | 2.28e-01 | 0.1177 |
55781 | RIOK2 | P4T-E | Human | Esophagus | ESCC | 2.86e-09 | 2.48e-01 | 0.1323 |
55781 | RIOK2 | P5T-E | Human | Esophagus | ESCC | 3.03e-10 | 2.26e-01 | 0.1327 |
55781 | RIOK2 | P8T-E | Human | Esophagus | ESCC | 8.57e-03 | 6.39e-02 | 0.0889 |
55781 | RIOK2 | P9T-E | Human | Esophagus | ESCC | 1.45e-02 | 5.92e-02 | 0.1131 |
55781 | RIOK2 | P10T-E | Human | Esophagus | ESCC | 1.10e-03 | 1.05e-01 | 0.116 |
55781 | RIOK2 | P12T-E | Human | Esophagus | ESCC | 5.70e-15 | 3.59e-01 | 0.1122 |
55781 | RIOK2 | P15T-E | Human | Esophagus | ESCC | 2.28e-13 | 2.65e-01 | 0.1149 |
55781 | RIOK2 | P16T-E | Human | Esophagus | ESCC | 2.55e-10 | 7.55e-02 | 0.1153 |
55781 | RIOK2 | P20T-E | Human | Esophagus | ESCC | 4.41e-14 | 2.91e-01 | 0.1124 |
55781 | RIOK2 | P21T-E | Human | Esophagus | ESCC | 1.73e-06 | 1.96e-01 | 0.1617 |
55781 | RIOK2 | P22T-E | Human | Esophagus | ESCC | 5.07e-17 | 2.95e-01 | 0.1236 |
55781 | RIOK2 | P23T-E | Human | Esophagus | ESCC | 1.39e-14 | 3.00e-01 | 0.108 |
55781 | RIOK2 | P24T-E | Human | Esophagus | ESCC | 4.08e-12 | 2.38e-01 | 0.1287 |
55781 | RIOK2 | P26T-E | Human | Esophagus | ESCC | 1.13e-19 | 3.33e-01 | 0.1276 |
55781 | RIOK2 | P27T-E | Human | Esophagus | ESCC | 9.08e-09 | 1.53e-01 | 0.1055 |
55781 | RIOK2 | P30T-E | Human | Esophagus | ESCC | 3.43e-05 | 2.00e-01 | 0.137 |
55781 | RIOK2 | P31T-E | Human | Esophagus | ESCC | 3.39e-08 | 1.13e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIOK2 | deletion | Frame_Shift_Del | novel | c.453_456delNNNN | p.Ser154ValfsTer5 | p.S154Vfs*5 | Q9BVS4 | protein_coding | TCGA-UF-A719-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
RIOK2 | SNV | Missense_Mutation | c.1556G>A | p.Arg519His | p.R519H | Q9BVS4 | protein_coding | deleterious(0.03) | possibly_damaging(0.874) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RIOK2 | SNV | Missense_Mutation | novel | c.812N>T | p.Asp271Val | p.D271V | Q9BVS4 | protein_coding | deleterious(0.04) | benign(0.043) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
RIOK2 | SNV | Missense_Mutation | c.1495N>A | p.Glu499Lys | p.E499K | Q9BVS4 | protein_coding | deleterious(0.03) | benign(0.287) | TCGA-DE-A0Y2-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RIOK2 | SNV | Missense_Mutation | rs200897705 | c.1004C>T | p.Ser335Leu | p.S335L | Q9BVS4 | protein_coding | tolerated(0.19) | benign(0.001) | TCGA-EL-A4KG-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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