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Gene: RHPN2 |
Gene summary for RHPN2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RHPN2 | Gene ID | 85415 |
Gene name | rhophilin Rho GTPase binding protein 2 | |
Gene Alias | P76RBE | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8IUC4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85415 | RHPN2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.11e-03 | 1.01e+00 | -0.2602 |
85415 | RHPN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.00e-02 | 4.41e-01 | -0.1464 |
85415 | RHPN2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.44e-04 | 6.07e-01 | -0.059 |
85415 | RHPN2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.02e-04 | 5.65e-01 | -0.0842 |
85415 | RHPN2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.03e-02 | 8.52e-01 | 0.3487 |
85415 | RHPN2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.31e-08 | 7.21e-01 | 0.281 |
85415 | RHPN2 | A015-C-203 | Human | Colorectum | FAP | 6.52e-17 | -1.67e-01 | -0.1294 |
85415 | RHPN2 | A002-C-201 | Human | Colorectum | FAP | 1.71e-05 | -9.53e-02 | 0.0324 |
85415 | RHPN2 | A001-C-119 | Human | Colorectum | FAP | 2.01e-05 | 2.68e-01 | -0.1557 |
85415 | RHPN2 | A001-C-108 | Human | Colorectum | FAP | 5.52e-10 | -1.25e-01 | -0.0272 |
85415 | RHPN2 | A002-C-205 | Human | Colorectum | FAP | 8.16e-14 | -1.68e-03 | -0.1236 |
85415 | RHPN2 | A015-C-005 | Human | Colorectum | FAP | 7.27e-13 | 5.79e-01 | -0.0336 |
85415 | RHPN2 | A015-C-006 | Human | Colorectum | FAP | 7.62e-08 | -1.07e-01 | -0.0994 |
85415 | RHPN2 | A015-C-106 | Human | Colorectum | FAP | 2.05e-04 | 2.11e-02 | -0.0511 |
85415 | RHPN2 | A002-C-114 | Human | Colorectum | FAP | 7.28e-12 | 2.14e-02 | -0.1561 |
85415 | RHPN2 | A015-C-104 | Human | Colorectum | FAP | 1.62e-21 | -1.14e-01 | -0.1899 |
85415 | RHPN2 | A001-C-014 | Human | Colorectum | FAP | 9.86e-09 | -1.20e-01 | 0.0135 |
85415 | RHPN2 | A002-C-016 | Human | Colorectum | FAP | 2.37e-16 | -1.46e-01 | 0.0521 |
85415 | RHPN2 | A015-C-002 | Human | Colorectum | FAP | 5.50e-07 | -2.82e-02 | -0.0763 |
85415 | RHPN2 | A001-C-203 | Human | Colorectum | FAP | 1.64e-06 | -2.15e-02 | -0.0481 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0061572 | Colorectum | AD | actin filament bundle organization | 60/3918 | 161/18723 | 1.33e-06 | 4.23e-05 | 60 |
GO:0051017 | Colorectum | AD | actin filament bundle assembly | 58/3918 | 157/18723 | 2.74e-06 | 7.89e-05 | 58 |
GO:1902904 | Colorectum | AD | negative regulation of supramolecular fiber organization | 60/3918 | 167/18723 | 5.23e-06 | 1.35e-04 | 60 |
GO:0051494 | Colorectum | AD | negative regulation of cytoskeleton organization | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
GO:0031032 | Colorectum | AD | actomyosin structure organization | 65/3918 | 196/18723 | 4.17e-05 | 7.37e-04 | 65 |
GO:0030038 | Colorectum | AD | contractile actin filament bundle assembly | 39/3918 | 106/18723 | 1.22e-04 | 1.78e-03 | 39 |
GO:0043149 | Colorectum | AD | stress fiber assembly | 39/3918 | 106/18723 | 1.22e-04 | 1.78e-03 | 39 |
GO:0032231 | Colorectum | AD | regulation of actin filament bundle assembly | 37/3918 | 105/18723 | 4.82e-04 | 5.27e-03 | 37 |
GO:0110020 | Colorectum | AD | regulation of actomyosin structure organization | 35/3918 | 100/18723 | 7.78e-04 | 7.78e-03 | 35 |
GO:0051492 | Colorectum | AD | regulation of stress fiber assembly | 32/3918 | 91/18723 | 1.17e-03 | 1.05e-02 | 32 |
GO:0003014 | Colorectum | AD | renal system process | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:00070151 | Colorectum | SER | actin filament organization | 134/2897 | 442/18723 | 1.39e-15 | 5.70e-13 | 134 |
GO:01100531 | Colorectum | SER | regulation of actin filament organization | 91/2897 | 278/18723 | 4.33e-13 | 1.40e-10 | 91 |
GO:19029031 | Colorectum | SER | regulation of supramolecular fiber organization | 114/2897 | 383/18723 | 7.32e-13 | 1.95e-10 | 114 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHPN2 | SNV | Missense_Mutation | c.270G>C | p.Glu90Asp | p.E90D | Q8IUC4 | protein_coding | deleterious(0.01) | benign(0.052) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RHPN2 | SNV | Missense_Mutation | rs760951199 | c.1405G>A | p.Ala469Thr | p.A469T | Q8IUC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.834) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
RHPN2 | SNV | Missense_Mutation | novel | c.2042C>T | p.Ser681Leu | p.S681L | Q8IUC4 | protein_coding | deleterious_low_confidence(0.01) | benign(0.05) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
RHPN2 | SNV | Missense_Mutation | rs752325119 | c.382N>A | p.Val128Ile | p.V128I | Q8IUC4 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-UP-A6WW-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RHPN2 | SNV | Missense_Mutation | c.661N>C | p.Phe221Leu | p.F221L | Q8IUC4 | protein_coding | deleterious(0.04) | benign(0.059) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RHPN2 | SNV | Missense_Mutation | c.343N>G | p.Leu115Val | p.L115V | Q8IUC4 | protein_coding | deleterious(0.03) | benign(0.37) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RHPN2 | SNV | Missense_Mutation | rs753950362 | c.1600G>A | p.Ala534Thr | p.A534T | Q8IUC4 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHPN2 | SNV | Missense_Mutation | c.957G>C | p.Glu319Asp | p.E319D | Q8IUC4 | protein_coding | tolerated(0.47) | possibly_damaging(0.676) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHPN2 | SNV | Missense_Mutation | novel | c.1385A>C | p.Asp462Ala | p.D462A | Q8IUC4 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-CD-A48A-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | capecitabine | CR |
RHPN2 | SNV | Missense_Mutation | c.1931G>A | p.Gly644Asp | p.G644D | Q8IUC4 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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