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Gene: RAI1 |
Gene summary for RAI1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RAI1 | Gene ID | 10743 |
Gene name | retinoic acid induced 1 | |
Gene Alias | SMCR | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q7Z5J4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10743 | RAI1 | CCI_1 | Human | Cervix | CC | 2.94e-05 | 7.50e-01 | 0.528 |
10743 | RAI1 | CCI_2 | Human | Cervix | CC | 7.34e-10 | 1.05e+00 | 0.5249 |
10743 | RAI1 | CCI_3 | Human | Cervix | CC | 2.17e-06 | 6.29e-01 | 0.516 |
10743 | RAI1 | LZE2T | Human | Esophagus | ESCC | 4.78e-02 | 4.22e-01 | 0.082 |
10743 | RAI1 | LZE24T | Human | Esophagus | ESCC | 8.64e-07 | 1.39e-01 | 0.0596 |
10743 | RAI1 | LZE21T | Human | Esophagus | ESCC | 4.41e-06 | 1.82e-01 | 0.0655 |
10743 | RAI1 | P1T-E | Human | Esophagus | ESCC | 2.65e-05 | 1.20e-01 | 0.0875 |
10743 | RAI1 | P2T-E | Human | Esophagus | ESCC | 2.31e-10 | 9.17e-02 | 0.1177 |
10743 | RAI1 | P4T-E | Human | Esophagus | ESCC | 1.37e-08 | 1.52e-01 | 0.1323 |
10743 | RAI1 | P8T-E | Human | Esophagus | ESCC | 3.79e-15 | 2.35e-01 | 0.0889 |
10743 | RAI1 | P9T-E | Human | Esophagus | ESCC | 1.38e-06 | 1.07e-01 | 0.1131 |
10743 | RAI1 | P10T-E | Human | Esophagus | ESCC | 7.10e-18 | 1.96e-01 | 0.116 |
10743 | RAI1 | P11T-E | Human | Esophagus | ESCC | 7.23e-07 | 6.77e-02 | 0.1426 |
10743 | RAI1 | P12T-E | Human | Esophagus | ESCC | 4.15e-09 | 7.09e-02 | 0.1122 |
10743 | RAI1 | P15T-E | Human | Esophagus | ESCC | 2.43e-11 | 1.34e-01 | 0.1149 |
10743 | RAI1 | P16T-E | Human | Esophagus | ESCC | 1.00e-05 | 3.18e-02 | 0.1153 |
10743 | RAI1 | P17T-E | Human | Esophagus | ESCC | 3.83e-05 | 5.04e-02 | 0.1278 |
10743 | RAI1 | P20T-E | Human | Esophagus | ESCC | 1.10e-12 | 6.84e-02 | 0.1124 |
10743 | RAI1 | P21T-E | Human | Esophagus | ESCC | 1.86e-10 | 1.12e-01 | 0.1617 |
10743 | RAI1 | P22T-E | Human | Esophagus | ESCC | 1.63e-15 | 1.09e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:00076238 | Cervix | CC | circadian rhythm | 46/2311 | 210/18723 | 6.76e-05 | 9.60e-04 | 46 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00329226 | Cervix | CC | circadian regulation of gene expression | 18/2311 | 68/18723 | 1.18e-03 | 9.56e-03 | 18 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0061180 | Colorectum | AD | mammary gland epithelium development | 28/3918 | 67/18723 | 8.74e-05 | 1.35e-03 | 28 |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00611801 | Colorectum | SER | mammary gland epithelium development | 22/2897 | 67/18723 | 3.11e-04 | 5.03e-03 | 22 |
GO:00308791 | Colorectum | SER | mammary gland development | 37/2897 | 137/18723 | 3.61e-04 | 5.61e-03 | 37 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00611802 | Colorectum | MSS | mammary gland epithelium development | 28/3467 | 67/18723 | 8.47e-06 | 2.11e-04 | 28 |
GO:0051349 | Colorectum | MSS | positive regulation of lyase activity | 10/3467 | 23/18723 | 5.06e-03 | 3.47e-02 | 10 |
GO:00487323 | Colorectum | MSI-H | gland development | 53/1319 | 436/18723 | 7.08e-05 | 2.35e-03 | 53 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:003292215 | Esophagus | ESCC | circadian regulation of gene expression | 48/8552 | 68/18723 | 2.76e-05 | 2.30e-04 | 48 |
GO:003087914 | Esophagus | ESCC | mammary gland development | 85/8552 | 137/18723 | 8.11e-05 | 6.01e-04 | 85 |
GO:00352647 | Esophagus | ESCC | multicellular organism growth | 80/8552 | 132/18723 | 3.84e-04 | 2.22e-03 | 80 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAI1 | SNV | Missense_Mutation | novel | c.4256N>A | p.Ser1419Tyr | p.S1419Y | Q7Z5J4 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | rs747782128 | c.1138N>A | p.Gly380Arg | p.G380R | Q7Z5J4 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | rs750604586 | c.1607G>A | p.Arg536His | p.R536H | Q7Z5J4 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
RAI1 | SNV | Missense_Mutation | novel | c.1997N>T | p.Ala666Val | p.A666V | Q7Z5J4 | protein_coding | tolerated(0.08) | benign(0.024) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | novel | c.3976N>T | p.Gly1326Cys | p.G1326C | Q7Z5J4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | novel | c.1690A>G | p.Met564Val | p.M564V | Q7Z5J4 | protein_coding | tolerated(0.06) | probably_damaging(0.914) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | novel | c.2752T>C | p.Cys918Arg | p.C918R | Q7Z5J4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.648) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RAI1 | SNV | Missense_Mutation | novel | c.922N>A | p.Leu308Ile | p.L308I | Q7Z5J4 | protein_coding | deleterious(0.02) | benign(0.158) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | novel | c.1322N>G | p.Gln441Arg | p.Q441R | Q7Z5J4 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAI1 | SNV | Missense_Mutation | novel | c.4327N>T | p.Ala1443Ser | p.A1443S | Q7Z5J4 | protein_coding | tolerated(0.33) | benign(0.214) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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