![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: QARS |
Gene summary for QARS |
![]() |
Gene information | Species | Human | Gene symbol | QARS | Gene ID | 5859 |
Gene name | glutaminyl-tRNA synthetase 1 | |
Gene Alias | GLNRS | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | B7Z840 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5859 | QARS | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.24e-45 | 9.16e-01 | 0.294 |
5859 | QARS | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.28e-12 | 1.65e+00 | 0.3487 |
5859 | QARS | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.46e-35 | 1.36e+00 | 0.281 |
5859 | QARS | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.98e-95 | 1.94e+00 | 0.3859 |
5859 | QARS | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.00e-23 | 1.01e+00 | 0.2585 |
5859 | QARS | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.12e-51 | 1.10e+00 | 0.3005 |
5859 | QARS | LZE2T | Human | Esophagus | ESCC | 1.39e-04 | 1.70e-01 | 0.082 |
5859 | QARS | LZE4T | Human | Esophagus | ESCC | 1.45e-07 | -1.81e-02 | 0.0811 |
5859 | QARS | LZE5T | Human | Esophagus | ESCC | 7.39e-07 | 4.45e-02 | 0.0514 |
5859 | QARS | LZE7T | Human | Esophagus | ESCC | 8.55e-09 | 8.61e-02 | 0.0667 |
5859 | QARS | LZE8T | Human | Esophagus | ESCC | 6.35e-08 | -1.11e-01 | 0.067 |
5859 | QARS | LZE20T | Human | Esophagus | ESCC | 1.80e-06 | -1.69e-01 | 0.0662 |
5859 | QARS | LZE22D1 | Human | Esophagus | HGIN | 3.68e-06 | -7.08e-02 | 0.0595 |
5859 | QARS | LZE24T | Human | Esophagus | ESCC | 7.47e-16 | 1.62e-01 | 0.0596 |
5859 | QARS | LZE6T | Human | Esophagus | ESCC | 2.09e-04 | -1.09e-01 | 0.0845 |
5859 | QARS | P1T-E | Human | Esophagus | ESCC | 3.62e-05 | 1.96e-01 | 0.0875 |
5859 | QARS | P2T-E | Human | Esophagus | ESCC | 3.47e-33 | 2.65e-01 | 0.1177 |
5859 | QARS | P4T-E | Human | Esophagus | ESCC | 1.62e-15 | 2.99e-01 | 0.1323 |
5859 | QARS | P5T-E | Human | Esophagus | ESCC | 3.09e-13 | -1.04e-01 | 0.1327 |
5859 | QARS | P8T-E | Human | Esophagus | ESCC | 1.23e-10 | 1.80e-01 | 0.0889 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0001933 | Colorectum | AD | negative regulation of protein phosphorylation | 101/3918 | 342/18723 | 9.39e-05 | 1.42e-03 | 101 |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043409 | Colorectum | AD | negative regulation of MAPK cascade | 57/3918 | 180/18723 | 4.61e-04 | 5.14e-03 | 57 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0006469 | Colorectum | AD | negative regulation of protein kinase activity | 65/3918 | 212/18723 | 5.21e-04 | 5.62e-03 | 65 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:0070302 | Colorectum | AD | regulation of stress-activated protein kinase signaling cascade | 58/3918 | 195/18723 | 2.21e-03 | 1.74e-02 | 58 |
GO:0032872 | Colorectum | AD | regulation of stress-activated MAPK cascade | 57/3918 | 192/18723 | 2.51e-03 | 1.92e-02 | 57 |
GO:0032873 | Colorectum | AD | negative regulation of stress-activated MAPK cascade | 19/3918 | 51/18723 | 5.44e-03 | 3.55e-02 | 19 |
GO:0070303 | Colorectum | AD | negative regulation of stress-activated protein kinase signaling cascade | 19/3918 | 51/18723 | 5.44e-03 | 3.55e-02 | 19 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
QARS | SNV | Missense_Mutation | novel | c.860A>G | p.Asn287Ser | p.N287S | P47897 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-98-8023-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
QARS | SNV | Missense_Mutation | novel | c.1394N>G | p.Ser465Cys | p.S465C | P47897 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BA-A4IF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
QARS | SNV | Missense_Mutation | novel | c.1813N>G | p.Gln605Glu | p.Q605E | P47897 | protein_coding | tolerated(0.4) | benign(0.034) | TCGA-CR-6481-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
QARS | SNV | Missense_Mutation | novel | c.850N>G | p.Ile284Val | p.I284V | P47897 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-A6JN-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
QARS | SNV | Missense_Mutation | novel | c.572T>C | p.Val191Ala | p.V191A | P47897 | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
QARS | SNV | Missense_Mutation | c.493N>G | p.Ile165Val | p.I165V | P47897 | protein_coding | tolerated(1) | benign(0.015) | TCGA-EJ-7792-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
QARS | SNV | Missense_Mutation | c.560A>G | p.Lys187Arg | p.K187R | P47897 | protein_coding | tolerated(0.06) | benign(0.036) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
QARS | SNV | Missense_Mutation | c.1223T>C | p.Met408Thr | p.M408T | P47897 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
QARS | SNV | Missense_Mutation | novel | c.875A>C | p.Lys292Thr | p.K292T | P47897 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-BR-8060-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
QARS | SNV | Missense_Mutation | novel | c.1055N>A | p.Arg352Lys | p.R352K | P47897 | protein_coding | tolerated(0.7) | benign(0.04) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |