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Gene: PWWP2A |
Gene summary for PWWP2A |
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Gene information | Species | Human | Gene symbol | PWWP2A | Gene ID | 114825 |
Gene name | PWWP domain containing 2A | |
Gene Alias | MST101 | |
Cytomap | 5q33.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96N64 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114825 | PWWP2A | LZE20T | Human | Esophagus | ESCC | 1.59e-02 | 1.38e-01 | 0.0662 |
114825 | PWWP2A | LZE24T | Human | Esophagus | ESCC | 3.42e-06 | 1.95e-01 | 0.0596 |
114825 | PWWP2A | P1T-E | Human | Esophagus | ESCC | 9.95e-13 | 4.58e-01 | 0.0875 |
114825 | PWWP2A | P2T-E | Human | Esophagus | ESCC | 7.23e-34 | 6.18e-01 | 0.1177 |
114825 | PWWP2A | P4T-E | Human | Esophagus | ESCC | 1.71e-20 | 4.06e-01 | 0.1323 |
114825 | PWWP2A | P5T-E | Human | Esophagus | ESCC | 1.76e-17 | 2.88e-01 | 0.1327 |
114825 | PWWP2A | P8T-E | Human | Esophagus | ESCC | 6.95e-08 | 1.51e-01 | 0.0889 |
114825 | PWWP2A | P9T-E | Human | Esophagus | ESCC | 4.54e-08 | 1.71e-01 | 0.1131 |
114825 | PWWP2A | P10T-E | Human | Esophagus | ESCC | 1.27e-13 | 1.91e-01 | 0.116 |
114825 | PWWP2A | P11T-E | Human | Esophagus | ESCC | 7.34e-12 | 6.26e-01 | 0.1426 |
114825 | PWWP2A | P12T-E | Human | Esophagus | ESCC | 9.59e-25 | 4.09e-01 | 0.1122 |
114825 | PWWP2A | P15T-E | Human | Esophagus | ESCC | 2.47e-17 | 3.39e-01 | 0.1149 |
114825 | PWWP2A | P16T-E | Human | Esophagus | ESCC | 1.25e-20 | 2.72e-01 | 0.1153 |
114825 | PWWP2A | P17T-E | Human | Esophagus | ESCC | 2.13e-05 | 2.92e-01 | 0.1278 |
114825 | PWWP2A | P19T-E | Human | Esophagus | ESCC | 8.91e-05 | 3.68e-01 | 0.1662 |
114825 | PWWP2A | P20T-E | Human | Esophagus | ESCC | 2.06e-16 | 2.82e-01 | 0.1124 |
114825 | PWWP2A | P21T-E | Human | Esophagus | ESCC | 1.84e-13 | 2.17e-01 | 0.1617 |
114825 | PWWP2A | P22T-E | Human | Esophagus | ESCC | 4.85e-12 | 1.96e-01 | 0.1236 |
114825 | PWWP2A | P23T-E | Human | Esophagus | ESCC | 1.57e-18 | 3.94e-01 | 0.108 |
114825 | PWWP2A | P24T-E | Human | Esophagus | ESCC | 1.16e-07 | 1.61e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PWWP2A | SNV | Missense_Mutation | c.2233N>A | p.Glu745Lys | p.E745K | Q96N64 | protein_coding | deleterious(0) | possibly_damaging(0.739) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PWWP2A | SNV | Missense_Mutation | novel | c.2182N>C | p.Tyr728His | p.Y728H | Q96N64 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PWWP2A | SNV | Missense_Mutation | c.2075N>A | p.Arg692His | p.R692H | Q96N64 | protein_coding | deleterious(0.03) | possibly_damaging(0.786) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PWWP2A | SNV | Missense_Mutation | novel | c.1010G>T | p.Arg337Ile | p.R337I | Q96N64 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PWWP2A | SNV | Missense_Mutation | novel | c.1878N>T | p.Glu626Asp | p.E626D | Q96N64 | protein_coding | tolerated(0.25) | benign(0.039) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
PWWP2A | SNV | Missense_Mutation | rs760451010 | c.989T>C | p.Val330Ala | p.V330A | Q96N64 | protein_coding | tolerated(0.43) | benign(0.021) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PWWP2A | SNV | Missense_Mutation | c.896N>A | p.Arg299Gln | p.R299Q | Q96N64 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PWWP2A | SNV | Missense_Mutation | novel | c.1751N>A | p.Ser584Asn | p.S584N | Q96N64 | protein_coding | deleterious(0) | benign(0.052) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PWWP2A | deletion | Frame_Shift_Del | c.1001delN | p.Lys334ArgfsTer25 | p.K334Rfs*25 | Q96N64 | protein_coding | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |||
PWWP2A | deletion | Frame_Shift_Del | novel | c.1685delN | p.Asn562ThrfsTer7 | p.N562Tfs*7 | Q96N64 | protein_coding | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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