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Gene: PPP1R12C |
Gene summary for PPP1R12C |
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Gene information | Species | Human | Gene symbol | PPP1R12C | Gene ID | 54776 |
Gene name | protein phosphatase 1 regulatory subunit 12C | |
Gene Alias | AAVS1 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BZL4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54776 | PPP1R12C | HCC1_Meng | Human | Liver | HCC | 9.14e-17 | -5.87e-03 | 0.0246 |
54776 | PPP1R12C | HCC2_Meng | Human | Liver | HCC | 5.99e-12 | 1.16e-01 | 0.0107 |
54776 | PPP1R12C | HCC1 | Human | Liver | HCC | 5.31e-12 | 3.62e+00 | 0.5336 |
54776 | PPP1R12C | HCC2 | Human | Liver | HCC | 9.96e-21 | 3.07e+00 | 0.5341 |
54776 | PPP1R12C | HCC5 | Human | Liver | HCC | 6.07e-03 | 1.65e+00 | 0.4932 |
54776 | PPP1R12C | S014 | Human | Liver | HCC | 2.46e-06 | 2.20e-01 | 0.2254 |
54776 | PPP1R12C | S015 | Human | Liver | HCC | 3.05e-05 | 2.63e-01 | 0.2375 |
54776 | PPP1R12C | S016 | Human | Liver | HCC | 6.63e-07 | 2.31e-01 | 0.2243 |
54776 | PPP1R12C | S027 | Human | Liver | HCC | 5.11e-09 | 5.16e-01 | 0.2446 |
54776 | PPP1R12C | S028 | Human | Liver | HCC | 6.66e-17 | 4.97e-01 | 0.2503 |
54776 | PPP1R12C | S029 | Human | Liver | HCC | 9.64e-16 | 5.22e-01 | 0.2581 |
54776 | PPP1R12C | male-WTA | Human | Thyroid | PTC | 1.42e-14 | 1.86e-01 | 0.1037 |
54776 | PPP1R12C | PTC04 | Human | Thyroid | PTC | 7.20e-18 | 3.23e-01 | 0.1927 |
54776 | PPP1R12C | PTC05 | Human | Thyroid | PTC | 1.62e-12 | 3.90e-01 | 0.2065 |
54776 | PPP1R12C | PTC06 | Human | Thyroid | PTC | 1.74e-15 | 3.98e-01 | 0.2057 |
54776 | PPP1R12C | PTC07 | Human | Thyroid | PTC | 1.49e-12 | 2.36e-01 | 0.2044 |
54776 | PPP1R12C | ATC11 | Human | Thyroid | ATC | 3.08e-03 | 4.35e-01 | 0.3386 |
54776 | PPP1R12C | ATC12 | Human | Thyroid | ATC | 1.30e-08 | 2.18e-01 | 0.34 |
54776 | PPP1R12C | ATC13 | Human | Thyroid | ATC | 1.20e-28 | 4.58e-01 | 0.34 |
54776 | PPP1R12C | ATC2 | Human | Thyroid | ATC | 4.80e-21 | 1.20e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0451051 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R12C | SNV | Missense_Mutation | novel | c.1823N>A | p.Arg608Lys | p.R608K | Q9BZL4 | protein_coding | tolerated(0.24) | benign(0.047) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPP1R12C | SNV | Missense_Mutation | c.2285N>T | p.Asp762Val | p.D762V | Q9BZL4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPP1R12C | SNV | Missense_Mutation | novel | c.1973N>T | p.Ser658Leu | p.S658L | Q9BZL4 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-68-8251-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
PPP1R12C | SNV | Missense_Mutation | novel | c.1004N>T | p.Pro335Leu | p.P335L | Q9BZL4 | protein_coding | deleterious(0.04) | benign(0.091) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP1R12C | SNV | Missense_Mutation | novel | c.1395N>T | p.Glu465Asp | p.E465D | Q9BZL4 | protein_coding | tolerated(0.09) | possibly_damaging(0.755) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PPP1R12C | SNV | Missense_Mutation | rs369559413 | c.1514C>T | p.Pro505Leu | p.P505L | Q9BZL4 | protein_coding | tolerated(0.16) | benign(0) | TCGA-CN-4739-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
PPP1R12C | SNV | Missense_Mutation | rs768010986 | c.2239G>A | p.Ala747Thr | p.A747T | Q9BZL4 | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PPP1R12C | SNV | Missense_Mutation | novel | c.1999N>A | p.Asp667Asn | p.D667N | Q9BZL4 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PPP1R12C | SNV | Missense_Mutation | c.697N>A | p.Val233Met | p.V233M | Q9BZL4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PPP1R12C | SNV | Missense_Mutation | c.955C>T | p.Arg319Trp | p.R319W | Q9BZL4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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