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Gene: POPDC3 |
Gene summary for POPDC3 |
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Gene information | Species | Human | Gene symbol | POPDC3 | Gene ID | 64208 |
Gene name | popeye domain containing 3 | |
Gene Alias | LGMDR26 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9HBV1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64208 | POPDC3 | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 1.42e-01 | 0.0811 |
64208 | POPDC3 | P5T-E | Human | Esophagus | ESCC | 5.30e-21 | 3.54e-01 | 0.1327 |
64208 | POPDC3 | P11T-E | Human | Esophagus | ESCC | 2.06e-07 | 3.76e-01 | 0.1426 |
64208 | POPDC3 | P12T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.41e-01 | 0.1122 |
64208 | POPDC3 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.74e-01 | 0.1278 |
64208 | POPDC3 | P21T-E | Human | Esophagus | ESCC | 1.75e-25 | 5.56e-01 | 0.1617 |
64208 | POPDC3 | P28T-E | Human | Esophagus | ESCC | 1.66e-02 | 9.61e-02 | 0.1149 |
64208 | POPDC3 | P30T-E | Human | Esophagus | ESCC | 4.84e-02 | 1.33e-01 | 0.137 |
64208 | POPDC3 | P32T-E | Human | Esophagus | ESCC | 5.88e-35 | 6.48e-01 | 0.1666 |
64208 | POPDC3 | P38T-E | Human | Esophagus | ESCC | 3.67e-05 | 3.05e-01 | 0.127 |
64208 | POPDC3 | P40T-E | Human | Esophagus | ESCC | 8.35e-06 | 2.80e-01 | 0.109 |
64208 | POPDC3 | P49T-E | Human | Esophagus | ESCC | 1.19e-25 | 1.60e+00 | 0.1768 |
64208 | POPDC3 | P52T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.70e-01 | 0.1555 |
64208 | POPDC3 | P62T-E | Human | Esophagus | ESCC | 2.60e-03 | 1.33e-01 | 0.1302 |
64208 | POPDC3 | P74T-E | Human | Esophagus | ESCC | 1.96e-03 | 1.60e-01 | 0.1479 |
64208 | POPDC3 | P76T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.13e-01 | 0.1207 |
64208 | POPDC3 | P79T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.31e-01 | 0.1154 |
64208 | POPDC3 | P82T-E | Human | Esophagus | ESCC | 4.14e-03 | 3.53e-01 | 0.1072 |
64208 | POPDC3 | P83T-E | Human | Esophagus | ESCC | 1.92e-39 | 9.50e-01 | 0.1738 |
64208 | POPDC3 | P89T-E | Human | Esophagus | ESCC | 6.22e-10 | 6.24e-01 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006053716 | Esophagus | ESCC | muscle tissue development | 211/8552 | 403/18723 | 3.84e-03 | 1.56e-02 | 211 |
GO:001470615 | Esophagus | ESCC | striated muscle tissue development | 197/8552 | 384/18723 | 1.46e-02 | 4.74e-02 | 197 |
GO:00605378 | Oral cavity | OSCC | muscle tissue development | 185/7305 | 403/18723 | 2.60e-03 | 1.14e-02 | 185 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:00147067 | Oral cavity | OSCC | striated muscle tissue development | 174/7305 | 384/18723 | 6.45e-03 | 2.40e-02 | 174 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POPDC3 | SNV | Missense_Mutation | c.743A>T | p.Asp248Val | p.D248V | Q9HBV1 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-66-2755-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
POPDC3 | SNV | Missense_Mutation | novel | c.636G>T | p.Trp212Cys | p.W212C | Q9HBV1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-68-7757-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
POPDC3 | SNV | Missense_Mutation | novel | c.820N>A | p.Arg274Ser | p.R274S | Q9HBV1 | protein_coding | tolerated(0.68) | benign(0) | TCGA-77-7463-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
POPDC3 | SNV | Missense_Mutation | novel | c.820N>A | p.Arg274Ser | p.R274S | Q9HBV1 | protein_coding | tolerated(0.68) | benign(0) | TCGA-94-A4VJ-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POPDC3 | SNV | Missense_Mutation | novel | c.631T>A | p.Ser211Thr | p.S211T | Q9HBV1 | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
POPDC3 | SNV | Missense_Mutation | novel | c.207N>C | p.Trp69Cys | p.W69C | Q9HBV1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-7245-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
POPDC3 | SNV | Missense_Mutation | c.758G>A | p.Gly253Glu | p.G253E | Q9HBV1 | protein_coding | tolerated(0.19) | benign(0.196) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
POPDC3 | SNV | Missense_Mutation | c.767A>G | p.Tyr256Cys | p.Y256C | Q9HBV1 | protein_coding | tolerated(0.08) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POPDC3 | SNV | Missense_Mutation | c.724A>C | p.Lys242Gln | p.K242Q | Q9HBV1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
POPDC3 | SNV | Missense_Mutation | novel | c.653N>G | p.Tyr218Cys | p.Y218C | Q9HBV1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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