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Gene: POLI |
Gene summary for POLI |
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Gene information | Species | Human | Gene symbol | POLI | Gene ID | 11201 |
Gene name | DNA polymerase iota | |
Gene Alias | RAD30B | |
Cytomap | 18q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q9UNA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11201 | POLI | Dong_P3 | Human | Prostate | Tumor | 4.04e-02 | 8.41e-02 | 0.0278 |
11201 | POLI | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 3.52e-03 | 3.76e-01 | 0.1633 |
11201 | POLI | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.47e-05 | 4.13e-01 | 0.1608 |
11201 | POLI | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 2.42e-07 | 5.33e-01 | 0.1604 |
11201 | POLI | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.66e-03 | 5.70e-01 | 0.1622 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007189714 | Prostate | Tumor | DNA biosynthetic process | 51/3246 | 180/18723 | 1.63e-04 | 1.46e-03 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLI | SNV | Missense_Mutation | novel | c.313N>C | p.Asn105His | p.N105H | Q9UNA4 | protein_coding | tolerated(0.14) | possibly_damaging(0.556) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLI | SNV | Missense_Mutation | novel | c.718C>A | p.Pro240Thr | p.P240T | Q9UNA4 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
POLI | SNV | Missense_Mutation | c.939G>T | p.Glu313Asp | p.E313D | Q9UNA4 | protein_coding | tolerated(0.21) | possibly_damaging(0.693) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
POLI | insertion | Frame_Shift_Ins | novel | c.1719_1720insA | p.Gln576ThrfsTer10 | p.Q576Tfs*10 | Q9UNA4 | protein_coding | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
POLI | SNV | Missense_Mutation | c.1118N>T | p.Arg373Leu | p.R373L | Q9UNA4 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-55-7227-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
POLI | SNV | Missense_Mutation | c.1120T>C | p.Tyr374His | p.Y374H | Q9UNA4 | protein_coding | tolerated(0.07) | benign(0.16) | TCGA-75-5146-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
POLI | SNV | Missense_Mutation | novel | c.175N>T | p.Asp59Tyr | p.D59Y | Q9UNA4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLI | SNV | Missense_Mutation | rs778771682 | c.1543A>G | p.Ile515Val | p.I515V | Q9UNA4 | protein_coding | tolerated(0.41) | benign(0.026) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
POLI | SNV | Missense_Mutation | c.1145G>T | p.Arg382Leu | p.R382L | Q9UNA4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-37-3783-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
POLI | SNV | Missense_Mutation | novel | c.349N>T | p.Val117Leu | p.V117L | Q9UNA4 | protein_coding | deleterious(0.04) | benign(0.222) | TCGA-CN-5355-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11201 | POLI | DNA REPAIR | RHEIN | RHEIN | ||
11201 | POLI | DNA REPAIR | TETRAIDOFLUORESCEIN | TETRAIDOFLUORESCEIN | ||
11201 | POLI | DNA REPAIR | (-)-DICENTRINE | CHEMBL478754 | ||
11201 | POLI | DNA REPAIR | SCLEROTIORIN | SCLEROTIORIN | ||
11201 | POLI | DNA REPAIR | 9,10-PHENANTHRENEQUINONE | 9,10-PHENANTHRENEQUINONE | ||
11201 | POLI | DNA REPAIR | FURAMIDINE | FURAMIDINE | ||
11201 | POLI | DNA REPAIR | 5,6,7,8,4'-PENTAHYDROXYFLAVONE | CHEMBL234338 | ||
11201 | POLI | DNA REPAIR | CEPHALOCHROMIN | CEPHALOCHROMIN | ||
11201 | POLI | DNA REPAIR | HOMIDIUM BROMIDE | HOMIDIUM BROMIDE | ||
11201 | POLI | DNA REPAIR | LAVENDUSTIN B | LAVENDUSTIN B |
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