![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PNMA3 |
Gene summary for PNMA3 |
![]() |
Gene information | Species | Human | Gene symbol | PNMA3 | Gene ID | 29944 |
Gene name | PNMA family member 3 | |
Gene Alias | MA3 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q9UL41 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29944 | PNMA3 | HCC1 | Human | Liver | HCC | 5.16e-13 | 2.58e+00 | 0.5336 |
29944 | PNMA3 | S014 | Human | Liver | HCC | 2.32e-12 | 3.54e-01 | 0.2254 |
29944 | PNMA3 | S015 | Human | Liver | HCC | 1.61e-18 | 6.63e-01 | 0.2375 |
29944 | PNMA3 | S016 | Human | Liver | HCC | 1.12e-11 | 3.65e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNMA3 | SNV | Missense_Mutation | novel | c.1141N>A | p.Gln381Lys | p.Q381K | Q9UL41 | protein_coding | tolerated(0.11) | benign(0.173) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PNMA3 | deletion | Frame_Shift_Del | novel | c.32delN | p.Glu13AsnfsTer3 | p.E13Nfs*3 | Q9UL41 | protein_coding | TCGA-39-5030-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
PNMA3 | insertion | Frame_Shift_Ins | novel | c.1140_1141insA | p.Gln381ThrfsTer36 | p.Q381Tfs*36 | Q9UL41 | protein_coding | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
PNMA3 | SNV | Missense_Mutation | rs782049640 | c.1228C>T | p.Arg410Cys | p.R410C | Q9UL41 | protein_coding | deleterious(0.01) | possibly_damaging(0.629) | TCGA-BA-5556-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PNMA3 | SNV | Missense_Mutation | novel | c.254N>G | p.Lys85Arg | p.K85R | Q9UL41 | protein_coding | tolerated(0.39) | benign(0.027) | TCGA-CN-4727-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
PNMA3 | SNV | Missense_Mutation | c.778G>A | p.Ala260Thr | p.A260T | Q9UL41 | protein_coding | tolerated(0.37) | benign(0.079) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PNMA3 | SNV | Missense_Mutation | rs782242475 | c.661C>T | p.Arg221Trp | p.R221W | Q9UL41 | protein_coding | tolerated(0.13) | probably_damaging(0.95) | TCGA-CD-8530-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | CR |
PNMA3 | SNV | Missense_Mutation | c.1156N>T | p.Arg386Trp | p.R386W | Q9UL41 | protein_coding | tolerated(0.21) | benign(0.01) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PNMA3 | SNV | Missense_Mutation | c.1053A>T | p.Glu351Asp | p.E351D | Q9UL41 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-D7-A4YU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | SD | |
PNMA3 | insertion | Frame_Shift_Ins | rs781795278 | c.254_255insG | p.Pro88AlafsTer10 | p.P88Afs*10 | Q9UL41 | protein_coding | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |