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Gene: PLEKHM3 |
Gene summary for PLEKHM3 |
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Gene information | Species | Human | Gene symbol | PLEKHM3 | Gene ID | 389072 |
Gene name | pleckstrin homology domain containing M3 | |
Gene Alias | DAPR | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6ZWE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389072 | PLEKHM3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.91e-02 | -2.61e-01 | 0.0155 |
389072 | PLEKHM3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.24e-02 | -2.67e-01 | 0.096 |
389072 | PLEKHM3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.42e-37 | 1.45e+00 | 0.3005 |
389072 | PLEKHM3 | A001-C-207 | Human | Colorectum | FAP | 1.51e-03 | -3.13e-01 | 0.1278 |
389072 | PLEKHM3 | A015-C-203 | Human | Colorectum | FAP | 3.74e-15 | -3.69e-01 | -0.1294 |
389072 | PLEKHM3 | A015-C-204 | Human | Colorectum | FAP | 2.80e-05 | -3.00e-01 | -0.0228 |
389072 | PLEKHM3 | A002-C-201 | Human | Colorectum | FAP | 8.05e-11 | -3.31e-01 | 0.0324 |
389072 | PLEKHM3 | A002-C-203 | Human | Colorectum | FAP | 2.10e-04 | -2.29e-01 | 0.2786 |
389072 | PLEKHM3 | A001-C-119 | Human | Colorectum | FAP | 5.89e-03 | -2.70e-01 | -0.1557 |
389072 | PLEKHM3 | A001-C-108 | Human | Colorectum | FAP | 2.08e-09 | -2.91e-01 | -0.0272 |
389072 | PLEKHM3 | A002-C-205 | Human | Colorectum | FAP | 8.94e-12 | -3.34e-01 | -0.1236 |
389072 | PLEKHM3 | A001-C-104 | Human | Colorectum | FAP | 3.55e-03 | -3.11e-01 | 0.0184 |
389072 | PLEKHM3 | A015-C-005 | Human | Colorectum | FAP | 4.16e-04 | -2.83e-01 | -0.0336 |
389072 | PLEKHM3 | A015-C-006 | Human | Colorectum | FAP | 5.39e-10 | -3.96e-01 | -0.0994 |
389072 | PLEKHM3 | A015-C-106 | Human | Colorectum | FAP | 1.67e-07 | -2.95e-01 | -0.0511 |
389072 | PLEKHM3 | A002-C-114 | Human | Colorectum | FAP | 5.39e-14 | -4.26e-01 | -0.1561 |
389072 | PLEKHM3 | A015-C-104 | Human | Colorectum | FAP | 1.34e-15 | -3.35e-01 | -0.1899 |
389072 | PLEKHM3 | A001-C-014 | Human | Colorectum | FAP | 5.72e-07 | -3.09e-01 | 0.0135 |
389072 | PLEKHM3 | A002-C-016 | Human | Colorectum | FAP | 1.08e-10 | -3.49e-01 | 0.0521 |
389072 | PLEKHM3 | A015-C-002 | Human | Colorectum | FAP | 4.79e-12 | -4.78e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHM3 | SNV | Missense_Mutation | c.985N>T | p.His329Tyr | p.H329Y | Q6ZWE6 | protein_coding | tolerated(0.2) | benign(0) | TCGA-39-5022-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PLEKHM3 | SNV | Missense_Mutation | novel | c.1636N>A | p.Asp546Asn | p.D546N | Q6ZWE6 | protein_coding | tolerated(0.44) | possibly_damaging(0.46) | TCGA-77-8154-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLEKHM3 | SNV | Missense_Mutation | novel | c.1333C>G | p.Gln445Glu | p.Q445E | Q6ZWE6 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PLEKHM3 | SNV | Missense_Mutation | novel | c.2235N>C | p.Glu745Asp | p.E745D | Q6ZWE6 | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
PLEKHM3 | SNV | Missense_Mutation | rs202021467 | c.1657N>T | p.Arg553Cys | p.R553C | Q6ZWE6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HO-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR |
PLEKHM3 | SNV | Missense_Mutation | novel | c.1858N>T | p.Ala620Ser | p.A620S | Q6ZWE6 | protein_coding | tolerated(0.54) | benign(0.079) | TCGA-CN-A497-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
PLEKHM3 | SNV | Missense_Mutation | novel | c.1783G>A | p.Ala595Thr | p.A595T | Q6ZWE6 | protein_coding | tolerated(0.08) | benign(0.129) | TCGA-CV-A45U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PLEKHM3 | SNV | Missense_Mutation | c.1808N>T | p.Arg603Leu | p.R603L | Q6ZWE6 | protein_coding | deleterious(0) | benign(0.011) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PLEKHM3 | SNV | Missense_Mutation | c.1335N>T | p.Gln445His | p.Q445H | Q6ZWE6 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLEKHM3 | SNV | Missense_Mutation | c.2081A>G | p.Tyr694Cys | p.Y694C | Q6ZWE6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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