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Gene: PFKM |
Gene summary for PFKM |
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Gene information | Species | Human | Gene symbol | PFKM | Gene ID | 5213 |
Gene name | phosphofructokinase, muscle | |
Gene Alias | ATP-PFK | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0000272 | UniProtAcc | A0A024R0Y5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5213 | PFKM | LZE24T | Human | Esophagus | ESCC | 1.46e-08 | 9.04e-02 | 0.0596 |
5213 | PFKM | P1T-E | Human | Esophagus | ESCC | 4.95e-02 | 1.14e-01 | 0.0875 |
5213 | PFKM | P2T-E | Human | Esophagus | ESCC | 7.87e-20 | 3.88e-01 | 0.1177 |
5213 | PFKM | P4T-E | Human | Esophagus | ESCC | 9.75e-11 | 2.02e-01 | 0.1323 |
5213 | PFKM | P5T-E | Human | Esophagus | ESCC | 3.61e-05 | -2.13e-02 | 0.1327 |
5213 | PFKM | P8T-E | Human | Esophagus | ESCC | 6.26e-16 | 1.51e-01 | 0.0889 |
5213 | PFKM | P9T-E | Human | Esophagus | ESCC | 3.47e-03 | -1.41e-02 | 0.1131 |
5213 | PFKM | P10T-E | Human | Esophagus | ESCC | 1.52e-14 | 2.89e-01 | 0.116 |
5213 | PFKM | P11T-E | Human | Esophagus | ESCC | 3.94e-03 | 9.95e-02 | 0.1426 |
5213 | PFKM | P12T-E | Human | Esophagus | ESCC | 7.32e-21 | 2.74e-01 | 0.1122 |
5213 | PFKM | P15T-E | Human | Esophagus | ESCC | 3.39e-14 | 2.18e-01 | 0.1149 |
5213 | PFKM | P16T-E | Human | Esophagus | ESCC | 4.71e-25 | 4.05e-01 | 0.1153 |
5213 | PFKM | P17T-E | Human | Esophagus | ESCC | 5.77e-10 | 3.07e-01 | 0.1278 |
5213 | PFKM | P19T-E | Human | Esophagus | ESCC | 1.62e-03 | 2.06e-01 | 0.1662 |
5213 | PFKM | P21T-E | Human | Esophagus | ESCC | 9.37e-10 | 2.90e-01 | 0.1617 |
5213 | PFKM | P22T-E | Human | Esophagus | ESCC | 4.19e-21 | 2.42e-01 | 0.1236 |
5213 | PFKM | P23T-E | Human | Esophagus | ESCC | 7.15e-09 | 3.35e-01 | 0.108 |
5213 | PFKM | P24T-E | Human | Esophagus | ESCC | 2.31e-13 | 3.97e-01 | 0.1287 |
5213 | PFKM | P26T-E | Human | Esophagus | ESCC | 9.42e-25 | 5.44e-01 | 0.1276 |
5213 | PFKM | P27T-E | Human | Esophagus | ESCC | 3.43e-15 | 2.70e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:000913219 | Esophagus | ESCC | nucleoside diphosphate metabolic process | 77/8552 | 124/18723 | 1.65e-04 | 1.09e-03 | 77 |
GO:000918520 | Esophagus | ESCC | ribonucleoside diphosphate metabolic process | 66/8552 | 106/18723 | 4.21e-04 | 2.39e-03 | 66 |
GO:001605216 | Esophagus | ESCC | carbohydrate catabolic process | 91/8552 | 154/18723 | 5.39e-04 | 2.97e-03 | 91 |
GO:000913520 | Esophagus | ESCC | purine nucleoside diphosphate metabolic process | 63/8552 | 103/18723 | 1.10e-03 | 5.52e-03 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0523018 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0123023 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0001016 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0492214 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0523019 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa0415213 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa04919113 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0123033 | Esophagus | ESCC | Biosynthesis of amino acids | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0001017 | Esophagus | ESCC | Glycolysis / Gluconeogenesis | 42/4205 | 67/8465 | 2.15e-02 | 4.78e-02 | 2.45e-02 | 42 |
hsa0492215 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0120014 | Oral cavity | OSCC | Carbon metabolism | 74/3704 | 115/8465 | 6.10e-06 | 3.05e-05 | 1.55e-05 | 74 |
hsa0523016 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa0406627 | Oral cavity | OSCC | HIF-1 signaling pathway | 68/3704 | 109/8465 | 6.30e-05 | 2.48e-04 | 1.26e-04 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PFKM | SNV | Missense_Mutation | rs766431669 | c.434N>T | p.Ser145Leu | p.S145L | P08237 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PFKM | insertion | Frame_Shift_Ins | novel | c.2316dupT | p.Ala773CysfsTer14 | p.A773Cfs*14 | P08237 | protein_coding | TCGA-A5-A3LO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
PFKM | insertion | Frame_Shift_Ins | novel | c.631_632insCT | p.Gln211ProfsTer18 | p.Q211Pfs*18 | P08237 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
PFKM | SNV | Missense_Mutation | c.2201A>C | p.Gln734Pro | p.Q734P | P08237 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PFKM | SNV | Missense_Mutation | c.709N>A | p.Asp237Asn | p.D237N | P08237 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
PFKM | SNV | Missense_Mutation | rs201838518 | c.1217T>C | p.Val406Ala | p.V406A | P08237 | protein_coding | deleterious(0) | possibly_damaging(0.735) | TCGA-21-1082-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PFKM | SNV | Missense_Mutation | c.1626N>C | p.Arg542Ser | p.R542S | P08237 | protein_coding | deleterious(0.03) | benign(0.023) | TCGA-22-4593-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PFKM | SNV | Missense_Mutation | c.2204A>T | p.Gln735Leu | p.Q735L | P08237 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PFKM | SNV | Missense_Mutation | c.1594N>C | p.Gly532Arg | p.G532R | P08237 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-66-2788-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PFKM | SNV | Missense_Mutation | novel | c.823N>C | p.Val275Leu | p.V275L | P08237 | protein_coding | deleterious(0) | benign(0.177) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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