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Gene: PDE4A |
Gene summary for PDE4A |
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Gene information | Species | Human | Gene symbol | PDE4A | Gene ID | 5141 |
Gene name | phosphodiesterase 4A | |
Gene Alias | DPDE2 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P27815 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5141 | PDE4A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.16e-02 | 2.19e-01 | 0.0155 |
5141 | PDE4A | HTA11_347_2000001011 | Human | Colorectum | AD | 3.33e-06 | 3.25e-01 | -0.1954 |
5141 | PDE4A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.22e-03 | 3.61e-01 | -0.1464 |
5141 | PDE4A | HTA11_866_2000001011 | Human | Colorectum | AD | 2.73e-15 | 5.55e-01 | -0.1001 |
5141 | PDE4A | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.65e-03 | 3.31e-01 | -0.059 |
5141 | PDE4A | HTA11_546_2000001011 | Human | Colorectum | AD | 2.72e-03 | 4.59e-01 | -0.0842 |
5141 | PDE4A | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.08e-02 | 5.33e-01 | -0.0177 |
5141 | PDE4A | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.21e-10 | 6.90e-01 | 0.0338 |
5141 | PDE4A | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.18e-23 | 7.78e-01 | 0.0674 |
5141 | PDE4A | male-WTA | Human | Thyroid | PTC | 3.40e-02 | 4.84e-02 | 0.1037 |
5141 | PDE4A | PTC01 | Human | Thyroid | PTC | 1.52e-02 | 2.96e-02 | 0.1899 |
5141 | PDE4A | PTC04 | Human | Thyroid | PTC | 5.96e-08 | 1.51e-01 | 0.1927 |
5141 | PDE4A | PTC05 | Human | Thyroid | PTC | 1.92e-03 | 1.68e-01 | 0.2065 |
5141 | PDE4A | PTC06 | Human | Thyroid | PTC | 1.05e-03 | 1.20e-01 | 0.2057 |
5141 | PDE4A | PTC07 | Human | Thyroid | PTC | 1.07e-13 | 2.09e-01 | 0.2044 |
5141 | PDE4A | ATC13 | Human | Thyroid | ATC | 7.41e-25 | 4.27e-01 | 0.34 |
5141 | PDE4A | ATC2 | Human | Thyroid | ATC | 1.08e-07 | 6.21e-01 | 0.34 |
5141 | PDE4A | ATC5 | Human | Thyroid | ATC | 1.46e-27 | 4.73e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0006195 | Colorectum | AD | purine nucleotide catabolic process | 18/3918 | 46/18723 | 3.67e-03 | 2.60e-02 | 18 |
GO:0072523 | Colorectum | AD | purine-containing compound catabolic process | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa049281 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE4A | SNV | Missense_Mutation | c.1087N>C | p.Glu363Gln | p.E363Q | P27815 | protein_coding | tolerated(0.06) | benign(0.028) | TCGA-MP-A4T6-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PDE4A | SNV | Missense_Mutation | c.964N>A | p.Pro322Thr | p.P322T | P27815 | protein_coding | tolerated_low_confidence(0.13) | benign(0.101) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDE4A | SNV | Missense_Mutation | novel | c.1459N>G | p.Asn487Asp | p.N487D | P27815 | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE4A | SNV | Missense_Mutation | novel | c.1461N>G | p.Asn487Lys | p.N487K | P27815 | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE4A | SNV | Missense_Mutation | novel | c.637G>T | p.Gly213Cys | p.G213C | P27815 | protein_coding | deleterious(0.01) | possibly_damaging(0.786) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDE4A | SNV | Missense_Mutation | novel | c.164C>T | p.Ala55Val | p.A55V | P27815 | protein_coding | deleterious_low_confidence(0.01) | benign(0.135) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE4A | SNV | Missense_Mutation | novel | c.2360G>A | p.Gly787Asp | p.G787D | P27815 | protein_coding | tolerated_low_confidence(0.38) | benign(0) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PDE4A | SNV | Missense_Mutation | novel | c.199N>A | p.Arg67Ser | p.R67S | P27815 | protein_coding | deleterious_low_confidence(0.03) | benign(0.357) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE4A | SNV | Missense_Mutation | novel | c.1390N>T | p.Leu464Phe | p.L464F | P27815 | protein_coding | deleterious(0.02) | possibly_damaging(0.806) | TCGA-94-7557-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE4A | SNV | Missense_Mutation | c.1910N>T | p.Ser637Phe | p.S637F | P27815 | protein_coding | deleterious(0.01) | benign(0.159) | TCGA-94-7557-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | ENPROFYLLINE | ENPROFYLLINE | ||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | AVE-8112 | 24343458 | ||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1370561 | AMINOPHYLLINE | |
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | Enprofylline | ENPROFYLLINE | ||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | AN-2898 | |||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | MM36 topical ointment | |||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | RONOMILAST | |||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | OX914 | |||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | THEOPHYLLINE | THEOPHYLLINE | ||
5141 | PDE4A | DRUGGABLE GENOME, ENZYME | DYPHYLLINE | DYPHYLLINE |
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