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Gene: P4HA2 |
Gene summary for P4HA2 |
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Gene information | Species | Human | Gene symbol | P4HA2 | Gene ID | 8974 |
Gene name | prolyl 4-hydroxylase subunit alpha 2 | |
Gene Alias | MYP25 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | O15460 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8974 | P4HA2 | LZE2T | Human | Esophagus | ESCC | 6.16e-03 | 3.41e-01 | 0.082 |
8974 | P4HA2 | LZE4T | Human | Esophagus | ESCC | 1.72e-06 | 4.75e-01 | 0.0811 |
8974 | P4HA2 | LZE8T | Human | Esophagus | ESCC | 2.27e-05 | 1.40e-01 | 0.067 |
8974 | P4HA2 | LZE20T | Human | Esophagus | ESCC | 3.42e-08 | 1.97e-01 | 0.0662 |
8974 | P4HA2 | LZE22T | Human | Esophagus | ESCC | 1.61e-08 | 3.15e-01 | 0.068 |
8974 | P4HA2 | LZE6T | Human | Esophagus | ESCC | 2.52e-03 | 2.29e-01 | 0.0845 |
8974 | P4HA2 | P2T-E | Human | Esophagus | ESCC | 2.05e-36 | 8.17e-01 | 0.1177 |
8974 | P4HA2 | P4T-E | Human | Esophagus | ESCC | 8.70e-24 | 8.10e-01 | 0.1323 |
8974 | P4HA2 | P5T-E | Human | Esophagus | ESCC | 3.18e-19 | 5.47e-01 | 0.1327 |
8974 | P4HA2 | P8T-E | Human | Esophagus | ESCC | 9.04e-14 | 1.38e-01 | 0.0889 |
8974 | P4HA2 | P9T-E | Human | Esophagus | ESCC | 5.46e-07 | 3.05e-01 | 0.1131 |
8974 | P4HA2 | P10T-E | Human | Esophagus | ESCC | 8.21e-10 | 2.48e-01 | 0.116 |
8974 | P4HA2 | P11T-E | Human | Esophagus | ESCC | 4.87e-22 | 1.20e+00 | 0.1426 |
8974 | P4HA2 | P12T-E | Human | Esophagus | ESCC | 4.59e-22 | 5.66e-01 | 0.1122 |
8974 | P4HA2 | P15T-E | Human | Esophagus | ESCC | 4.37e-29 | 7.58e-01 | 0.1149 |
8974 | P4HA2 | P16T-E | Human | Esophagus | ESCC | 1.14e-22 | 4.83e-01 | 0.1153 |
8974 | P4HA2 | P17T-E | Human | Esophagus | ESCC | 3.54e-13 | 1.08e+00 | 0.1278 |
8974 | P4HA2 | P19T-E | Human | Esophagus | ESCC | 1.50e-14 | 1.39e+00 | 0.1662 |
8974 | P4HA2 | P20T-E | Human | Esophagus | ESCC | 1.14e-30 | 7.88e-01 | 0.1124 |
8974 | P4HA2 | P21T-E | Human | Esophagus | ESCC | 3.45e-40 | 8.86e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0022900110 | Esophagus | ESCC | electron transport chain | 133/8552 | 175/18723 | 2.18e-16 | 1.67e-14 | 133 |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:00181263 | Esophagus | ESCC | protein hydroxylation | 23/8552 | 27/18723 | 2.60e-05 | 2.19e-04 | 23 |
GO:00195114 | Esophagus | ESCC | peptidyl-proline hydroxylation | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
GO:00184014 | Esophagus | ESCC | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:000609112 | Liver | Cirrhotic | generation of precursor metabolites and energy | 238/4634 | 490/18723 | 6.85e-31 | 1.07e-27 | 238 |
GO:002290012 | Liver | Cirrhotic | electron transport chain | 111/4634 | 175/18723 | 1.94e-27 | 1.52e-24 | 111 |
GO:00182084 | Liver | Cirrhotic | peptidyl-proline modification | 26/4634 | 58/18723 | 6.65e-04 | 5.04e-03 | 26 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:002290022 | Liver | HCC | electron transport chain | 134/7958 | 175/18723 | 3.32e-20 | 4.68e-18 | 134 |
GO:001820811 | Liver | HCC | peptidyl-proline modification | 42/7958 | 58/18723 | 3.73e-06 | 4.85e-05 | 42 |
GO:0018126 | Liver | HCC | protein hydroxylation | 18/7958 | 27/18723 | 9.75e-03 | 3.66e-02 | 18 |
GO:002290018 | Oral cavity | OSCC | electron transport chain | 126/7305 | 175/18723 | 6.65e-19 | 8.42e-17 | 126 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:00182088 | Oral cavity | OSCC | peptidyl-proline modification | 42/7305 | 58/18723 | 2.49e-07 | 3.92e-06 | 42 |
GO:00181262 | Oral cavity | OSCC | protein hydroxylation | 22/7305 | 27/18723 | 7.89e-06 | 8.49e-05 | 22 |
GO:00195113 | Oral cavity | OSCC | peptidyl-proline hydroxylation | 13/7305 | 15/18723 | 2.07e-04 | 1.36e-03 | 13 |
GO:00184013 | Oral cavity | OSCC | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 9/7305 | 10/18723 | 1.36e-03 | 6.62e-03 | 9 |
GO:002290019 | Oral cavity | LP | electron transport chain | 108/4623 | 175/18723 | 2.21e-25 | 9.90e-23 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0033021 | Liver | HCC | Arginine and proline metabolism | 33/4020 | 50/8465 | 6.28e-03 | 1.77e-02 | 9.83e-03 | 33 |
hsa0033031 | Liver | HCC | Arginine and proline metabolism | 33/4020 | 50/8465 | 6.28e-03 | 1.77e-02 | 9.83e-03 | 33 |
hsa0033010 | Oral cavity | OSCC | Arginine and proline metabolism | 30/3704 | 50/8465 | 1.50e-02 | 3.26e-02 | 1.66e-02 | 30 |
hsa0033013 | Oral cavity | OSCC | Arginine and proline metabolism | 30/3704 | 50/8465 | 1.50e-02 | 3.26e-02 | 1.66e-02 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
P4HA2 | SNV | Missense_Mutation | c.836G>T | p.Arg279Met | p.R279M | O15460 | protein_coding | tolerated(0.07) | possibly_damaging(0.634) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
P4HA2 | SNV | Missense_Mutation | novel | c.953N>T | p.Arg318Met | p.R318M | O15460 | protein_coding | deleterious(0) | possibly_damaging(0.627) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
P4HA2 | SNV | Missense_Mutation | rs148040234 | c.1015G>A | p.Val339Ile | p.V339I | O15460 | protein_coding | tolerated(0.18) | benign(0.089) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
P4HA2 | SNV | Missense_Mutation | rs148040234 | c.1015G>A | p.Val339Ile | p.V339I | O15460 | protein_coding | tolerated(0.18) | benign(0.089) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
P4HA2 | SNV | Missense_Mutation | rs201860203 | c.296C>T | p.Ala99Val | p.A99V | O15460 | protein_coding | tolerated(0.16) | benign(0.105) | TCGA-BR-6455-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide phosphate | PD |
P4HA2 | SNV | Missense_Mutation | c.97N>A | p.Leu33Met | p.L33M | O15460 | protein_coding | tolerated(0.07) | probably_damaging(1) | TCGA-CG-4441-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
P4HA2 | SNV | Missense_Mutation | rs200845342 | c.1463N>G | p.Asn488Ser | p.N488S | O15460 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D7-6815-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
P4HA2 | SNV | Missense_Mutation | rs149593706 | c.691N>T | p.Arg231Cys | p.R231C | O15460 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
P4HA2 | deletion | Frame_Shift_Del | novel | c.781delN | p.Thr261ArgfsTer2 | p.T261Rfs*2 | O15460 | protein_coding | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
P4HA2 | deletion | Frame_Shift_Del | c.1526delN | p.Gly509AlafsTer18 | p.G509Afs*18 | O15460 | protein_coding | TCGA-VQ-A8DU-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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