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Gene: ORC2 |
Gene summary for ORC2 |
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Gene information | Species | Human | Gene symbol | ORC2 | Gene ID | 4999 |
Gene name | origin recognition complex subunit 2 | |
Gene Alias | ORC2L | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R411 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4999 | ORC2 | CCI_2 | Human | Cervix | CC | 1.78e-09 | 9.08e-01 | 0.5249 |
4999 | ORC2 | CCI_3 | Human | Cervix | CC | 7.35e-06 | 5.09e-01 | 0.516 |
4999 | ORC2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.34e-04 | -3.33e-01 | 0.0155 |
4999 | ORC2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.26e-03 | 3.85e-01 | -0.1954 |
4999 | ORC2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.47e-07 | -4.41e-01 | 0.096 |
4999 | ORC2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.38e-04 | -2.42e-01 | 0.3005 |
4999 | ORC2 | A001-C-207 | Human | Colorectum | FAP | 1.36e-05 | -4.61e-01 | 0.1278 |
4999 | ORC2 | A015-C-203 | Human | Colorectum | FAP | 3.56e-27 | -4.46e-01 | -0.1294 |
4999 | ORC2 | A015-C-204 | Human | Colorectum | FAP | 2.36e-07 | -4.76e-01 | -0.0228 |
4999 | ORC2 | A014-C-040 | Human | Colorectum | FAP | 2.36e-02 | -4.87e-01 | -0.1184 |
4999 | ORC2 | A002-C-201 | Human | Colorectum | FAP | 5.48e-11 | -4.12e-01 | 0.0324 |
4999 | ORC2 | A002-C-203 | Human | Colorectum | FAP | 1.02e-03 | -2.48e-01 | 0.2786 |
4999 | ORC2 | A001-C-119 | Human | Colorectum | FAP | 2.25e-07 | -5.29e-01 | -0.1557 |
4999 | ORC2 | A001-C-108 | Human | Colorectum | FAP | 7.16e-19 | -4.32e-01 | -0.0272 |
4999 | ORC2 | A002-C-205 | Human | Colorectum | FAP | 1.43e-16 | -5.20e-01 | -0.1236 |
4999 | ORC2 | A001-C-104 | Human | Colorectum | FAP | 1.19e-09 | -3.91e-01 | 0.0184 |
4999 | ORC2 | A015-C-005 | Human | Colorectum | FAP | 3.94e-02 | -3.25e-01 | -0.0336 |
4999 | ORC2 | A015-C-006 | Human | Colorectum | FAP | 3.19e-15 | -6.18e-01 | -0.0994 |
4999 | ORC2 | A015-C-106 | Human | Colorectum | FAP | 3.22e-12 | -3.32e-01 | -0.0511 |
4999 | ORC2 | A002-C-114 | Human | Colorectum | FAP | 2.12e-15 | -5.05e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:00062701 | Esophagus | ESCC | DNA replication initiation | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:001905822 | Liver | HCC | viral life cycle | 209/7958 | 317/18723 | 2.05e-17 | 2.09e-15 | 209 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:001907922 | Liver | HCC | viral genome replication | 94/7958 | 131/18723 | 1.02e-11 | 4.18e-10 | 94 |
GO:003304421 | Liver | HCC | regulation of chromosome organization | 125/7958 | 187/18723 | 1.35e-11 | 5.40e-10 | 125 |
GO:005079212 | Liver | HCC | regulation of viral process | 109/7958 | 164/18723 | 4.52e-10 | 1.45e-08 | 109 |
GO:190390012 | Liver | HCC | regulation of viral life cycle | 94/7958 | 148/18723 | 1.93e-07 | 3.49e-06 | 94 |
GO:004506922 | Liver | HCC | regulation of viral genome replication | 59/7958 | 85/18723 | 4.66e-07 | 7.61e-06 | 59 |
GO:200125211 | Liver | HCC | positive regulation of chromosome organization | 55/7958 | 82/18723 | 5.97e-06 | 7.35e-05 | 55 |
GO:004852511 | Liver | HCC | negative regulation of viral process | 59/7958 | 92/18723 | 2.28e-05 | 2.41e-04 | 59 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:0040029 | Liver | HCC | regulation of gene expression, epigenetic | 61/7958 | 105/18723 | 9.02e-04 | 5.31e-03 | 61 |
GO:00450711 | Liver | HCC | negative regulation of viral genome replication | 35/7958 | 56/18723 | 2.00e-03 | 1.01e-02 | 35 |
GO:0039694 | Liver | HCC | viral RNA genome replication | 22/7958 | 35/18723 | 1.21e-02 | 4.41e-02 | 22 |
GO:00062605 | Skin | AK | DNA replication | 40/1910 | 260/18723 | 5.49e-03 | 3.03e-02 | 40 |
GO:000626012 | Skin | cSCC | DNA replication | 106/4864 | 260/18723 | 1.18e-07 | 2.77e-06 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041106 | Cervix | CC | Cell cycle | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0411013 | Cervix | CC | Cell cycle | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04110 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa041101 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ORC2 | SNV | Missense_Mutation | c.830N>T | p.Ser277Ile | p.S277I | Q13416 | protein_coding | tolerated(0.09) | possibly_damaging(0.571) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ORC2 | SNV | Missense_Mutation | novel | c.420G>T | p.Lys140Asn | p.K140N | Q13416 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ORC2 | SNV | Missense_Mutation | novel | c.268G>A | p.Gly90Ser | p.G90S | Q13416 | protein_coding | tolerated(0.06) | benign(0.048) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ORC2 | SNV | Missense_Mutation | novel | c.257C>T | p.Ser86Phe | p.S86F | Q13416 | protein_coding | tolerated(0.1) | benign(0.101) | TCGA-63-A5MP-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ORC2 | SNV | Missense_Mutation | novel | c.571N>A | p.Asp191Asn | p.D191N | Q13416 | protein_coding | tolerated(0.15) | benign(0.343) | TCGA-CV-A465-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ORC2 | SNV | Missense_Mutation | novel | c.932N>G | p.Ile311Ser | p.I311S | Q13416 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-H7-A6C4-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ORC2 | SNV | Missense_Mutation | novel | c.257C>G | p.Ser86Cys | p.S86C | Q13416 | protein_coding | tolerated(0.09) | benign(0) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ORC2 | SNV | Missense_Mutation | c.544G>A | p.Glu182Lys | p.E182K | Q13416 | protein_coding | deleterious(0.01) | possibly_damaging(0.746) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
ORC2 | SNV | Missense_Mutation | novel | c.1720N>C | p.Glu574Gln | p.E574Q | Q13416 | protein_coding | deleterious(0.04) | benign(0.049) | TCGA-BR-7704-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ORC2 | SNV | Missense_Mutation | rs542775161 | c.758T>C | p.Leu253Ser | p.L253S | Q13416 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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