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Gene: NUMB |
Gene summary for NUMB |
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Gene information | Species | Human | Gene symbol | NUMB | Gene ID | 8650 |
Gene name | NUMB endocytic adaptor protein | |
Gene Alias | C14orf41 | |
Cytomap | 14q24.2-q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R6F4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8650 | NUMB | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.40e-17 | -5.36e-01 | 0.0155 |
8650 | NUMB | HTA11_347_2000001011 | Human | Colorectum | AD | 8.86e-11 | 5.99e-01 | -0.1954 |
8650 | NUMB | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.49e-02 | -2.72e-01 | -0.1207 |
8650 | NUMB | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.16e-03 | -4.80e-01 | -0.1462 |
8650 | NUMB | HTA11_866_3004761011 | Human | Colorectum | AD | 2.34e-06 | -4.22e-01 | 0.096 |
8650 | NUMB | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.90e-03 | -2.02e-01 | 0.0446 |
8650 | NUMB | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.38e-11 | -4.14e-01 | 0.0674 |
8650 | NUMB | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.44e-03 | -6.32e-01 | 0.0397 |
8650 | NUMB | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.26e-04 | -3.38e-01 | 0.294 |
8650 | NUMB | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.54e-10 | -4.86e-01 | 0.3859 |
8650 | NUMB | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.68e-04 | -4.41e-01 | 0.2585 |
8650 | NUMB | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.26e-22 | -6.18e-01 | 0.3005 |
8650 | NUMB | F007 | Human | Colorectum | FAP | 1.61e-05 | -4.19e-01 | 0.1176 |
8650 | NUMB | A001-C-207 | Human | Colorectum | FAP | 2.29e-10 | -5.70e-01 | 0.1278 |
8650 | NUMB | A015-C-203 | Human | Colorectum | FAP | 4.65e-42 | -7.11e-01 | -0.1294 |
8650 | NUMB | A015-C-204 | Human | Colorectum | FAP | 1.69e-09 | -4.60e-01 | -0.0228 |
8650 | NUMB | A014-C-040 | Human | Colorectum | FAP | 3.77e-08 | -6.22e-01 | -0.1184 |
8650 | NUMB | A002-C-201 | Human | Colorectum | FAP | 1.05e-24 | -6.80e-01 | 0.0324 |
8650 | NUMB | A002-C-203 | Human | Colorectum | FAP | 1.02e-02 | -3.50e-01 | 0.2786 |
8650 | NUMB | A001-C-119 | Human | Colorectum | FAP | 4.12e-08 | -3.27e-01 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:0043112 | Colorectum | AD | receptor metabolic process | 62/3918 | 166/18723 | 8.18e-07 | 2.85e-05 | 62 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
GO:1903077 | Colorectum | AD | negative regulation of protein localization to plasma membrane | 13/3918 | 24/18723 | 3.45e-04 | 4.03e-03 | 13 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:1904376 | Colorectum | AD | negative regulation of protein localization to cell periphery | 13/3918 | 26/18723 | 9.41e-04 | 8.92e-03 | 13 |
GO:1903828 | Colorectum | AD | negative regulation of cellular protein localization | 39/3918 | 117/18723 | 1.18e-03 | 1.06e-02 | 39 |
GO:0034332 | Colorectum | AD | adherens junction organization | 20/3918 | 49/18723 | 1.23e-03 | 1.09e-02 | 20 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0048259 | Colorectum | AD | regulation of receptor-mediated endocytosis | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:0099072 | Colorectum | AD | regulation of postsynaptic membrane neurotransmitter receptor levels | 22/3918 | 62/18723 | 5.72e-03 | 3.64e-02 | 22 |
GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0433021 | Oral cavity | NEOLP | Notch signaling pathway | 21/1112 | 62/8465 | 2.23e-05 | 1.87e-04 | 1.18e-04 | 21 |
hsa0433031 | Oral cavity | NEOLP | Notch signaling pathway | 21/1112 | 62/8465 | 2.23e-05 | 1.87e-04 | 1.18e-04 | 21 |
hsa043304 | Prostate | BPH | Notch signaling pathway | 21/1718 | 62/8465 | 8.53e-03 | 2.68e-02 | 1.66e-02 | 21 |
hsa0433011 | Prostate | BPH | Notch signaling pathway | 21/1718 | 62/8465 | 8.53e-03 | 2.68e-02 | 1.66e-02 | 21 |
hsa043302 | Prostate | Tumor | Notch signaling pathway | 22/1791 | 62/8465 | 6.45e-03 | 2.16e-02 | 1.34e-02 | 22 |
hsa043303 | Prostate | Tumor | Notch signaling pathway | 22/1791 | 62/8465 | 6.45e-03 | 2.16e-02 | 1.34e-02 | 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUMB | insertion | In_Frame_Ins | novel | c.1268_1269insACTGCT | p.Ala423_Ala424insLeuLeu | p.A423_A424insLL | P49757 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NUMB | insertion | Frame_Shift_Ins | novel | c.1383_1384insAGGAA | p.Pro462ArgfsTer133 | p.P462Rfs*133 | P49757 | protein_coding | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NUMB | insertion | Frame_Shift_Ins | novel | c.1246_1247insT | p.Glu416ValfsTer19 | p.E416Vfs*19 | P49757 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NUMB | insertion | Frame_Shift_Ins | novel | c.1245_1246insTC | p.Glu416SerfsTer30 | p.E416Sfs*30 | P49757 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NUMB | insertion | Frame_Shift_Ins | novel | c.1383_1384insGTAGGAA | p.Pro462ValfsTer64 | p.P462Vfs*64 | P49757 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NUMB | deletion | In_Frame_Del | novel | c.51_53delAGA | p.Glu18del | p.E18del | P49757 | protein_coding | TCGA-D1-A1NW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
NUMB | SNV | Missense_Mutation | c.1118T>G | p.Phe373Cys | p.F373C | P49757 | protein_coding | tolerated(0.11) | benign(0.371) | TCGA-DD-A4ND-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
NUMB | SNV | Missense_Mutation | c.981N>G | p.Ile327Met | p.I327M | P49757 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-44-2662-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Other, specify in notesGSK Mage Vaccine Study | rec | PD | |
NUMB | SNV | Missense_Mutation | c.1357N>T | p.Ala453Ser | p.A453S | P49757 | protein_coding | tolerated(0.08) | benign(0.019) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
NUMB | SNV | Missense_Mutation | novel | c.785N>A | p.Pro262Gln | p.P262Q | P49757 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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