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Gene: NSRP1 |
Gene summary for NSRP1 |
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Gene information | Species | Human | Gene symbol | NSRP1 | Gene ID | 84081 |
Gene name | nuclear speckle splicing regulatory protein 1 | |
Gene Alias | CCDC55 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A024QZ33 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84081 | NSRP1 | LZE2T | Human | Esophagus | ESCC | 5.57e-03 | 5.59e-02 | 0.082 |
84081 | NSRP1 | LZE4T | Human | Esophagus | ESCC | 8.67e-11 | 2.40e-01 | 0.0811 |
84081 | NSRP1 | LZE7T | Human | Esophagus | ESCC | 2.63e-06 | 3.53e-01 | 0.0667 |
84081 | NSRP1 | LZE8T | Human | Esophagus | ESCC | 4.03e-06 | 6.01e-02 | 0.067 |
84081 | NSRP1 | LZE20T | Human | Esophagus | ESCC | 3.79e-05 | -4.57e-02 | 0.0662 |
84081 | NSRP1 | LZE22D1 | Human | Esophagus | HGIN | 4.97e-02 | 8.66e-02 | 0.0595 |
84081 | NSRP1 | LZE22T | Human | Esophagus | ESCC | 1.19e-04 | 3.88e-01 | 0.068 |
84081 | NSRP1 | LZE24T | Human | Esophagus | ESCC | 2.23e-14 | 4.68e-01 | 0.0596 |
84081 | NSRP1 | LZE22D3 | Human | Esophagus | HGIN | 8.94e-04 | 2.08e-01 | 0.0653 |
84081 | NSRP1 | LZE21T | Human | Esophagus | ESCC | 6.12e-04 | 2.22e-01 | 0.0655 |
84081 | NSRP1 | LZE6T | Human | Esophagus | ESCC | 1.54e-07 | 4.23e-03 | 0.0845 |
84081 | NSRP1 | P1T-E | Human | Esophagus | ESCC | 9.90e-03 | 3.21e-01 | 0.0875 |
84081 | NSRP1 | P2T-E | Human | Esophagus | ESCC | 2.62e-17 | 2.90e-01 | 0.1177 |
84081 | NSRP1 | P4T-E | Human | Esophagus | ESCC | 1.20e-20 | 3.84e-01 | 0.1323 |
84081 | NSRP1 | P5T-E | Human | Esophagus | ESCC | 1.73e-18 | 2.04e-01 | 0.1327 |
84081 | NSRP1 | P8T-E | Human | Esophagus | ESCC | 2.15e-23 | 4.79e-01 | 0.0889 |
84081 | NSRP1 | P9T-E | Human | Esophagus | ESCC | 2.53e-15 | 3.91e-01 | 0.1131 |
84081 | NSRP1 | P10T-E | Human | Esophagus | ESCC | 1.42e-11 | 2.22e-01 | 0.116 |
84081 | NSRP1 | P11T-E | Human | Esophagus | ESCC | 7.02e-08 | 4.51e-01 | 0.1426 |
84081 | NSRP1 | P12T-E | Human | Esophagus | ESCC | 1.17e-15 | 3.56e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:190331120 | Esophagus | HGIN | regulation of mRNA metabolic process | 91/2587 | 288/18723 | 5.06e-15 | 9.78e-13 | 91 |
GO:005068419 | Esophagus | HGIN | regulation of mRNA processing | 55/2587 | 137/18723 | 2.17e-14 | 3.94e-12 | 55 |
GO:004802426 | Esophagus | HGIN | regulation of mRNA splicing, via spliceosome | 42/2587 | 101/18723 | 6.35e-12 | 7.78e-10 | 42 |
GO:000038018 | Esophagus | HGIN | alternative mRNA splicing, via spliceosome | 32/2587 | 77/18723 | 2.06e-09 | 1.54e-07 | 32 |
GO:000038118 | Esophagus | HGIN | regulation of alternative mRNA splicing, via spliceosome | 22/2587 | 60/18723 | 7.92e-06 | 2.40e-04 | 22 |
GO:000170118 | Esophagus | HGIN | in utero embryonic development | 77/2587 | 367/18723 | 9.56e-05 | 2.05e-03 | 77 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:0048024111 | Esophagus | ESCC | regulation of mRNA splicing, via spliceosome | 78/8552 | 101/18723 | 8.72e-11 | 2.66e-09 | 78 |
Page: 1 2 3 4 5 6 7 8 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NSRP1 | insertion | Frame_Shift_Ins | novel | c.1479_1480insTTTATCATTATTT | p.Ser494PhefsTer22 | p.S494Ffs*22 | Q9H0G5 | protein_coding | TCGA-BR-8676-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
NSRP1 | insertion | Frame_Shift_Ins | novel | c.1134_1135insTGCCTGGT | p.Lys379CysfsTer46 | p.K379Cfs*46 | Q9H0G5 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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