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Gene: NRXN2 |
Gene summary for NRXN2 |
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Gene information | Species | Human | Gene symbol | NRXN2 | Gene ID | 9379 |
Gene name | neurexin 2 | |
Gene Alias | NRXN2 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q9P2S2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9379 | NRXN2 | HCC1 | Human | Liver | HCC | 2.53e-11 | 2.75e+00 | 0.5336 |
9379 | NRXN2 | S014 | Human | Liver | HCC | 1.40e-09 | 2.95e-01 | 0.2254 |
9379 | NRXN2 | S015 | Human | Liver | HCC | 1.42e-09 | 4.76e-01 | 0.2375 |
9379 | NRXN2 | S016 | Human | Liver | HCC | 9.35e-20 | 6.04e-01 | 0.2243 |
9379 | NRXN2 | S027 | Human | Liver | HCC | 3.40e-03 | 2.13e-01 | 0.2446 |
9379 | NRXN2 | S028 | Human | Liver | HCC | 2.76e-10 | 3.45e-01 | 0.2503 |
9379 | NRXN2 | S029 | Human | Liver | HCC | 2.15e-13 | 3.66e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004409111 | Liver | HCC | membrane biogenesis | 37/7958 | 55/18723 | 1.79e-04 | 1.41e-03 | 37 |
GO:007170911 | Liver | HCC | membrane assembly | 34/7958 | 50/18723 | 2.38e-04 | 1.79e-03 | 34 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
NRXN2 | NLGN1 | NRXN2_NLGN1 | NRXN | Endometrium | ADJ |
NRXN2 | NLGN1 | NRXN2_NLGN1 | NRXN | Esophagus | ESCC |
NRXN2 | NLGN2 | NRXN2_NLGN2 | NRXN | Esophagus | ESCC |
NRXN2 | NLGN3 | NRXN2_NLGN3 | NRXN | Esophagus | ESCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRXN2 | SNV | Missense_Mutation | novel | c.891C>A | p.Phe297Leu | p.F297L | Q9P2S2 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NRXN2 | SNV | Missense_Mutation | novel | c.2632N>C | p.Phe878Leu | p.F878L | Q9P2S2 | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD |
NRXN2 | SNV | Missense_Mutation | c.4639C>T | p.Pro1547Ser | p.P1547S | Q9P2S2 | protein_coding | tolerated_low_confidence(0.12) | benign(0.085) | TCGA-CA-5797-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NRXN2 | SNV | Missense_Mutation | c.2117N>A | p.Arg706Gln | p.R706Q | Q9P2S2 | protein_coding | deleterious(0.04) | benign(0.388) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
NRXN2 | SNV | Missense_Mutation | c.3685C>T | p.Arg1229Cys | p.R1229C | Q9P2S2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NRXN2 | SNV | Missense_Mutation | c.4685N>T | p.Ala1562Val | p.A1562V | Q9P2S2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.012) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRXN2 | SNV | Missense_Mutation | c.3023N>A | p.Arg1008Lys | p.R1008K | Q9P2S2 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
NRXN2 | SNV | Missense_Mutation | c.1402N>A | p.Leu468Met | p.L468M | Q9P2S2 | protein_coding | deleterious(0.04) | probably_damaging(0.965) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
NRXN2 | SNV | Missense_Mutation | rs373695786 | c.2099N>A | p.Arg700His | p.R700H | Q9P2S2 | protein_coding | tolerated(0.4) | benign(0.018) | TCGA-D5-6920-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NRXN2 | SNV | Missense_Mutation | c.3538N>T | p.Arg1180Trp | p.R1180W | Q9P2S2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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