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Gene: NOS1 |
Gene summary for NOS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NOS1 | Gene ID | 4842 |
Gene name | nitric oxide synthase 1 | |
Gene Alias | IHPS1 | |
Cytomap | 12q24.22 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | A0PJJ7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4842 | NOS1 | P1T-E | Human | Esophagus | ESCC | 2.30e-04 | 4.03e-01 | 0.0875 |
4842 | NOS1 | P2T-E | Human | Esophagus | ESCC | 1.92e-10 | 1.38e-01 | 0.1177 |
4842 | NOS1 | P12T-E | Human | Esophagus | ESCC | 6.56e-11 | 1.23e-01 | 0.1122 |
4842 | NOS1 | P20T-E | Human | Esophagus | ESCC | 1.45e-06 | 2.15e-01 | 0.1124 |
4842 | NOS1 | P21T-E | Human | Esophagus | ESCC | 6.27e-14 | 2.52e-01 | 0.1617 |
4842 | NOS1 | P23T-E | Human | Esophagus | ESCC | 2.67e-03 | 1.71e-01 | 0.108 |
4842 | NOS1 | P27T-E | Human | Esophagus | ESCC | 2.79e-05 | 3.74e-02 | 0.1055 |
4842 | NOS1 | P28T-E | Human | Esophagus | ESCC | 4.14e-05 | 5.92e-02 | 0.1149 |
4842 | NOS1 | P31T-E | Human | Esophagus | ESCC | 5.57e-18 | 1.34e-01 | 0.1251 |
4842 | NOS1 | P47T-E | Human | Esophagus | ESCC | 8.95e-04 | 2.68e-02 | 0.1067 |
4842 | NOS1 | P54T-E | Human | Esophagus | ESCC | 5.11e-16 | 4.16e-01 | 0.0975 |
4842 | NOS1 | P62T-E | Human | Esophagus | ESCC | 2.15e-25 | 5.09e-01 | 0.1302 |
4842 | NOS1 | P75T-E | Human | Esophagus | ESCC | 2.42e-26 | 7.44e-01 | 0.1125 |
4842 | NOS1 | P76T-E | Human | Esophagus | ESCC | 1.92e-03 | 9.37e-03 | 0.1207 |
4842 | NOS1 | P79T-E | Human | Esophagus | ESCC | 5.13e-04 | 2.69e-02 | 0.1154 |
4842 | NOS1 | P80T-E | Human | Esophagus | ESCC | 1.91e-21 | 8.61e-01 | 0.155 |
4842 | NOS1 | P82T-E | Human | Esophagus | ESCC | 8.20e-09 | 4.57e-01 | 0.1072 |
4842 | NOS1 | P84T-E | Human | Esophagus | ESCC | 1.34e-05 | 3.04e-01 | 0.0933 |
4842 | NOS1 | P107T-E | Human | Esophagus | ESCC | 1.10e-10 | 2.16e-01 | 0.171 |
4842 | NOS1 | P127T-E | Human | Esophagus | ESCC | 1.86e-18 | 3.18e-01 | 0.0826 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0098901 | Colorectum | AD | regulation of cardiac muscle cell action potential | 15/3918 | 27/18723 | 8.20e-05 | 1.29e-03 | 15 |
GO:0006809 | Colorectum | AD | nitric oxide biosynthetic process | 30/3918 | 76/18723 | 1.72e-04 | 2.33e-03 | 30 |
GO:0030048 | Colorectum | AD | actin filament-based movement | 44/3918 | 127/18723 | 2.31e-04 | 2.99e-03 | 44 |
GO:0046209 | Colorectum | AD | nitric oxide metabolic process | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:2001057 | Colorectum | AD | reactive nitrogen species metabolic process | 31/3918 | 82/18723 | 3.37e-04 | 3.94e-03 | 31 |
GO:0045429 | Colorectum | AD | positive regulation of nitric oxide biosynthetic process | 17/3918 | 40/18723 | 1.66e-03 | 1.38e-02 | 17 |
GO:1904407 | Colorectum | AD | positive regulation of nitric oxide metabolic process | 17/3918 | 41/18723 | 2.29e-03 | 1.79e-02 | 17 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0080164 | Colorectum | AD | regulation of nitric oxide metabolic process | 23/3918 | 64/18723 | 3.99e-03 | 2.80e-02 | 23 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0098974 | Colorectum | AD | postsynaptic actin cytoskeleton organization | 7/3918 | 12/18723 | 5.09e-03 | 3.38e-02 | 7 |
GO:0045428 | Colorectum | AD | regulation of nitric oxide biosynthetic process | 22/3918 | 62/18723 | 5.72e-03 | 3.64e-02 | 22 |
GO:0051353 | Colorectum | AD | positive regulation of oxidoreductase activity | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:0032411 | Colorectum | AD | positive regulation of transporter activity | 37/3918 | 120/18723 | 6.82e-03 | 4.22e-02 | 37 |
GO:00068091 | Colorectum | SER | nitric oxide biosynthetic process | 27/2897 | 76/18723 | 1.38e-05 | 4.28e-04 | 27 |
GO:00462091 | Colorectum | SER | nitric oxide metabolic process | 28/2897 | 81/18723 | 1.73e-05 | 5.15e-04 | 28 |
GO:20010571 | Colorectum | SER | reactive nitrogen species metabolic process | 28/2897 | 82/18723 | 2.24e-05 | 6.43e-04 | 28 |
GO:00300481 | Colorectum | SER | actin filament-based movement | 38/2897 | 127/18723 | 2.80e-05 | 7.56e-04 | 38 |
GO:00991731 | Colorectum | SER | postsynapse organization | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00989011 | Colorectum | SER | regulation of cardiac muscle cell action potential | 12/2897 | 27/18723 | 3.27e-04 | 5.22e-03 | 12 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa049268 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0492616 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414521 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa0033021 | Liver | HCC | Arginine and proline metabolism | 33/4020 | 50/8465 | 6.28e-03 | 1.77e-02 | 9.83e-03 | 33 |
hsa049262 | Liver | HCC | Relaxin signaling pathway | 75/4020 | 129/8465 | 9.33e-03 | 2.46e-02 | 1.37e-02 | 75 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0414531 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOS1 | SNV | Missense_Mutation | c.4064N>A | p.Pro1355Gln | p.P1355Q | P29475 | protein_coding | deleterious(0.03) | possibly_damaging(0.744) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
NOS1 | SNV | Missense_Mutation | rs375069851 | c.3163C>T | p.Arg1055Cys | p.R1055C | P29475 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NOS1 | SNV | Missense_Mutation | rs749094921 | c.3043N>A | p.Glu1015Lys | p.E1015K | P29475 | protein_coding | tolerated(0.29) | benign(0.034) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOS1 | SNV | Missense_Mutation | c.1141N>A | p.Ala381Thr | p.A381T | P29475 | protein_coding | deleterious(0.04) | benign(0.051) | TCGA-AF-5654-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOS1 | SNV | Missense_Mutation | novel | c.706N>G | p.Met236Val | p.M236V | P29475 | protein_coding | tolerated_low_confidence(0.72) | benign(0) | TCGA-AG-4021-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
NOS1 | SNV | Missense_Mutation | c.3145N>T | p.Arg1049Trp | p.R1049W | P29475 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NOS1 | SNV | Missense_Mutation | c.2235N>A | p.Phe745Leu | p.F745L | P29475 | protein_coding | deleterious(0.02) | benign(0.222) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NOS1 | SNV | Missense_Mutation | c.934N>A | p.Glu312Lys | p.E312K | P29475 | protein_coding | tolerated(0.29) | benign(0.06) | TCGA-AG-A026-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NOS1 | SNV | Missense_Mutation | c.1550C>T | p.Pro517Leu | p.P517L | P29475 | protein_coding | deleterious(0.01) | benign(0.382) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
NOS1 | SNV | Missense_Mutation | c.1244G>A | p.Arg415Gln | p.R415Q | P29475 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | ibuprofen | IBUPROFEN | 25502615 | |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | BENZODIAZEPINE | BENZODIAZEPINE | 15136793 | |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | SOY PROTEIN | 15328066 | ||
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | PRAZOSIN | PRAZOSIN | 9322222 | |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | DHT | ANDROSTANOLONE | 10725371 | |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | DHEA | PRASTERONE | 16836960 | |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | RETINOIC ACID | 9635256 | ||
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | DEXTRAN SULFATE SODIUM | 15613746,17160477 | ||
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | SALT | VOLANESORSEN SODIUM | 11243307 | |
4842 | NOS1 | DRUGGABLE GENOME, ENZYME | ANTI-INFLAMMATORY DRUGS | 7827327 |
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