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Gene: NOL4L |
Gene summary for NOL4L |
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Gene information | Species | Human | Gene symbol | NOL4L | Gene ID | 140688 |
Gene name | nucleolar protein 4 like | |
Gene Alias | C20orf112 | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087X0N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140688 | NOL4L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.90e-09 | 5.87e-01 | 0.3859 |
140688 | NOL4L | A015-C-203 | Human | Colorectum | FAP | 4.19e-08 | -9.41e-02 | -0.1294 |
140688 | NOL4L | A002-C-201 | Human | Colorectum | FAP | 5.51e-03 | -1.07e-01 | 0.0324 |
140688 | NOL4L | A001-C-108 | Human | Colorectum | FAP | 4.19e-06 | -1.35e-01 | -0.0272 |
140688 | NOL4L | A002-C-205 | Human | Colorectum | FAP | 2.05e-06 | -1.52e-01 | -0.1236 |
140688 | NOL4L | A001-C-104 | Human | Colorectum | FAP | 1.97e-02 | -1.03e-01 | 0.0184 |
140688 | NOL4L | A015-C-006 | Human | Colorectum | FAP | 2.42e-03 | -8.49e-02 | -0.0994 |
140688 | NOL4L | A015-C-106 | Human | Colorectum | FAP | 1.56e-05 | -1.55e-01 | -0.0511 |
140688 | NOL4L | A002-C-114 | Human | Colorectum | FAP | 2.42e-05 | -1.72e-01 | -0.1561 |
140688 | NOL4L | A015-C-104 | Human | Colorectum | FAP | 2.78e-09 | -1.03e-01 | -0.1899 |
140688 | NOL4L | A001-C-014 | Human | Colorectum | FAP | 1.02e-06 | -1.62e-01 | 0.0135 |
140688 | NOL4L | A002-C-016 | Human | Colorectum | FAP | 2.20e-06 | -1.61e-01 | 0.0521 |
140688 | NOL4L | A001-C-203 | Human | Colorectum | FAP | 1.13e-04 | -8.92e-02 | -0.0481 |
140688 | NOL4L | A002-C-116 | Human | Colorectum | FAP | 4.66e-08 | -1.07e-01 | -0.0452 |
140688 | NOL4L | A014-C-008 | Human | Colorectum | FAP | 9.80e-03 | -9.46e-02 | -0.191 |
140688 | NOL4L | A018-E-020 | Human | Colorectum | FAP | 2.32e-05 | -1.51e-01 | -0.2034 |
140688 | NOL4L | F034 | Human | Colorectum | FAP | 6.92e-07 | -1.27e-01 | -0.0665 |
140688 | NOL4L | P2T-E | Human | Esophagus | ESCC | 4.60e-14 | 8.75e-02 | 0.1177 |
140688 | NOL4L | P8T-E | Human | Esophagus | ESCC | 1.85e-30 | 3.80e-01 | 0.0889 |
140688 | NOL4L | P10T-E | Human | Esophagus | ESCC | 6.05e-09 | 2.13e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOL4L | SNV | Missense_Mutation | novel | c.1954C>T | p.Arg652Trp | p.R652W | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NOL4L | deletion | Frame_Shift_Del | novel | c.1790delN | p.Pro597LeufsTer18 | p.P597Lfs*18 | protein_coding | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
NOL4L | deletion | Frame_Shift_Del | c.1128delN | p.Tyr377ThrfsTer20 | p.Y377Tfs*20 | protein_coding | TCGA-BS-A0UL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
NOL4L | deletion | Frame_Shift_Del | c.1128delN | p.Tyr377ThrfsTer20 | p.Y377Tfs*20 | protein_coding | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
NOL4L | deletion | Frame_Shift_Del | c.1128delN | p.Tyr377ThrfsTer20 | p.Y377Tfs*20 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||||
NOL4L | deletion | Frame_Shift_Del | c.1128delN | p.Tyr377ThrfsTer20 | p.Y377Tfs*20 | protein_coding | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD | ||||
NOL4L | deletion | Frame_Shift_Del | c.1128delN | p.Tyr377ThrfsTer20 | p.Y377Tfs*20 | protein_coding | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
NOL4L | SNV | Missense_Mutation | rs369527139 | c.1199G>A | p.Arg400Gln | p.R400Q | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-DD-AAW1-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NOL4L | SNV | Missense_Mutation | novel | c.1264N>T | p.Asp422Tyr | p.D422Y | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR | |
NOL4L | SNV | Missense_Mutation | novel | c.820A>T | p.Asn274Tyr | p.N274Y | protein_coding | deleterious(0.01) | possibly_damaging(0.687) | TCGA-73-4666-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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