![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NCOR2 |
Gene summary for NCOR2 |
![]() |
Gene information | Species | Human | Gene symbol | NCOR2 | Gene ID | 9612 |
Gene name | nuclear receptor corepressor 2 | |
Gene Alias | CTG26 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | C9JE98 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9612 | NCOR2 | CCI_1 | Human | Cervix | CC | 3.15e-04 | 8.64e-01 | 0.528 |
9612 | NCOR2 | CCI_3 | Human | Cervix | CC | 1.54e-07 | 7.68e-01 | 0.516 |
9612 | NCOR2 | L1 | Human | Cervix | CC | 1.84e-02 | -2.45e-01 | 0.0802 |
9612 | NCOR2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.74e-08 | 3.03e-01 | 0.0155 |
9612 | NCOR2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.51e-05 | 5.68e-01 | -0.1808 |
9612 | NCOR2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.15e-07 | 6.43e-01 | -0.0811 |
9612 | NCOR2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.63e-07 | 3.47e-01 | -0.1954 |
9612 | NCOR2 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.31e-06 | 8.97e-01 | -0.2602 |
9612 | NCOR2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.71e-16 | 5.81e-01 | -0.1464 |
9612 | NCOR2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | 4.46e-01 | -0.1001 |
9612 | NCOR2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.79e-12 | 8.98e-01 | -0.059 |
9612 | NCOR2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.27e-02 | 5.21e-01 | -0.0842 |
9612 | NCOR2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.22e-07 | 4.49e-01 | 0.096 |
9612 | NCOR2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.37e-13 | 6.16e-01 | 0.0674 |
9612 | NCOR2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.19e-09 | 8.32e-01 | 0.0112 |
9612 | NCOR2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.58e-10 | 7.42e-01 | 0.0588 |
9612 | NCOR2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.97e-09 | 5.18e-01 | 0.281 |
9612 | NCOR2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.15e-14 | 6.73e-01 | 0.3859 |
9612 | NCOR2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.19e-03 | 5.02e-01 | 0.2585 |
9612 | NCOR2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.36e-07 | 5.01e-01 | 0.3005 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004854510 | Cervix | CC | response to steroid hormone | 74/2311 | 339/18723 | 5.71e-07 | 2.09e-05 | 74 |
GO:00305229 | Cervix | CC | intracellular receptor signaling pathway | 60/2311 | 265/18723 | 1.89e-06 | 5.97e-05 | 60 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:005087810 | Cervix | CC | regulation of body fluid levels | 78/2311 | 379/18723 | 3.20e-06 | 8.77e-05 | 78 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00323556 | Cervix | CC | response to estradiol | 34/2311 | 141/18723 | 8.19e-05 | 1.11e-03 | 34 |
GO:00448492 | Cervix | CC | estrous cycle | 7/2311 | 16/18723 | 1.79e-03 | 1.34e-02 | 7 |
GO:00713839 | Cervix | CC | cellular response to steroid hormone stimulus | 40/2311 | 204/18723 | 1.93e-03 | 1.42e-02 | 40 |
GO:00305188 | Cervix | CC | intracellular steroid hormone receptor signaling pathway | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:00308797 | Cervix | CC | mammary gland development | 28/2311 | 137/18723 | 4.74e-03 | 2.83e-02 | 28 |
GO:00609647 | Cervix | CC | regulation of gene silencing by miRNA | 13/2311 | 49/18723 | 5.34e-03 | 3.10e-02 | 13 |
GO:00305218 | Cervix | CC | androgen receptor signaling pathway | 12/2311 | 44/18723 | 5.76e-03 | 3.30e-02 | 12 |
GO:00351966 | Cervix | CC | production of miRNAs involved in gene silencing by miRNA | 13/2311 | 52/18723 | 9.09e-03 | 4.60e-02 | 13 |
GO:00601476 | Cervix | CC | regulation of posttranscriptional gene silencing | 13/2311 | 52/18723 | 9.09e-03 | 4.60e-02 | 13 |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0043401 | Colorectum | AD | steroid hormone mediated signaling pathway | 51/3918 | 136/18723 | 6.52e-06 | 1.63e-04 | 51 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516920 | Cervix | CC | Epstein-Barr virus infection | 57/1267 | 202/8465 | 7.30e-07 | 7.39e-06 | 4.37e-06 | 57 |
hsa04330 | Cervix | CC | Notch signaling pathway | 17/1267 | 62/8465 | 7.99e-03 | 2.56e-02 | 1.51e-02 | 17 |
hsa05169110 | Cervix | CC | Epstein-Barr virus infection | 57/1267 | 202/8465 | 7.30e-07 | 7.39e-06 | 4.37e-06 | 57 |
hsa043301 | Cervix | CC | Notch signaling pathway | 17/1267 | 62/8465 | 7.99e-03 | 2.56e-02 | 1.51e-02 | 17 |
hsa05169 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa051691 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa043306 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0433013 | Esophagus | ESCC | Notch signaling pathway | 42/4205 | 62/8465 | 2.97e-03 | 7.97e-03 | 4.08e-03 | 42 |
hsa0516921 | Liver | HCC | Epstein-Barr virus infection | 128/4020 | 202/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 128 |
hsa0516931 | Liver | HCC | Epstein-Barr virus infection | 128/4020 | 202/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 128 |
hsa0516916 | Lung | IAC | Epstein-Barr virus infection | 40/1053 | 202/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 40 |
hsa0516917 | Lung | IAC | Epstein-Barr virus infection | 40/1053 | 202/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 40 |
hsa0516928 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa043305 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa05169113 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa0433012 | Oral cavity | OSCC | Notch signaling pathway | 44/3704 | 62/8465 | 1.26e-05 | 5.55e-05 | 2.83e-05 | 44 |
hsa0516929 | Oral cavity | LP | Epstein-Barr virus infection | 106/2418 | 202/8465 | 4.30e-13 | 9.54e-12 | 6.15e-12 | 106 |
hsa0516936 | Oral cavity | LP | Epstein-Barr virus infection | 106/2418 | 202/8465 | 4.30e-13 | 9.54e-12 | 6.15e-12 | 106 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NCOR2 | PERI | Stomach | CAG with IM | TAFA1,RNF31,ISG15, etc. | 6.98e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCOR2 | deletion | Frame_Shift_Del | c.2925delC | p.Ile976SerfsTer87 | p.I976Sfs*87 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
NCOR2 | deletion | Frame_Shift_Del | c.453delN | p.Ser152AlafsTer21 | p.S152Afs*21 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||||
NCOR2 | deletion | Frame_Shift_Del | c.2925delC | p.Ile976SerfsTer87 | p.I976Sfs*87 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | ||||
NCOR2 | deletion | In_Frame_Del | c.5415_5420delNNNNNN | p.Asp1807_Arg1808del | p.D1807_R1808del | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||||
NCOR2 | deletion | Frame_Shift_Del | c.2925delN | p.Ile976SerfsTer87 | p.I976Sfs*87 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||||
NCOR2 | deletion | Frame_Shift_Del | c.2925delN | p.Ile976SerfsTer87 | p.I976Sfs*87 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||||
NCOR2 | deletion | Frame_Shift_Del | rs771862790 | c.3178delC | p.Arg1060ValfsTer3 | p.R1060Vfs*3 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
NCOR2 | deletion | Frame_Shift_Del | c.2925delC | p.Ile976SerfsTer87 | p.I976Sfs*87 | protein_coding | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | ||||
NCOR2 | deletion | Frame_Shift_Del | c.3140delN | p.Pro1047LeufsTer16 | p.P1047Lfs*16 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
NCOR2 | deletion | Frame_Shift_Del | c.751delC | p.Gln251ArgfsTer22 | p.Q251Rfs*22 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9612 | NCOR2 | NUCLEAR HORMONE RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | 9,10-PHENANTHRENEQUINONE | 9,10-PHENANTHRENEQUINONE | ||
9612 | NCOR2 | NUCLEAR HORMONE RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | GNF-PF-2893 | CHEMBL312032 | ||
9612 | NCOR2 | NUCLEAR HORMONE RECEPTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | BENZBROMARONE | BENZBROMARONE |
Page: 1 |