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Gene: NBR1 |
Gene summary for NBR1 |
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Gene information | Species | Human | Gene symbol | NBR1 | Gene ID | 4077 |
Gene name | NBR1 autophagy cargo receptor | |
Gene Alias | 1A1-3B | |
Cytomap | 17q21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q14596 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4077 | NBR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.16e-04 | 3.95e-01 | -0.1808 |
4077 | NBR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.23e-04 | 5.18e-01 | -0.0811 |
4077 | NBR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.07e-12 | 6.98e-01 | -0.1088 |
4077 | NBR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-36 | 9.78e-01 | -0.1954 |
4077 | NBR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.19e-05 | 8.71e-01 | -0.2602 |
4077 | NBR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.41e-05 | 5.30e-01 | -0.1526 |
4077 | NBR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.30e-09 | 5.45e-01 | -0.1464 |
4077 | NBR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.20e-11 | 5.31e-01 | -0.1001 |
4077 | NBR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.47e-06 | 5.35e-01 | -0.059 |
4077 | NBR1 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.67e-03 | 5.44e-01 | -0.0842 |
4077 | NBR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.46e-04 | 3.84e-01 | 0.096 |
4077 | NBR1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.26e-02 | 6.53e-01 | 0.0446 |
4077 | NBR1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.05e-02 | 6.04e-01 | 0.0131 |
4077 | NBR1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.28e-02 | 4.46e-01 | -0.0177 |
4077 | NBR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.63e-04 | 3.64e-01 | 0.0674 |
4077 | NBR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.62e-11 | 6.32e-01 | 0.294 |
4077 | NBR1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.11e-03 | 9.86e-01 | 0.3487 |
4077 | NBR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.18e-14 | 8.87e-01 | 0.281 |
4077 | NBR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.75e-14 | 6.98e-01 | 0.3859 |
4077 | NBR1 | A015-C-203 | Human | Colorectum | FAP | 6.50e-09 | -7.09e-02 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0070302 | Colorectum | AD | regulation of stress-activated protein kinase signaling cascade | 58/3918 | 195/18723 | 2.21e-03 | 1.74e-02 | 58 |
GO:0032872 | Colorectum | AD | regulation of stress-activated MAPK cascade | 57/3918 | 192/18723 | 2.51e-03 | 1.92e-02 | 57 |
GO:0001503 | Colorectum | AD | ossification | 106/3918 | 408/18723 | 7.68e-03 | 4.64e-02 | 106 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00016491 | Colorectum | SER | osteoblast differentiation | 56/2897 | 229/18723 | 2.49e-04 | 4.21e-03 | 56 |
GO:00310981 | Colorectum | SER | stress-activated protein kinase signaling cascade | 54/2897 | 247/18723 | 4.65e-03 | 3.67e-02 | 54 |
GO:00514031 | Colorectum | SER | stress-activated MAPK cascade | 52/2897 | 239/18723 | 5.96e-03 | 4.35e-02 | 52 |
GO:00015031 | Colorectum | SER | ossification | 82/2897 | 408/18723 | 6.76e-03 | 4.78e-02 | 82 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00016492 | Colorectum | MSS | osteoblast differentiation | 64/3467 | 229/18723 | 2.91e-04 | 3.83e-03 | 64 |
GO:00310982 | Colorectum | MSS | stress-activated protein kinase signaling cascade | 67/3467 | 247/18723 | 5.28e-04 | 5.99e-03 | 67 |
GO:00514032 | Colorectum | MSS | stress-activated MAPK cascade | 65/3467 | 239/18723 | 5.87e-04 | 6.49e-03 | 65 |
GO:00703021 | Colorectum | MSS | regulation of stress-activated protein kinase signaling cascade | 52/3467 | 195/18723 | 3.07e-03 | 2.34e-02 | 52 |
GO:00328721 | Colorectum | MSS | regulation of stress-activated MAPK cascade | 51/3467 | 192/18723 | 3.65e-03 | 2.69e-02 | 51 |
GO:00015032 | Colorectum | MSS | ossification | 96/3467 | 408/18723 | 6.09e-03 | 4.07e-02 | 96 |
GO:00162363 | Colorectum | FAP | macroautophagy | 70/2622 | 291/18723 | 2.73e-06 | 1.02e-04 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04137 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041371 | Colorectum | AD | Mitophagy - animal | 29/2092 | 72/8465 | 2.49e-03 | 1.35e-02 | 8.59e-03 | 29 |
hsa041372 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041373 | Colorectum | SER | Mitophagy - animal | 22/1580 | 72/8465 | 9.93e-03 | 4.78e-02 | 3.47e-02 | 22 |
hsa041374 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa041375 | Colorectum | MSS | Mitophagy - animal | 27/1875 | 72/8465 | 2.17e-03 | 1.10e-02 | 6.76e-03 | 27 |
hsa041376 | Colorectum | MSI-H | Mitophagy - animal | 16/797 | 72/8465 | 8.73e-04 | 1.01e-02 | 8.48e-03 | 16 |
hsa041377 | Colorectum | MSI-H | Mitophagy - animal | 16/797 | 72/8465 | 8.73e-04 | 1.01e-02 | 8.48e-03 | 16 |
hsa041378 | Colorectum | FAP | Mitophagy - animal | 20/1404 | 72/8465 | 1.14e-02 | 3.92e-02 | 2.38e-02 | 20 |
hsa041379 | Colorectum | FAP | Mitophagy - animal | 20/1404 | 72/8465 | 1.14e-02 | 3.92e-02 | 2.38e-02 | 20 |
hsa0413730 | Esophagus | HGIN | Mitophagy - animal | 23/1383 | 72/8465 | 7.69e-04 | 7.59e-03 | 6.03e-03 | 23 |
hsa04137113 | Esophagus | HGIN | Mitophagy - animal | 23/1383 | 72/8465 | 7.69e-04 | 7.59e-03 | 6.03e-03 | 23 |
hsa04137210 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413738 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413721 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413731 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413728 | Oral cavity | OSCC | Mitophagy - animal | 58/3704 | 72/8465 | 1.48e-10 | 2.07e-09 | 1.05e-09 | 58 |
hsa04137112 | Oral cavity | OSCC | Mitophagy - animal | 58/3704 | 72/8465 | 1.48e-10 | 2.07e-09 | 1.05e-09 | 58 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBR1 | insertion | Frame_Shift_Ins | novel | c.1285_1286insC | p.Val429AlafsTer60 | p.V429Afs*60 | Q14596 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NBR1 | insertion | In_Frame_Ins | novel | c.1287_1288insAGTCACTTGCTG | p.Val429_Leu430insSerHisLeuLeu | p.V429_L430insSHLL | Q14596 | protein_coding | TCGA-A5-A0R9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NBR1 | insertion | Frame_Shift_Ins | novel | c.2355_2356insT | p.Gly786TrpfsTer12 | p.G786Wfs*12 | Q14596 | protein_coding | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NBR1 | deletion | Frame_Shift_Del | rs34660735 | c.2232delN | p.Leu746TrpfsTer50 | p.L746Wfs*50 | Q14596 | protein_coding | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NBR1 | SNV | Missense_Mutation | c.1387C>T | p.His463Tyr | p.H463Y | Q14596 | protein_coding | deleterious(0) | possibly_damaging(0.703) | TCGA-BC-A217-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBR1 | SNV | Missense_Mutation | c.1936N>G | p.Thr646Ala | p.T646A | Q14596 | protein_coding | tolerated(0.06) | possibly_damaging(0.625) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NBR1 | SNV | Missense_Mutation | novel | c.1702N>G | p.Ile568Val | p.I568V | Q14596 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DD-AACP-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NBR1 | SNV | Missense_Mutation | c.486N>T | p.Arg162Ser | p.R162S | Q14596 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
NBR1 | SNV | Missense_Mutation | c.2437N>C | p.Glu813Gln | p.E813Q | Q14596 | protein_coding | tolerated(0.13) | possibly_damaging(0.732) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
NBR1 | SNV | Missense_Mutation | novel | c.1630N>A | p.Glu544Lys | p.E544K | Q14596 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-ZS-A9CF-02 | Liver | NA | NA | NA | NA | NA | NA | NA |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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