![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NBPF14 |
Gene summary for NBPF14 |
![]() |
Gene information | Species | Human | Gene symbol | NBPF14 | Gene ID | 25832 |
Gene name | NBPF member 14 | |
Gene Alias | DJ328E19.C1.1 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WZJ2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25832 | NBPF14 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.72e-15 | 1.10e+00 | -0.1954 |
25832 | NBPF14 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.60e-03 | 5.81e-01 | -0.1526 |
25832 | NBPF14 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.54e-04 | 4.60e-01 | -0.1001 |
25832 | NBPF14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.01e-02 | 3.58e-01 | -0.059 |
25832 | NBPF14 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.22e-03 | 2.45e-01 | 0.0674 |
25832 | NBPF14 | A015-C-203 | Human | Colorectum | FAP | 6.95e-04 | 1.41e-01 | -0.1294 |
25832 | NBPF14 | A015-C-104 | Human | Colorectum | FAP | 2.00e-03 | 5.02e-02 | -0.1899 |
25832 | NBPF14 | A002-C-116 | Human | Colorectum | FAP | 7.89e-06 | -9.20e-02 | -0.0452 |
25832 | NBPF14 | CRC-1-8810 | Human | Colorectum | CRC | 2.09e-02 | -1.58e-01 | 0.6257 |
25832 | NBPF14 | CRC-3-11773 | Human | Colorectum | CRC | 3.35e-02 | -1.76e-01 | 0.2564 |
25832 | NBPF14 | LZE4T | Human | Esophagus | ESCC | 2.53e-02 | 9.40e-02 | 0.0811 |
25832 | NBPF14 | LZE5T | Human | Esophagus | ESCC | 3.95e-02 | 3.57e-01 | 0.0514 |
25832 | NBPF14 | LZE20T | Human | Esophagus | ESCC | 1.27e-03 | 7.27e-02 | 0.0662 |
25832 | NBPF14 | LZE24T | Human | Esophagus | ESCC | 4.13e-04 | 1.54e-01 | 0.0596 |
25832 | NBPF14 | P1T-E | Human | Esophagus | ESCC | 1.81e-28 | 1.37e+00 | 0.0875 |
25832 | NBPF14 | P2T-E | Human | Esophagus | ESCC | 1.26e-16 | 3.04e-01 | 0.1177 |
25832 | NBPF14 | P5T-E | Human | Esophagus | ESCC | 3.26e-23 | 4.52e-01 | 0.1327 |
25832 | NBPF14 | P8T-E | Human | Esophagus | ESCC | 5.04e-11 | 1.49e-01 | 0.0889 |
25832 | NBPF14 | P9T-E | Human | Esophagus | ESCC | 2.45e-11 | 1.89e-01 | 0.1131 |
25832 | NBPF14 | P10T-E | Human | Esophagus | ESCC | 2.05e-18 | 3.42e-01 | 0.116 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF14 | SNV | Missense_Mutation | novel | c.451G>T | p.Gly151Trp | p.G151W | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.397N>T | p.Pro133Ser | p.P133S | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.7948C>T | p.Leu2650Phe | p.L2650F | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NBPF14 | SNV | Missense_Mutation | novel | c.99G>T | p.Gln33His | p.Q33H | protein_coding | tolerated(0.06) | benign(0.132) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NBPF14 | insertion | Frame_Shift_Ins | novel | c.4584dupA | p.Gly1529ArgfsTer3 | p.G1529Rfs*3 | protein_coding | TCGA-66-2770-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
NBPF14 | SNV | Missense_Mutation | novel | c.1357N>A | p.Val453Met | p.V453M | protein_coding | deleterious(0.02) | probably_damaging(0.972) | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.8593G>C | p.Gly2865Arg | p.G2865R | protein_coding | tolerated(0.16) | probably_damaging(0.999) | TCGA-CV-5441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.220N>A | p.Glu74Lys | p.E74K | protein_coding | deleterious(0.01) | possibly_damaging(0.62) | TCGA-IQ-7630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | CR | |
NBPF14 | SNV | Missense_Mutation | novel | c.4630N>G | p.Pro1544Ala | p.P1544A | protein_coding | tolerated(0.5) | benign(0.015) | TCGA-IQ-A6SH-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.4723A>C | p.Met1575Leu | p.M1575L | protein_coding | tolerated(0.19) | benign(0) | TCGA-UF-A7JF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |