![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NASP |
Gene summary for NASP |
![]() |
Gene information | Species | Human | Gene symbol | NASP | Gene ID | 4678 |
Gene name | nuclear autoantigenic sperm protein | |
Gene Alias | FLB7527 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P49321 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4678 | NASP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.33e-03 | 4.86e-01 | -0.059 |
4678 | NASP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.94e-06 | 4.24e-01 | 0.294 |
4678 | NASP | A015-C-203 | Human | Colorectum | FAP | 4.40e-03 | 1.11e-01 | -0.1294 |
4678 | NASP | A002-C-205 | Human | Colorectum | FAP | 1.74e-02 | 2.18e-01 | -0.1236 |
4678 | NASP | A015-C-104 | Human | Colorectum | FAP | 2.15e-04 | 1.20e-01 | -0.1899 |
4678 | NASP | A002-C-016 | Human | Colorectum | FAP | 3.61e-02 | 3.13e-02 | 0.0521 |
4678 | NASP | A002-C-116 | Human | Colorectum | FAP | 1.84e-04 | 8.74e-02 | -0.0452 |
4678 | NASP | F034 | Human | Colorectum | FAP | 3.38e-03 | 2.13e-01 | -0.0665 |
4678 | NASP | AEH-subject1 | Human | Endometrium | AEH | 1.98e-03 | 1.99e-01 | -0.3059 |
4678 | NASP | AEH-subject2 | Human | Endometrium | AEH | 1.71e-05 | -1.17e-01 | -0.2525 |
4678 | NASP | AEH-subject3 | Human | Endometrium | AEH | 5.48e-04 | -2.11e-02 | -0.2576 |
4678 | NASP | AEH-subject5 | Human | Endometrium | AEH | 6.85e-05 | -2.09e-01 | -0.2953 |
4678 | NASP | EEC-subject1 | Human | Endometrium | EEC | 5.27e-05 | -3.62e-02 | -0.2682 |
4678 | NASP | EEC-subject3 | Human | Endometrium | EEC | 3.53e-20 | -2.58e-01 | -0.2525 |
4678 | NASP | EEC-subject5 | Human | Endometrium | EEC | 2.13e-02 | -2.02e-01 | -0.249 |
4678 | NASP | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 7.69e-30 | -2.05e-01 | -0.1869 |
4678 | NASP | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.06e-21 | -3.00e-01 | -0.1875 |
4678 | NASP | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.94e-28 | -2.64e-01 | -0.1883 |
4678 | NASP | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 7.07e-24 | -1.02e-02 | -0.1934 |
4678 | NASP | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.11e-42 | -2.60e-01 | -0.1917 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
GO:00017013 | Colorectum | FAP | in utero embryonic development | 81/2622 | 367/18723 | 1.58e-05 | 4.10e-04 | 81 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:19016544 | Colorectum | FAP | response to ketone | 45/2622 | 194/18723 | 3.67e-04 | 4.63e-03 | 45 |
GO:00614583 | Colorectum | FAP | reproductive system development | 85/2622 | 427/18723 | 4.30e-04 | 5.13e-03 | 85 |
GO:00486083 | Colorectum | FAP | reproductive structure development | 84/2622 | 424/18723 | 5.40e-04 | 6.10e-03 | 84 |
GO:00614589 | Endometrium | AEH | reproductive system development | 88/2100 | 427/18723 | 9.50e-09 | 6.41e-07 | 88 |
GO:00486089 | Endometrium | AEH | reproductive structure development | 87/2100 | 424/18723 | 1.43e-08 | 9.12e-07 | 87 |
GO:00017019 | Endometrium | AEH | in utero embryonic development | 73/2100 | 367/18723 | 7.18e-07 | 2.63e-05 | 73 |
GO:190165415 | Endometrium | AEH | response to ketone | 45/2100 | 194/18723 | 1.48e-06 | 4.69e-05 | 45 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NASP | SNV | Missense_Mutation | novel | c.448N>A | p.Ala150Thr | p.A150T | P49321 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |