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Gene: MOSPD2 |
Gene summary for MOSPD2 |
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Gene information | Species | Human | Gene symbol | MOSPD2 | Gene ID | 158747 |
Gene name | motile sperm domain containing 2 | |
Gene Alias | MOSPD2 | |
Cytomap | Xp22.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8NHP6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158747 | MOSPD2 | HCC1_Meng | Human | Liver | HCC | 3.01e-30 | 7.45e-02 | 0.0246 |
158747 | MOSPD2 | HCC2_Meng | Human | Liver | HCC | 8.54e-08 | 4.63e-02 | 0.0107 |
158747 | MOSPD2 | HCC2 | Human | Liver | HCC | 3.54e-06 | 2.33e+00 | 0.5341 |
158747 | MOSPD2 | S015 | Human | Liver | HCC | 4.35e-03 | 2.21e-01 | 0.2375 |
158747 | MOSPD2 | S027 | Human | Liver | HCC | 1.34e-09 | 5.68e-01 | 0.2446 |
158747 | MOSPD2 | S028 | Human | Liver | HCC | 1.53e-14 | 5.24e-01 | 0.2503 |
158747 | MOSPD2 | S029 | Human | Liver | HCC | 1.06e-14 | 5.45e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MOSPD2 | SNV | Missense_Mutation | novel | c.223A>C | p.Ile75Leu | p.I75L | Q8NHP6 | protein_coding | tolerated(0.08) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
MOSPD2 | deletion | Frame_Shift_Del | novel | c.1183delN | p.Gly396ValfsTer2 | p.G396Vfs*2 | Q8NHP6 | protein_coding | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MOSPD2 | insertion | Frame_Shift_Ins | novel | c.428_429insCAAGACTTATGGCATTATAATATTATTAT | p.Lys143AsnfsTer13 | p.K143Nfs*13 | Q8NHP6 | protein_coding | TCGA-HF-7133-01 | Stomach | stomach adenocarcinoma | Female | Unknown | III/IV | Chemotherapy | epirubicin | SD | ||
MOSPD2 | insertion | Frame_Shift_Ins | novel | c.989_990insAA | p.Ser331ThrfsTer20 | p.S331Tfs*20 | Q8NHP6 | protein_coding | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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