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Gene: MGA |
Gene summary for MGA |
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Gene information | Species | Human | Gene symbol | MGA | Gene ID | 23269 |
Gene name | MAX dimerization protein MGA | |
Gene Alias | MAD5 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0001708 | UniProtAcc | B9EGR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23269 | MGA | CCI_2 | Human | Cervix | CC | 6.89e-19 | 1.56e+00 | 0.5249 |
23269 | MGA | CCI_3 | Human | Cervix | CC | 9.22e-05 | 6.23e-01 | 0.516 |
23269 | MGA | LZE4T | Human | Esophagus | ESCC | 2.75e-09 | 2.77e-01 | 0.0811 |
23269 | MGA | LZE7T | Human | Esophagus | ESCC | 1.98e-10 | 6.15e-01 | 0.0667 |
23269 | MGA | LZE8T | Human | Esophagus | ESCC | 3.34e-02 | 6.30e-02 | 0.067 |
23269 | MGA | LZE24T | Human | Esophagus | ESCC | 1.35e-13 | 2.65e-01 | 0.0596 |
23269 | MGA | LZE6T | Human | Esophagus | ESCC | 4.02e-04 | 1.30e-01 | 0.0845 |
23269 | MGA | P1T-E | Human | Esophagus | ESCC | 9.75e-07 | 3.57e-01 | 0.0875 |
23269 | MGA | P2T-E | Human | Esophagus | ESCC | 1.63e-21 | 2.74e-01 | 0.1177 |
23269 | MGA | P4T-E | Human | Esophagus | ESCC | 4.87e-05 | 1.58e-01 | 0.1323 |
23269 | MGA | P5T-E | Human | Esophagus | ESCC | 2.19e-12 | 1.42e-01 | 0.1327 |
23269 | MGA | P8T-E | Human | Esophagus | ESCC | 1.83e-26 | 4.24e-01 | 0.0889 |
23269 | MGA | P9T-E | Human | Esophagus | ESCC | 2.53e-08 | 2.07e-01 | 0.1131 |
23269 | MGA | P10T-E | Human | Esophagus | ESCC | 1.71e-31 | 5.82e-01 | 0.116 |
23269 | MGA | P11T-E | Human | Esophagus | ESCC | 5.49e-07 | 2.50e-01 | 0.1426 |
23269 | MGA | P12T-E | Human | Esophagus | ESCC | 3.21e-20 | 3.60e-01 | 0.1122 |
23269 | MGA | P15T-E | Human | Esophagus | ESCC | 2.19e-19 | 4.18e-01 | 0.1149 |
23269 | MGA | P16T-E | Human | Esophagus | ESCC | 7.43e-17 | 2.57e-01 | 0.1153 |
23269 | MGA | P19T-E | Human | Esophagus | ESCC | 6.57e-03 | 1.92e-01 | 0.1662 |
23269 | MGA | P20T-E | Human | Esophagus | ESCC | 1.11e-09 | 1.13e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00329865 | Breast | Precancer | protein-DNA complex disassembly | 6/1080 | 20/18723 | 6.99e-04 | 8.43e-03 | 6 |
GO:00075694 | Breast | Precancer | cell aging | 17/1080 | 132/18723 | 1.55e-03 | 1.59e-02 | 17 |
GO:00903423 | Breast | Precancer | regulation of cell aging | 10/1080 | 61/18723 | 2.40e-03 | 2.21e-02 | 10 |
GO:000756813 | Breast | IDC | aging | 52/1434 | 339/18723 | 1.14e-06 | 5.10e-05 | 52 |
GO:00096157 | Breast | IDC | response to virus | 47/1434 | 367/18723 | 3.53e-04 | 5.16e-03 | 47 |
GO:003298612 | Breast | IDC | protein-DNA complex disassembly | 6/1434 | 20/18723 | 3.03e-03 | 2.60e-02 | 6 |
GO:000756912 | Breast | IDC | cell aging | 19/1434 | 132/18723 | 5.63e-03 | 4.08e-02 | 19 |
GO:00903421 | Breast | IDC | regulation of cell aging | 11/1434 | 61/18723 | 6.10e-03 | 4.36e-02 | 11 |
GO:000756823 | Breast | DCIS | aging | 50/1390 | 339/18723 | 2.38e-06 | 8.46e-05 | 50 |
GO:000961512 | Breast | DCIS | response to virus | 45/1390 | 367/18723 | 6.16e-04 | 7.82e-03 | 45 |
GO:003298621 | Breast | DCIS | protein-DNA complex disassembly | 6/1390 | 20/18723 | 2.59e-03 | 2.30e-02 | 6 |
GO:000756921 | Breast | DCIS | cell aging | 19/1390 | 132/18723 | 4.03e-03 | 3.20e-02 | 19 |
GO:00903422 | Breast | DCIS | regulation of cell aging | 11/1390 | 61/18723 | 4.84e-03 | 3.67e-02 | 11 |
GO:002241113 | Breast | DCIS | cellular component disassembly | 48/1390 | 443/18723 | 5.35e-03 | 3.92e-02 | 48 |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGA | SNV | Missense_Mutation | rs779811318 | c.7303N>T | p.Arg2435Trp | p.R2435W | Q8IWI9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGA | SNV | Missense_Mutation | c.748G>T | p.Asp250Tyr | p.D250Y | Q8IWI9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MGA | SNV | Missense_Mutation | rs376715603 | c.4139G>A | p.Arg1380Gln | p.R1380Q | Q8IWI9 | protein_coding | tolerated(0.07) | possibly_damaging(0.543) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MGA | SNV | Missense_Mutation | c.6301T>G | p.Leu2101Val | p.L2101V | Q8IWI9 | protein_coding | tolerated_low_confidence(0.83) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MGA | SNV | Missense_Mutation | novel | c.8701N>A | p.Leu2901Ile | p.L2901I | Q8IWI9 | protein_coding | deleterious(0.01) | possibly_damaging(0.875) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MGA | SNV | Missense_Mutation | c.7126T>C | p.Ser2376Pro | p.S2376P | Q8IWI9 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MGA | SNV | Missense_Mutation | rs374431638 | c.8135N>T | p.Thr2712Met | p.T2712M | Q8IWI9 | protein_coding | tolerated_low_confidence(0.05) | benign(0.212) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MGA | SNV | Missense_Mutation | rs769019565 | c.4399N>T | p.Arg1467Cys | p.R1467C | Q8IWI9 | protein_coding | tolerated(0.15) | probably_damaging(0.925) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MGA | SNV | Missense_Mutation | novel | c.3719N>A | p.Arg1240Gln | p.R1240Q | Q8IWI9 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MGA | SNV | Missense_Mutation | novel | c.4186N>G | p.Lys1396Glu | p.K1396E | Q8IWI9 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23269 | MGA | TRANSCRIPTION FACTOR | inhibitor | CHEMBL1561 | MIGLITOL | |
23269 | MGA | TRANSCRIPTION FACTOR | inhibitor | CHEMBL1566 | ACARBOSE |
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