![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MEGF9 |
Gene summary for MEGF9 |
![]() |
Gene information | Species | Human | Gene symbol | MEGF9 | Gene ID | 1955 |
Gene name | multiple EGF like domains 9 | |
Gene Alias | EGFL5 | |
Cytomap | 9q33.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9H1U4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1955 | MEGF9 | LZE4T | Human | Esophagus | ESCC | 2.58e-05 | 2.66e-01 | 0.0811 |
1955 | MEGF9 | LZE7T | Human | Esophagus | ESCC | 8.94e-04 | 2.39e-01 | 0.0667 |
1955 | MEGF9 | LZE20T | Human | Esophagus | ESCC | 6.73e-05 | 9.66e-02 | 0.0662 |
1955 | MEGF9 | LZE24T | Human | Esophagus | ESCC | 8.03e-11 | 1.47e-01 | 0.0596 |
1955 | MEGF9 | P2T-E | Human | Esophagus | ESCC | 7.12e-23 | 4.18e-01 | 0.1177 |
1955 | MEGF9 | P4T-E | Human | Esophagus | ESCC | 3.36e-16 | 2.55e-01 | 0.1323 |
1955 | MEGF9 | P5T-E | Human | Esophagus | ESCC | 2.51e-03 | -2.17e-03 | 0.1327 |
1955 | MEGF9 | P8T-E | Human | Esophagus | ESCC | 1.65e-03 | 9.38e-02 | 0.0889 |
1955 | MEGF9 | P9T-E | Human | Esophagus | ESCC | 2.23e-12 | 2.89e-01 | 0.1131 |
1955 | MEGF9 | P10T-E | Human | Esophagus | ESCC | 1.21e-15 | 1.79e-01 | 0.116 |
1955 | MEGF9 | P11T-E | Human | Esophagus | ESCC | 1.88e-04 | 2.01e-01 | 0.1426 |
1955 | MEGF9 | P12T-E | Human | Esophagus | ESCC | 2.68e-16 | 2.70e-01 | 0.1122 |
1955 | MEGF9 | P15T-E | Human | Esophagus | ESCC | 2.99e-10 | 2.92e-01 | 0.1149 |
1955 | MEGF9 | P16T-E | Human | Esophagus | ESCC | 8.97e-10 | 1.57e-01 | 0.1153 |
1955 | MEGF9 | P20T-E | Human | Esophagus | ESCC | 1.01e-04 | 2.83e-03 | 0.1124 |
1955 | MEGF9 | P21T-E | Human | Esophagus | ESCC | 1.39e-04 | 8.46e-02 | 0.1617 |
1955 | MEGF9 | P22T-E | Human | Esophagus | ESCC | 3.90e-03 | -1.57e-02 | 0.1236 |
1955 | MEGF9 | P23T-E | Human | Esophagus | ESCC | 9.75e-03 | 1.68e-02 | 0.108 |
1955 | MEGF9 | P24T-E | Human | Esophagus | ESCC | 8.32e-06 | 2.70e-02 | 0.1287 |
1955 | MEGF9 | P26T-E | Human | Esophagus | ESCC | 2.68e-15 | 1.65e-01 | 0.1276 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158919 | Esophagus | ESCC | cell-substrate adhesion | 221/8552 | 363/18723 | 3.06e-09 | 6.62e-08 | 221 |
GO:003444620 | Esophagus | ESCC | substrate adhesion-dependent cell spreading | 65/8552 | 108/18723 | 1.67e-03 | 7.72e-03 | 65 |
GO:00315896 | Liver | NAFLD | cell-substrate adhesion | 65/1882 | 363/18723 | 2.84e-06 | 1.18e-04 | 65 |
GO:00344467 | Liver | NAFLD | substrate adhesion-dependent cell spreading | 25/1882 | 108/18723 | 5.41e-05 | 1.23e-03 | 25 |
GO:003158912 | Liver | Cirrhotic | cell-substrate adhesion | 128/4634 | 363/18723 | 4.10e-06 | 6.90e-05 | 128 |
GO:003444612 | Liver | Cirrhotic | substrate adhesion-dependent cell spreading | 47/4634 | 108/18723 | 1.48e-05 | 2.05e-04 | 47 |
GO:003444622 | Liver | HCC | substrate adhesion-dependent cell spreading | 67/7958 | 108/18723 | 3.24e-05 | 3.28e-04 | 67 |
GO:003158922 | Liver | HCC | cell-substrate adhesion | 188/7958 | 363/18723 | 2.00e-04 | 1.55e-03 | 188 |
GO:00315897 | Lung | IAC | cell-substrate adhesion | 85/2061 | 363/18723 | 8.57e-12 | 4.27e-09 | 85 |
GO:00344468 | Lung | IAC | substrate adhesion-dependent cell spreading | 21/2061 | 108/18723 | 6.67e-03 | 4.67e-02 | 21 |
GO:003158913 | Lung | AIS | cell-substrate adhesion | 80/1849 | 363/18723 | 3.80e-12 | 3.16e-09 | 80 |
GO:003444613 | Lung | AIS | substrate adhesion-dependent cell spreading | 21/1849 | 108/18723 | 1.86e-03 | 2.07e-02 | 21 |
GO:003444625 | Thyroid | HT | substrate adhesion-dependent cell spreading | 19/1272 | 108/18723 | 1.12e-04 | 1.84e-03 | 19 |
GO:003158927 | Thyroid | HT | cell-substrate adhesion | 41/1272 | 363/18723 | 9.54e-04 | 9.83e-03 | 41 |
GO:0031589111 | Thyroid | PTC | cell-substrate adhesion | 169/5968 | 363/18723 | 2.73e-09 | 7.57e-08 | 169 |
GO:0034446111 | Thyroid | PTC | substrate adhesion-dependent cell spreading | 58/5968 | 108/18723 | 2.07e-06 | 2.82e-05 | 58 |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:003444634 | Thyroid | ATC | substrate adhesion-dependent cell spreading | 64/6293 | 108/18723 | 3.98e-08 | 7.31e-07 | 64 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MEGF9 | SNV | Missense_Mutation | c.1724N>T | p.Ser575Leu | p.S575L | Q9H1U4 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MEGF9 | SNV | Missense_Mutation | novel | c.358C>T | p.Leu120Phe | p.L120F | Q9H1U4 | protein_coding | tolerated_low_confidence(0.07) | benign(0.11) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MEGF9 | SNV | Missense_Mutation | novel | c.1648N>C | p.Phe550Leu | p.F550L | Q9H1U4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MEGF9 | deletion | Frame_Shift_Del | novel | c.1538_1539delTT | p.Phe513Ter | p.F513* | Q9H1U4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
MEGF9 | insertion | Frame_Shift_Ins | novel | c.1537_1538insCCCGA | p.Phe513SerfsTer8 | p.F513Sfs*8 | Q9H1U4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
MEGF9 | insertion | Frame_Shift_Ins | novel | c.1424_1425insATATACA | p.Pro476TyrfsTer9 | p.P476Yfs*9 | Q9H1U4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |