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Gene: MED16 |
Gene summary for MED16 |
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Gene information | Species | Human | Gene symbol | MED16 | Gene ID | 10025 |
Gene name | mediator complex subunit 16 | |
Gene Alias | DRIP92 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y2X0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10025 | MED16 | LZE4T | Human | Esophagus | ESCC | 3.13e-08 | 1.36e-01 | 0.0811 |
10025 | MED16 | LZE7T | Human | Esophagus | ESCC | 6.04e-04 | 1.10e-01 | 0.0667 |
10025 | MED16 | LZE8T | Human | Esophagus | ESCC | 9.57e-04 | 8.91e-02 | 0.067 |
10025 | MED16 | LZE20T | Human | Esophagus | ESCC | 2.04e-04 | 1.63e-01 | 0.0662 |
10025 | MED16 | LZE24T | Human | Esophagus | ESCC | 1.23e-18 | 3.60e-01 | 0.0596 |
10025 | MED16 | LZE22D3 | Human | Esophagus | HGIN | 9.37e-04 | 5.85e-01 | 0.0653 |
10025 | MED16 | LZE21T | Human | Esophagus | ESCC | 1.94e-04 | 3.83e-01 | 0.0655 |
10025 | MED16 | P1T-E | Human | Esophagus | ESCC | 7.85e-11 | 4.74e-01 | 0.0875 |
10025 | MED16 | P2T-E | Human | Esophagus | ESCC | 7.13e-16 | 2.86e-01 | 0.1177 |
10025 | MED16 | P4T-E | Human | Esophagus | ESCC | 4.97e-17 | 2.55e-01 | 0.1323 |
10025 | MED16 | P5T-E | Human | Esophagus | ESCC | 1.78e-14 | 1.12e-01 | 0.1327 |
10025 | MED16 | P8T-E | Human | Esophagus | ESCC | 4.03e-13 | 1.65e-01 | 0.0889 |
10025 | MED16 | P9T-E | Human | Esophagus | ESCC | 1.09e-16 | 3.46e-01 | 0.1131 |
10025 | MED16 | P10T-E | Human | Esophagus | ESCC | 2.50e-21 | 2.58e-01 | 0.116 |
10025 | MED16 | P11T-E | Human | Esophagus | ESCC | 9.95e-13 | 3.86e-01 | 0.1426 |
10025 | MED16 | P12T-E | Human | Esophagus | ESCC | 2.66e-28 | 4.61e-01 | 0.1122 |
10025 | MED16 | P15T-E | Human | Esophagus | ESCC | 9.90e-22 | 4.14e-01 | 0.1149 |
10025 | MED16 | P16T-E | Human | Esophagus | ESCC | 2.22e-18 | 3.08e-01 | 0.1153 |
10025 | MED16 | P17T-E | Human | Esophagus | ESCC | 9.65e-20 | 6.81e-01 | 0.1278 |
10025 | MED16 | P19T-E | Human | Esophagus | ESCC | 6.96e-12 | 6.55e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063523 | Esophagus | HGIN | DNA-templated transcription, initiation | 30/2587 | 130/18723 | 2.86e-03 | 2.79e-02 | 30 |
GO:20001424 | Esophagus | HGIN | regulation of DNA-templated transcription, initiation | 12/2587 | 40/18723 | 6.22e-03 | 4.95e-02 | 12 |
GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00602603 | Esophagus | ESCC | regulation of transcription initiation from RNA polymerase II promoter | 25/8552 | 33/18723 | 4.30e-04 | 2.43e-03 | 25 |
GO:200014212 | Esophagus | ESCC | regulation of DNA-templated transcription, initiation | 29/8552 | 40/18723 | 5.32e-04 | 2.93e-03 | 29 |
GO:20001443 | Esophagus | ESCC | positive regulation of DNA-templated transcription, initiation | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:00063671 | Liver | HCC | transcription initiation from RNA polymerase II promoter | 52/7958 | 77/18723 | 7.87e-06 | 9.27e-05 | 52 |
GO:0006352 | Liver | HCC | DNA-templated transcription, initiation | 78/7958 | 130/18723 | 4.19e-05 | 4.11e-04 | 78 |
GO:20001421 | Liver | HCC | regulation of DNA-templated transcription, initiation | 28/7958 | 40/18723 | 4.01e-04 | 2.71e-03 | 28 |
GO:00602601 | Liver | HCC | regulation of transcription initiation from RNA polymerase II promoter | 24/7958 | 33/18723 | 4.24e-04 | 2.85e-03 | 24 |
GO:2000144 | Liver | HCC | positive regulation of DNA-templated transcription, initiation | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
GO:0060261 | Liver | HCC | positive regulation of transcription initiation from RNA polymerase II promoter | 17/7958 | 25/18723 | 8.94e-03 | 3.45e-02 | 17 |
GO:00063522 | Oral cavity | OSCC | DNA-templated transcription, initiation | 74/7305 | 130/18723 | 2.56e-05 | 2.39e-04 | 74 |
GO:00063672 | Oral cavity | OSCC | transcription initiation from RNA polymerase II promoter | 46/7305 | 77/18723 | 1.82e-04 | 1.24e-03 | 46 |
GO:20001423 | Oral cavity | OSCC | regulation of DNA-templated transcription, initiation | 26/7305 | 40/18723 | 7.79e-04 | 4.23e-03 | 26 |
GO:20001442 | Oral cavity | OSCC | positive regulation of DNA-templated transcription, initiation | 21/7305 | 31/18723 | 1.13e-03 | 5.75e-03 | 21 |
GO:00602602 | Oral cavity | OSCC | regulation of transcription initiation from RNA polymerase II promoter | 21/7305 | 33/18723 | 3.63e-03 | 1.51e-02 | 21 |
GO:00602611 | Oral cavity | OSCC | positive regulation of transcription initiation from RNA polymerase II promoter | 16/7305 | 25/18723 | 1.00e-02 | 3.49e-02 | 16 |
GO:00063675 | Thyroid | PTC | transcription initiation from RNA polymerase II promoter | 44/5968 | 77/18723 | 4.04e-06 | 5.05e-05 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa04919113 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491926 | Oral cavity | OSCC | Thyroid hormone signaling pathway | 73/3704 | 121/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 73 |
hsa04919112 | Oral cavity | OSCC | Thyroid hormone signaling pathway | 73/3704 | 121/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MED16 | SNV | Missense_Mutation | novel | c.1969N>A | p.Glu657Lys | p.E657K | Q9Y2X0 | protein_coding | deleterious(0) | possibly_damaging(0.82) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MED16 | deletion | Frame_Shift_Del | rs762481861 | c.1555_1556delNN | p.Gln519AlafsTer54 | p.Q519Afs*54 | Q9Y2X0 | protein_coding | TCGA-73-4676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | ||
MED16 | deletion | Frame_Shift_Del | novel | c.368delG | p.Gly123AlafsTer3 | p.G123Afs*3 | Q9Y2X0 | protein_coding | TCGA-78-7537-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MED16 | SNV | Missense_Mutation | novel | c.1085N>T | p.Ser362Leu | p.S362L | Q9Y2X0 | protein_coding | tolerated(0.36) | possibly_damaging(0.503) | TCGA-CQ-5333-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MED16 | SNV | Missense_Mutation | novel | c.2477N>G | p.Asn826Ser | p.N826S | Q9Y2X0 | protein_coding | tolerated(0.53) | benign(0.388) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MED16 | SNV | Missense_Mutation | rs748159188 | c.2409N>G | p.Cys803Trp | p.C803W | Q9Y2X0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CH-5746-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
MED16 | SNV | Missense_Mutation | c.1775N>C | p.Ile592Thr | p.I592T | Q9Y2X0 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MED16 | SNV | Missense_Mutation | rs780109775 | c.1535C>T | p.Thr512Met | p.T512M | Q9Y2X0 | protein_coding | tolerated(0.31) | benign(0.015) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MED16 | SNV | Missense_Mutation | c.1310C>T | p.Ser437Leu | p.S437L | Q9Y2X0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CG-4441-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MED16 | SNV | Missense_Mutation | c.1469N>C | p.Asp490Ala | p.D490A | Q9Y2X0 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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