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Gene: MCTP2 |
Gene summary for MCTP2 |
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Gene information | Species | Human | Gene symbol | MCTP2 | Gene ID | 55784 |
Gene name | multiple C2 and transmembrane domain containing 2 | |
Gene Alias | MCTP2 | |
Cytomap | 15q26.2 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q6DN12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55784 | MCTP2 | CA_HPV_1 | Human | Cervix | CC | 1.16e-02 | -7.50e-02 | 0.0264 |
55784 | MCTP2 | CCI_2 | Human | Cervix | CC | 4.72e-07 | 1.12e+00 | 0.5249 |
55784 | MCTP2 | CCI_3 | Human | Cervix | CC | 7.83e-04 | 4.99e-01 | 0.516 |
55784 | MCTP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.15e-30 | -8.01e-01 | 0.0155 |
55784 | MCTP2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.41e-06 | -9.18e-01 | 0.0216 |
55784 | MCTP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.46e-15 | 6.51e-01 | -0.1954 |
55784 | MCTP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.75e-02 | -4.59e-01 | -0.1207 |
55784 | MCTP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.33e-14 | -6.56e-01 | 0.096 |
55784 | MCTP2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.53e-05 | -9.15e-01 | 0.0451 |
55784 | MCTP2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.30e-06 | -6.93e-01 | 0.0528 |
55784 | MCTP2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.55e-11 | -6.15e-01 | 0.0338 |
55784 | MCTP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.03e-08 | -5.23e-01 | 0.0674 |
55784 | MCTP2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.15e-03 | -3.77e-01 | 0.0588 |
55784 | MCTP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.23e-06 | -3.81e-01 | 0.294 |
55784 | MCTP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.54e-43 | -8.92e-01 | 0.3859 |
55784 | MCTP2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.04e-05 | -7.59e-01 | 0.2585 |
55784 | MCTP2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.20e-55 | -1.01e+00 | 0.3005 |
55784 | MCTP2 | F007 | Human | Colorectum | FAP | 1.30e-03 | -4.12e-01 | 0.1176 |
55784 | MCTP2 | A001-C-207 | Human | Colorectum | FAP | 9.79e-08 | -4.97e-01 | 0.1278 |
55784 | MCTP2 | A015-C-203 | Human | Colorectum | FAP | 1.38e-48 | -9.17e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0023061 | Colorectum | FAP | signal release | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
GO:00230611 | Colorectum | CRC | signal release | 72/2078 | 463/18723 | 1.95e-03 | 1.96e-02 | 72 |
GO:0019932 | Lung | AIS | second-messenger-mediated signaling | 46/1849 | 312/18723 | 3.79e-03 | 3.52e-02 | 46 |
GO:00199321 | Lung | MIAC | second-messenger-mediated signaling | 30/967 | 312/18723 | 8.15e-04 | 1.80e-02 | 30 |
GO:0051588 | Lung | MIAC | regulation of neurotransmitter transport | 13/967 | 100/18723 | 1.89e-03 | 3.02e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
MCTP2 | MMC | Lung | Healthy | ID1,BCAS2,THBS1, etc. | 2.09e-03 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCTP2 | SNV | Missense_Mutation | novel | c.2011A>T | p.Ile671Leu | p.I671L | Q6DN12 | protein_coding | tolerated(0.66) | benign(0.015) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCTP2 | SNV | Missense_Mutation | c.1559N>G | p.Asp520Gly | p.D520G | Q6DN12 | protein_coding | tolerated(0.47) | probably_damaging(1) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MCTP2 | SNV | Missense_Mutation | c.2370N>A | p.Asn790Lys | p.N790K | Q6DN12 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MCTP2 | SNV | Missense_Mutation | rs764700909 | c.1120A>G | p.Thr374Ala | p.T374A | Q6DN12 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MCTP2 | SNV | Missense_Mutation | rs759600196 | c.1525G>A | p.Gly509Ser | p.G509S | Q6DN12 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MCTP2 | SNV | Missense_Mutation | novel | c.1372N>A | p.Leu458Met | p.L458M | Q6DN12 | protein_coding | tolerated(0.08) | benign(0.081) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
MCTP2 | SNV | Missense_Mutation | novel | c.1831N>T | p.Asp611Tyr | p.D611Y | Q6DN12 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
MCTP2 | SNV | Missense_Mutation | novel | c.1098N>T | p.Lys366Asn | p.K366N | Q6DN12 | protein_coding | deleterious(0.01) | benign(0.444) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCTP2 | SNV | Missense_Mutation | novel | c.1825A>C | p.Asn609His | p.N609H | Q6DN12 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-EY-A1GE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCTP2 | SNV | Missense_Mutation | novel | c.1580C>T | p.Ser527Leu | p.S527L | Q6DN12 | protein_coding | deleterious(0.03) | possibly_damaging(0.478) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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