|
Gene: MCOLN2 |
Gene summary for MCOLN2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MCOLN2 | Gene ID | 255231 |
Gene name | mucolipin TRP cation channel 2 | |
Gene Alias | TRP-ML2 | |
Cytomap | 1p22.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q8IZK6 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
255231 | MCOLN2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.51e-14 | -5.31e-01 | 0.0155 |
255231 | MCOLN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.49e-06 | -5.35e-01 | -0.0811 |
255231 | MCOLN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.24e-02 | -3.58e-01 | -0.1088 |
255231 | MCOLN2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.59e-12 | -4.99e-01 | -0.1001 |
255231 | MCOLN2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.29e-03 | -4.05e-01 | -0.059 |
255231 | MCOLN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.19e-13 | -5.35e-01 | 0.096 |
255231 | MCOLN2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.51e-04 | -3.74e-01 | 0.0674 |
255231 | MCOLN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.32e-02 | -3.00e-01 | 0.294 |
255231 | MCOLN2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.96e-05 | -5.23e-01 | 0.281 |
255231 | MCOLN2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.95e-12 | -4.79e-01 | 0.3859 |
255231 | MCOLN2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.72e-02 | -5.00e-01 | 0.2585 |
255231 | MCOLN2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.10e-08 | -4.65e-01 | 0.3005 |
255231 | MCOLN2 | F007 | Human | Colorectum | FAP | 1.81e-08 | -5.36e-01 | 0.1176 |
255231 | MCOLN2 | A002-C-010 | Human | Colorectum | FAP | 9.59e-05 | -2.87e-01 | 0.242 |
255231 | MCOLN2 | A001-C-207 | Human | Colorectum | FAP | 1.14e-02 | -3.30e-01 | 0.1278 |
255231 | MCOLN2 | A015-C-203 | Human | Colorectum | FAP | 3.22e-11 | -2.56e-01 | -0.1294 |
255231 | MCOLN2 | A015-C-204 | Human | Colorectum | FAP | 1.13e-03 | -3.39e-01 | -0.0228 |
255231 | MCOLN2 | A002-C-201 | Human | Colorectum | FAP | 1.06e-10 | -4.43e-01 | 0.0324 |
255231 | MCOLN2 | A002-C-203 | Human | Colorectum | FAP | 4.34e-04 | -2.67e-01 | 0.2786 |
255231 | MCOLN2 | A001-C-119 | Human | Colorectum | FAP | 4.07e-10 | -5.33e-01 | -0.1557 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072567 | Colorectum | AD | chemokine (C-X-C motif) ligand 2 production | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
GO:2000341 | Colorectum | AD | regulation of chemokine (C-X-C motif) ligand 2 production | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
GO:0051651 | Colorectum | AD | maintenance of location in cell | 61/3918 | 214/18723 | 5.02e-03 | 3.37e-02 | 61 |
GO:00725672 | Colorectum | MSS | chemokine (C-X-C motif) ligand 2 production | 10/3467 | 20/18723 | 1.40e-03 | 1.32e-02 | 10 |
GO:20003412 | Colorectum | MSS | regulation of chemokine (C-X-C motif) ligand 2 production | 10/3467 | 20/18723 | 1.40e-03 | 1.32e-02 | 10 |
GO:00516512 | Colorectum | MSS | maintenance of location in cell | 57/3467 | 214/18723 | 2.07e-03 | 1.76e-02 | 57 |
GO:2000343 | Colorectum | MSS | positive regulation of chemokine (C-X-C motif) ligand 2 production | 6/3467 | 11/18723 | 7.89e-03 | 4.84e-02 | 6 |
GO:00516513 | Colorectum | FAP | maintenance of location in cell | 46/2622 | 214/18723 | 1.76e-03 | 1.53e-02 | 46 |
GO:00725673 | Colorectum | FAP | chemokine (C-X-C motif) ligand 2 production | 8/2622 | 20/18723 | 3.83e-03 | 2.70e-02 | 8 |
GO:20003413 | Colorectum | FAP | regulation of chemokine (C-X-C motif) ligand 2 production | 8/2622 | 20/18723 | 3.83e-03 | 2.70e-02 | 8 |
GO:00516514 | Colorectum | CRC | maintenance of location in cell | 36/2078 | 214/18723 | 7.25e-03 | 4.98e-02 | 36 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCOLN2 | SNV | Missense_Mutation | novel | c.1613N>T | p.Glu538Val | p.E538V | Q8IZK6 | protein_coding | tolerated(0.09) | benign(0) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MCOLN2 | SNV | Missense_Mutation | novel | c.1114N>G | p.Leu372Val | p.L372V | Q8IZK6 | protein_coding | tolerated(0.09) | benign(0.133) | TCGA-CN-6011-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
MCOLN2 | SNV | Missense_Mutation | novel | c.1301N>A | p.Cys434Tyr | p.C434Y | Q8IZK6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CQ-6228-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MCOLN2 | SNV | Missense_Mutation | novel | c.532N>A | p.Glu178Lys | p.E178K | Q8IZK6 | protein_coding | tolerated(0.07) | benign(0.024) | TCGA-CQ-A4C9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
MCOLN2 | SNV | Missense_Mutation | rs200938463 | c.188N>T | p.Pro63Leu | p.P63L | Q8IZK6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
MCOLN2 | SNV | Missense_Mutation | c.352N>C | p.Ser118Arg | p.S118R | Q8IZK6 | protein_coding | tolerated(0.05) | possibly_damaging(0.855) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MCOLN2 | SNV | Missense_Mutation | c.82N>T | p.Ala28Ser | p.A28S | Q8IZK6 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-BR-8286-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MCOLN2 | SNV | Missense_Mutation | c.373N>C | p.Glu125Gln | p.E125Q | Q8IZK6 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-BR-8295-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MCOLN2 | SNV | Missense_Mutation | c.1143N>G | p.Phe381Leu | p.F381L | Q8IZK6 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MCOLN2 | SNV | Missense_Mutation | c.350N>G | p.Tyr117Cys | p.Y117C | Q8IZK6 | protein_coding | tolerated(0.07) | benign(0.071) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
255231 | MCOLN2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178100233 | ||
255231 | MCOLN2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178103002 | ||
255231 | MCOLN2 | ION CHANNEL, DRUGGABLE GENOME | activator | 381744982 |
Page: 1 |