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Gene: MCM9 |
Gene summary for MCM9 |
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Gene information | Species | Human | Gene symbol | MCM9 | Gene ID | 254394 |
Gene name | minichromosome maintenance 9 homologous recombination repair factor | |
Gene Alias | C6orf61 | |
Cytomap | 6q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NXL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254394 | MCM9 | CCI_1 | Human | Cervix | CC | 2.67e-04 | 5.28e-01 | 0.528 |
254394 | MCM9 | CCI_2 | Human | Cervix | CC | 2.95e-05 | 5.65e-01 | 0.5249 |
254394 | MCM9 | CCI_3 | Human | Cervix | CC | 9.75e-04 | 4.66e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00323923 | Cervix | CC | DNA geometric change | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCM9 | SNV | Missense_Mutation | c.19N>G | p.Thr7Ala | p.T7A | Q9NXL9 | protein_coding | tolerated(0.95) | benign(0.007) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MCM9 | SNV | Missense_Mutation | c.1016G>T | p.Gly339Val | p.G339V | Q9NXL9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MCM9 | SNV | Missense_Mutation | c.1015G>C | p.Gly339Arg | p.G339R | Q9NXL9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MCM9 | SNV | Missense_Mutation | c.625N>A | p.Gln209Lys | p.Q209K | Q9NXL9 | protein_coding | deleterious(0.02) | possibly_damaging(0.894) | TCGA-39-5022-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MCM9 | SNV | Missense_Mutation | c.1061N>G | p.Pro354Arg | p.P354R | Q9NXL9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-60-2709-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MCM9 | SNV | Missense_Mutation | c.269N>G | p.Val90Gly | p.V90G | Q9NXL9 | protein_coding | tolerated(0.07) | benign(0.145) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MCM9 | SNV | Missense_Mutation | novel | c.66N>C | p.Lys22Asn | p.K22N | Q9NXL9 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-BA-A8YP-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | CR |
MCM9 | SNV | Missense_Mutation | novel | c.472N>A | p.Ala158Thr | p.A158T | Q9NXL9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2A-A8W1-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
MCM9 | SNV | Missense_Mutation | novel | c.941N>G | p.Val314Gly | p.V314G | Q9NXL9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-HC-A6AL-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
MCM9 | SNV | Missense_Mutation | rs754275066 | c.176N>G | p.Asn59Ser | p.N59S | Q9NXL9 | protein_coding | tolerated(0.22) | possibly_damaging(0.898) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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