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Gene: MAP3K21 |
Gene summary for MAP3K21 |
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Gene information | Species | Human | Gene symbol | MAP3K21 | Gene ID | 84451 |
Gene name | mitogen-activated protein kinase kinase kinase 21 | |
Gene Alias | MLK4 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A1W2PKR9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84451 | MAP3K21 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.25e-10 | -4.98e-01 | 0.0155 |
84451 | MAP3K21 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.71e-05 | -4.54e-01 | -0.1808 |
84451 | MAP3K21 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.11e-03 | -4.70e-01 | -0.1207 |
84451 | MAP3K21 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.24e-06 | -3.32e-01 | -0.1464 |
84451 | MAP3K21 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.08e-08 | -3.53e-01 | -0.1001 |
84451 | MAP3K21 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.16e-09 | -4.97e-01 | 0.096 |
84451 | MAP3K21 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.49e-03 | -3.04e-01 | 0.0674 |
84451 | MAP3K21 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.09e-36 | -6.16e-01 | 0.294 |
84451 | MAP3K21 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.47e-12 | -6.16e-01 | 0.281 |
84451 | MAP3K21 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.14e-33 | -6.16e-01 | 0.3859 |
84451 | MAP3K21 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.25e-09 | -6.16e-01 | 0.2585 |
84451 | MAP3K21 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.96e-35 | -6.16e-01 | 0.3005 |
84451 | MAP3K21 | A001-C-207 | Human | Colorectum | FAP | 1.26e-06 | -4.10e-01 | 0.1278 |
84451 | MAP3K21 | A015-C-203 | Human | Colorectum | FAP | 1.33e-25 | -4.77e-01 | -0.1294 |
84451 | MAP3K21 | A015-C-204 | Human | Colorectum | FAP | 1.94e-06 | -3.78e-01 | -0.0228 |
84451 | MAP3K21 | A014-C-040 | Human | Colorectum | FAP | 7.52e-03 | -3.77e-01 | -0.1184 |
84451 | MAP3K21 | A002-C-201 | Human | Colorectum | FAP | 1.70e-15 | -4.61e-01 | 0.0324 |
84451 | MAP3K21 | A002-C-203 | Human | Colorectum | FAP | 1.85e-04 | -2.53e-01 | 0.2786 |
84451 | MAP3K21 | A001-C-119 | Human | Colorectum | FAP | 7.63e-08 | -4.22e-01 | -0.1557 |
84451 | MAP3K21 | A001-C-108 | Human | Colorectum | FAP | 7.48e-17 | -3.58e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:00467771 | Colorectum | SER | protein autophosphorylation | 60/2897 | 227/18723 | 1.36e-05 | 4.25e-04 | 60 |
GO:00467772 | Colorectum | MSS | protein autophosphorylation | 63/3467 | 227/18723 | 3.96e-04 | 4.91e-03 | 63 |
GO:00467773 | Colorectum | FAP | protein autophosphorylation | 52/2622 | 227/18723 | 1.88e-04 | 2.76e-03 | 52 |
GO:00467774 | Colorectum | CRC | protein autophosphorylation | 42/2078 | 227/18723 | 6.08e-04 | 8.10e-03 | 42 |
GO:00467775 | Liver | HCC | protein autophosphorylation | 123/7958 | 227/18723 | 2.40e-04 | 1.80e-03 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04010 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa040101 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa040102 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa040103 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP3K21 | SNV | Missense_Mutation | rs550700262 | c.1186N>A | p.Glu396Lys | p.E396K | Q5TCX8 | protein_coding | tolerated(0.4) | benign(0.022) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K21 | SNV | Missense_Mutation | c.1052N>T | p.Ala351Val | p.A351V | Q5TCX8 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP3K21 | SNV | Missense_Mutation | c.865N>T | p.Asp289Tyr | p.D289Y | Q5TCX8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MAP3K21 | SNV | Missense_Mutation | c.1510N>T | p.Arg504Cys | p.R504C | Q5TCX8 | protein_coding | deleterious(0.02) | possibly_damaging(0.616) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MAP3K21 | SNV | Missense_Mutation | c.2083G>A | p.Ala695Thr | p.A695T | Q5TCX8 | protein_coding | tolerated(0.48) | benign(0.015) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP3K21 | SNV | Missense_Mutation | rs779367692 | c.940N>A | p.Glu314Lys | p.E314K | Q5TCX8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAP3K21 | SNV | Missense_Mutation | rs748650251 | c.1604N>A | p.Arg535Gln | p.R535Q | Q5TCX8 | protein_coding | deleterious(0) | benign(0.069) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP3K21 | SNV | Missense_Mutation | rs770498631 | c.1051G>A | p.Ala351Thr | p.A351T | Q5TCX8 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MAP3K21 | SNV | Missense_Mutation | c.1409G>A | p.Arg470His | p.R470H | Q5TCX8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
MAP3K21 | SNV | Missense_Mutation | novel | c.1578G>T | p.Gln526His | p.Q526H | Q5TCX8 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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