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Gene: MANEA |
Gene summary for MANEA |
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Gene information | Species | Human | Gene symbol | MANEA | Gene ID | 79694 |
Gene name | mannosidase endo-alpha | |
Gene Alias | ENDO | |
Cytomap | 6q16.1 | |
Gene Type | protein-coding | GO ID | GO:0000139 | UniProtAcc | Q5SRI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79694 | MANEA | HCC1_Meng | Human | Liver | HCC | 2.81e-47 | 1.25e-01 | 0.0246 |
79694 | MANEA | HCC2_Meng | Human | Liver | HCC | 9.16e-11 | 1.11e-01 | 0.0107 |
79694 | MANEA | HCC1 | Human | Liver | HCC | 2.77e-06 | 2.78e+00 | 0.5336 |
79694 | MANEA | HCC2 | Human | Liver | HCC | 2.29e-06 | 2.01e+00 | 0.5341 |
79694 | MANEA | S014 | Human | Liver | HCC | 2.91e-15 | 4.84e-01 | 0.2254 |
79694 | MANEA | S015 | Human | Liver | HCC | 6.29e-14 | 6.27e-01 | 0.2375 |
79694 | MANEA | S016 | Human | Liver | HCC | 6.57e-27 | 7.00e-01 | 0.2243 |
79694 | MANEA | S027 | Human | Liver | HCC | 7.08e-05 | 5.27e-01 | 0.2446 |
79694 | MANEA | S028 | Human | Liver | HCC | 1.98e-14 | 4.66e-01 | 0.2503 |
79694 | MANEA | S029 | Human | Liver | HCC | 1.72e-14 | 5.16e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MANEA | SNV | Missense_Mutation | rs776851480 | c.1178N>T | p.Arg393Leu | p.R393L | Q5SRI9 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MANEA | SNV | Missense_Mutation | c.1340N>T | p.Ser447Ile | p.S447I | Q5SRI9 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MANEA | SNV | Missense_Mutation | c.484N>T | p.Ser162Cys | p.S162C | Q5SRI9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-L9-A743-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxotere | CR | |
MANEA | SNV | Missense_Mutation | c.952N>C | p.Asp318His | p.D318H | Q5SRI9 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-18-5595-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MANEA | SNV | Missense_Mutation | c.952N>T | p.Asp318Tyr | p.D318Y | Q5SRI9 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-33-4583-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MANEA | SNV | Missense_Mutation | rs771974396 | c.64N>G | p.Leu22Val | p.L22V | Q5SRI9 | protein_coding | tolerated(0.83) | benign(0.005) | TCGA-33-4587-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | etoposide | PD |
MANEA | SNV | Missense_Mutation | c.1243N>C | p.Val415Leu | p.V415L | Q5SRI9 | protein_coding | deleterious(0.01) | benign(0.065) | TCGA-34-5927-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
MANEA | SNV | Missense_Mutation | novel | c.1328N>G | p.Ser443Cys | p.S443C | Q5SRI9 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-34-7107-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MANEA | SNV | Missense_Mutation | novel | c.814N>T | p.Ile272Phe | p.I272F | Q5SRI9 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-37-A5EM-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MANEA | SNV | Missense_Mutation | c.1165G>C | p.Ala389Pro | p.A389P | Q5SRI9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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