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Gene: MAGEB10 |
Gene summary for MAGEB10 |
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Gene information | Species | Human | Gene symbol | MAGEB10 | Gene ID | 139422 |
Gene name | MAGE family member B10 | |
Gene Alias | MAGEB10 | |
Cytomap | Xp21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96LZ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
139422 | MAGEB10 | HCC1 | Human | Liver | HCC | 7.19e-14 | 9.30e-01 | 0.5336 |
139422 | MAGEB10 | HCC2 | Human | Liver | HCC | 1.12e-12 | 6.89e-01 | 0.5341 |
139422 | MAGEB10 | HCC5 | Human | Liver | HCC | 1.75e-08 | 8.45e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEB10 | SNV | Missense_Mutation | c.782N>T | p.Gln261Leu | p.Q261L | Q96LZ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.83) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | novel | c.56G>T | p.Arg19Leu | p.R19L | Q96LZ2 | protein_coding | deleterious(0) | benign(0.41) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | c.437N>T | p.Lys146Met | p.K146M | Q96LZ2 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
MAGEB10 | SNV | Missense_Mutation | novel | c.455N>C | p.Ile152Thr | p.I152T | Q96LZ2 | protein_coding | deleterious(0.01) | possibly_damaging(0.495) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | novel | c.202C>A | p.Gln68Lys | p.Q68K | Q96LZ2 | protein_coding | tolerated(0.47) | benign(0.053) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGEB10 | SNV | Missense_Mutation | c.68N>T | p.Glu23Val | p.E23V | Q96LZ2 | protein_coding | deleterious(0.01) | benign(0.125) | TCGA-S2-AA1A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | novel | c.625G>T | p.Gly209Cys | p.G209C | Q96LZ2 | protein_coding | tolerated(0.16) | possibly_damaging(0.896) | TCGA-33-AASB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAGEB10 | SNV | Missense_Mutation | novel | c.85C>G | p.Leu29Val | p.L29V | Q96LZ2 | protein_coding | deleterious(0.02) | benign(0.375) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MAGEB10 | SNV | Missense_Mutation | c.554A>G | p.Asp185Gly | p.D185G | Q96LZ2 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-66-2786-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEB10 | SNV | Missense_Mutation | c.684C>A | p.Asn228Lys | p.N228K | Q96LZ2 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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