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Gene: MAGEA11 |
Gene summary for MAGEA11 |
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Gene information | Species | Human | Gene symbol | MAGEA11 | Gene ID | 4110 |
Gene name | MAGE family member A11 | |
Gene Alias | CT1.11 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | G5E962 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4110 | MAGEA11 | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 4.66e-01 | 0.082 |
4110 | MAGEA11 | LZE4T | Human | Esophagus | ESCC | 3.78e-08 | 2.52e-01 | 0.0811 |
4110 | MAGEA11 | LZE24T | Human | Esophagus | ESCC | 6.88e-12 | 3.04e-01 | 0.0596 |
4110 | MAGEA11 | P2T-E | Human | Esophagus | ESCC | 3.96e-39 | 6.22e-01 | 0.1177 |
4110 | MAGEA11 | P4T-E | Human | Esophagus | ESCC | 3.18e-14 | 2.92e-01 | 0.1323 |
4110 | MAGEA11 | P5T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.67e-01 | 0.1327 |
4110 | MAGEA11 | P9T-E | Human | Esophagus | ESCC | 1.08e-07 | 2.28e-01 | 0.1131 |
4110 | MAGEA11 | P10T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.35e-01 | 0.116 |
4110 | MAGEA11 | P15T-E | Human | Esophagus | ESCC | 1.87e-22 | 4.44e-01 | 0.1149 |
4110 | MAGEA11 | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.22e-01 | 0.1278 |
4110 | MAGEA11 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 5.72e-01 | 0.1662 |
4110 | MAGEA11 | P20T-E | Human | Esophagus | ESCC | 1.17e-04 | 1.40e-01 | 0.1124 |
4110 | MAGEA11 | P26T-E | Human | Esophagus | ESCC | 5.22e-43 | 7.46e-01 | 0.1276 |
4110 | MAGEA11 | P28T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.71e-01 | 0.1149 |
4110 | MAGEA11 | P37T-E | Human | Esophagus | ESCC | 2.70e-23 | 4.66e-01 | 0.1371 |
4110 | MAGEA11 | P42T-E | Human | Esophagus | ESCC | 6.59e-08 | 2.26e-01 | 0.1175 |
4110 | MAGEA11 | P47T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.00e-01 | 0.1067 |
4110 | MAGEA11 | P54T-E | Human | Esophagus | ESCC | 9.07e-08 | 2.04e-01 | 0.0975 |
4110 | MAGEA11 | P56T-E | Human | Esophagus | ESCC | 1.26e-12 | 1.13e+00 | 0.1613 |
4110 | MAGEA11 | P57T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.15e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEA11 | SNV | Missense_Mutation | novel | c.816N>T | p.Gln272His | p.Q272H | P43364 | protein_coding | deleterious(0.04) | benign(0.246) | TCGA-34-5928-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGEA11 | SNV | Missense_Mutation | novel | c.778N>C | p.Phe260Leu | p.F260L | P43364 | protein_coding | deleterious(0.03) | probably_damaging(0.947) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAGEA11 | SNV | Missense_Mutation | c.704G>T | p.Arg235Leu | p.R235L | P43364 | protein_coding | tolerated(0.66) | benign(0.001) | TCGA-37-4135-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAGEA11 | SNV | Missense_Mutation | novel | c.23N>T | p.Gly8Val | p.G8V | P43364 | protein_coding | tolerated_low_confidence(0.19) | benign(0.053) | TCGA-43-8115-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
MAGEA11 | SNV | Missense_Mutation | novel | c.989N>A | p.Pro330His | p.P330H | P43364 | protein_coding | deleterious(0.01) | possibly_damaging(0.566) | TCGA-56-8201-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAGEA11 | SNV | Missense_Mutation | novel | c.1191N>A | p.Met397Ile | p.M397I | P43364 | protein_coding | deleterious(0.04) | benign(0.345) | TCGA-58-8393-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGEA11 | SNV | Missense_Mutation | c.208G>T | p.Ala70Ser | p.A70S | P43364 | protein_coding | tolerated_low_confidence(0.11) | benign(0.291) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MAGEA11 | SNV | Missense_Mutation | c.357C>A | p.His119Gln | p.H119Q | P43364 | protein_coding | tolerated(0.32) | probably_damaging(0.932) | TCGA-66-2788-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGEA11 | SNV | Missense_Mutation | novel | c.1119N>T | p.Gln373His | p.Q373H | P43364 | protein_coding | deleterious(0) | possibly_damaging(0.628) | TCGA-68-7755-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unspecific | SD | |
MAGEA11 | SNV | Missense_Mutation | c.126C>G | p.Phe42Leu | p.F42L | P43364 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-77-7337-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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